High-sensitivity C-reactive protein and exercise-induced changes in subjects suspected of coronary artery disease

Mouridsen, Mette Rauhe; Nielsen, Olav Wendelboe; Carlsen, Christian Malchau; Mattsson, Nick; Ruwald, Martin H.; Binici, Zeynep; Sajadieh, Ahmad

doi:10.2147/jir.s54360

Cited by 12 publications

(13 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this direction, different epidemiologic studies have revealed that specific SNPs in the different genes such as IL-6, 13 , 16 – 18 IL-17, 19 IL-18, 20 and IL-23 are associated with the development of CAD. 21 – 27 In the present study, a significant association between the CAD GG carriers of rs1946518 and rs187238 SNPs and the higher circulating IL-8 levels was shown. In contrast, their respective heterozygote carriers (TG and GC) showed a significant association with lower IL-6 and IL-8 levels.…”

Section: Discussionsupporting

confidence: 60%

Association between IL-18/18R gene polymorphisms and coronary artery disease: influence of IL-18/18R genetic variants on cytokine expression

Mitrokhin

Nikitin

Brovkina

et al. 2018

JIR

View full text Add to dashboard Cite

PurposeThe present study investigated the influence of IL-18/18R genetic variants on cytokine expression in patients with stable coronary artery disease (CAD).Materials and methodsThe polymorphisms rs1946518, rs187238, rs326, rs1169288, and rs183130 were determined in patients with and without CAD. Circulating cytokine levels were measured immunologically.ResultsThe rs1946518-GG genotype shows higher IL-18 concentration in the group with CAD, but still not significant. The TG genotype from rs1946518 in carriers with CAD showed a significant decrease in relation to the pro-inflammatory cytokines IL-6, IL-8, and IL-18. The decreases of IL-6 and IL-8 were also specific for rs187238 CAD carriers with the GC genotype. The CAD carriers with the AA genotype from rs326 in the IL-18R gene showed significant increase in IL-8 and IL-18 in comparison with those without CAD. Regarding rs1169288 from the IL-18R gene, IL-8 showed a T allele-dependent increase. In the last rs183130 polymorphism of the IL-18R gene, the pro-inflammatory onset showed a C allele-dependent disease-associated decrease in IL-8 CC and IL-6 CT carriers. In contrast, the CAD CT carriers in relation to IL-8 showed significant increase.ConclusionsMost of the IL-18/18R single-nucleotide polymorphisms were mainly associated with pro-inflammatory cytokines. It is surmised that these associations between some pro-inflammatory cytokines (mainly IL-8) and some IL-18R genotypes in the subjects with CAD from this study are most likely based on inflammatory-induced upregulation of IL-18R expression.

show abstract

Section: Discussionsupporting

confidence: 60%

Association between IL-18/18R gene polymorphisms and coronary artery disease: influence of IL-18/18R genetic variants on cytokine expression

Mitrokhin

Nikitin

Brovkina

et al. 2018

JIR

View full text Add to dashboard Cite

show abstract

“…Evidence exists showing exercise increases hsCRP up to 24-h post exercise, but this is in individuals who have performed very strenuous physical activities such as running marathons. 87 In a cohort of patients with coronary artery disease, Mouridsen et al 39 found that hsCRP increased in the first 5 min following a moderate exercise test, but that this increase was attenuated at 20-h. 39 These results indicate that exercise could cause unwanted variation in post intervention hsCRP levels.…”

Section: Discussionmentioning

confidence: 99%

“…37 Finally, baseline hsCRP may be elevated in patients who have recently experienced a cardiac event, 38 and post exercise levels of hsCRP may be elevated in the period directly following intense exercise. 39 …”

Section: Introductionmentioning

confidence: 99%

Effects of exercise on c-reactive protein in healthy patients and in patients with heart disease: A meta-analysis

et al. 2016

View full text Add to dashboard Cite

Decreases in circulating hsCRP have been associated with increased physical activity and exercise training, although the ability of exercise interventions to reduce hsCRP and which individuals benefit the most remains unclear. This meta-analysis evaluates the ability of exercise to reduce hsCRP levels in healthy individuals and in individuals with heart disease. A systematic review and meta-analysis was conducted that included exercise interventions trials from 1995 to 2012. Forty-three studies were included in the final analysis for a total of 3575 participants. Exercise interventions significantly reduced hsCRP (standardized mean difference −0.53 mg/L; 95% CI, −0.74 to −0.33). Results of sub-analysis revealed no significant difference in reductions in hsCRP between healthy adults and those with heart disease (p = .20). Heterogeneity between studies could not be attributed to age, gender, intervention length, intervention type, or inclusion of diet modification. Exercise interventions reduced hsCRP levels in adults irrespective of the presence of heart disease.

show abstract

“…Study in subjects suspected of coronary artery disease, a symptom-limited exercise stress test induced increase in CRP significantly. The results indicate that the exercise has potential to cause unwanted variations of CRP (Mouridsen et al 2014).…”

Section: Discussionmentioning

confidence: 92%

The Effects of Physical Exercises on C-Reactive Protein in Patients With Post Ischemic Stroke

Laswati¹,

Andriana²,

Subadi³

et al. 2017

FMI

View full text Add to dashboard Cite

Several studies have recently highlighted the important role of physical exercise in regulation inflammatory status, but there is relatively little known about markers of inflammation levels after physical exercise in post ischemic stroke patients. The aims of this study to provide the effects of physical exercise using Partial Body-Weight Supported Treadmill Training –Audio Cues (PBWSTT-AC) and Traditional method on the level of inflammatory markers C-Reactive Protein (CRP). This study using pretest-postest control group design, 14 post ischemic stroke patients were randomized and allocate to two groups: Group1 (control group) received traditional walking exercise and group 2 received PBWSTT-AC. The walking exercise study were conducted for 20 minute 3 times a week for 12 sessions (4 weeks). Before and after 12 session of exercises, the serum levels of CRP were determined using immunoserology. All statistical test were carried out using SPSS 17 and statistical significance was set at p<0.05 for all analysis. The CRP levels between group were compared using Student t test or Mann-Whitney test. From multiple comparisons statistic result, no significant difference between groups (p=0.898), that seem in this study the levels of CRP of poststroke patients is not influenced by the Traditional training and PBWSTT-AC. The conclusion of this study that both traditional method and PBWTT-AC in 4 weeks exercise training seem have no effect on CRP levels.

show abstract

High-sensitivity C-reactive protein and exercise-induced changes in subjects suspected of coronary artery disease

Cited by 12 publications

References 38 publications

Association between IL-18/18R gene polymorphisms and coronary artery disease: influence of IL-18/18R genetic variants on cytokine expression

Association between IL-18/18R gene polymorphisms and coronary artery disease: influence of IL-18/18R genetic variants on cytokine expression

Effects of exercise on c-reactive protein in healthy patients and in patients with heart disease: A meta-analysis

The Effects of Physical Exercises on C-Reactive Protein in Patients With Post Ischemic Stroke

Contact Info

Product

Resources

About