High-sensitivity C-reactive protein and cardiovascular risk in patients with coronary heart disease

Rosenson, Robert S.; Köenig, Wolfgang

doi:10.1097/00001573-200207000-00001

Cited by 48 publications

(30 citation statements)

References 67 publications

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“…Therefore, the hs-CRP concentration is a very useful nonspecific biochemical marker of inflammation, the measurement of which makes an important contribution to screening organ disease and monitoring the response to treatment of inflammation and infection [3]. Furthermore, many previous reports have suggested that high concentrations of hs-CRP are associated with an increased risk of cardiovascular disease, stroke and cognitive impairment, including dementia [2, 4, 5, 9,26,27,28,29]. …”

Section: Discussionmentioning

confidence: 99%

“…hs-CRP and fibrinogen are the most frequently studied biomarkers [6, 7]. Therefore, hs-CRP levels have attracted clinical attention as predictive markers of atherosclerosis, and recent studies have shown that elevated hs-CRP values independently predict the risk of future cardiovascular diseases and ischemic cerebrovascular diseases (iCVDs), including transient ischemic attack in the elderly [1, 8, 9]. …”

Section: Introductionmentioning

confidence: 99%

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Is There an Association between the Level of High-Sensitivity C-Reactive Protein and Idiopathic Parkinson’s Disease? A Comparison of Parkinson’s Disease Patients, Disease Controls and Healthy Individuals

et al. 2009

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Background: High-sensitivity C-reactive protein (hs-CRP) is a sensitive systemic marker of inflammation, and increased levels of hs-CRP are associated with inflammatory reactions. Microglia-mediated neuroinflammation has been hypothesized to play an important role in the pathogenesis of idiopathic Parkinson’s disease (PD). However, the clinical value of hs-CRP in PD is poorly defined. Therefore, we conducted this study to investigate the clinical value of hs-CRP in patients with PD. Methods: We examined 212 patients with de novo PD, 253 patients with acute ischemic cerebrovascular disease and 119 healthy subjects and investigated the differences in hs-CRP among these 3 groups. The PD group was classified into 4 subgroups according to the Hoehn and Yahr stage to investigate the relationship between hs-CRP and symptom severity. Results: There was no significant difference in the hs-CRP value between the PD and the ischemic cerebrovascular disease groups, but the subjects in the 2 disease groups demonstrated higher hs-CRP levels than those in the normal control group. A post-hoc analysis of the 4 PD subgroups showed no significant differences in hs-CRP values. In addition, this study demonstrated that the odds ratio of the PD group by hs-CRP was 2.037 (95% CI 1.180–3.517; p = 0.011). Conclusion: We suggest that our results could support the hypothesis that neuroinflammation contributed to the pathogenesis of PD and cautiously assume that elevated hs-CRP might have a clinical value as a risk factor for PD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Is There an Association between the Level of High-Sensitivity C-Reactive Protein and Idiopathic Parkinson’s Disease? A Comparison of Parkinson’s Disease Patients, Disease Controls and Healthy Individuals

et al. 2009

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“…Accordingly, these two biomarkers have attracted clinical attention as potential predictive markers of atherosclerosis. Furthermore, many previous reports have suggested that high concentrations of hs-CRP and fibrinogen are associated with an increased risk of cardiovascular disease, stroke and cognitive impairment, including dementia (1,6,10,12,13). Therefore, in this study, we compared the levels of hs-CRP and fibrinogen, the most studied biomarkers of systemic inflammation, between PD patients with dementia (PDD) and PD patients without dementia (PDwoD), as well as normal control group subjects, to clearly evaluate the effects of inflammation on the occurrence of dementia in PD patients.…”

Section: Is Neuroinflammation Involved In the Development Of Dementiamentioning

confidence: 99%

Is Neuroinflammation Involved in the Development of Dementia in Patients with Parkinson's Disease?

et al. 2013

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Objective High-sensitivity C-reactive protein (hs-CRP) is an extremely sensitive systemic marker of inflammation and tissue damage, and increased levels of hs-CRP are strongly associated with inflammatory reactions. Microglia-mediated neuroinflammation has been hypothesized to play an important role in the pathogenesis of idiopathic Parkinson's disease (PD). However, the clinical value of the hs-CRP level in patients with PD is poorly defined. Therefore, we conducted this study to analyze the differences in the hs-CRP levels in PD patients with and without dementia. Methods We examined 72 PD patients without dementia (PDwoD) and 45 PD patients with dementia (PDD), as well as 84 control subjects. We investigated the differences in the hs-CRP and fibrinogen levels between these three groups. Results The mean hs-CRP and fibrinogen values were not significantly different between the PDwoD and PDD groups; however, these two groups had significantly higher mean hs-CRP and fibrinogen values than the control group. Conclusion It is known that inflammation plays a role in the pathogenesis of PD and dementia. However, based on the results of this study, we cautiously speculate that although neuroinflammation plays a role in the development of neurodegenerative diseases, including PD and dementia, it may be unrelated to the pathogenesis of dementia in patients with PD.

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“…Substantial evidence linking CRP concentrations and subsequent CVD risk in the general population now exists (16). Most of the studies that show such a link (17,18) have utilized high-sensitivity CRP assays, which estimate the value of CRP within what is considered to be the normal range.…”

mentioning

confidence: 99%

Baseline levels of c‐reactive protein and prediction of death from cardiovascular disease in patients with inflammatory polyarthritis : A ten‐year followup study of a primary care–based inception cohort

Goodson

Symmons

Scott

et al. 2005

Arthritis & Rheumatism

262

141

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Objective. To test the hypothesis that the C-reactive protein (CRP) concentration at baseline is an independent predictor of death from cardiovascular disease (CVD) in newly diagnosed patients with inflammatory polyarthritis (IP).Methods. Patients with IP (n ‫؍‬ 506) who were recruited from the Norfolk Arthritis Register between 1990 and 1992 were followed up to the end of 2001, and complete data on mortality were obtained. At baseline, subjects underwent a structured interview and joint examination and completed a Health Assessment Questionnaire (HAQ). Blood was obtained and analyzed for rheumatoid factor (RF) and CRP concentration. Cox regression was used to calculate hazards ratios (HRs) for risk of death from CVD.Results. The median followup was 10.1 years (interquartile range 9.3-10.8). There were 104 deaths, 40 of which were the result of CVD. Elevated CRP levels (>5 mg/liter) predicted death from CVD in univariate analyses: HR 3.9 (95% confidence interval [95% CI] 1.2-13.4) for men, and HR 4.22 (95% CI 1.4-12.6) for women. After adjusting for age and sex, the CVD mortality association was strongest in the subgroup of patients who were RF positive at baseline (adjusted HR 7.4 [95% CI 1.7-32.2]). Multivariate analysis revealed that elevated CRP levels remained a significant independent predictor of death from CVD, even after adjusting for age, sex, smoking status, HAQ score, RF positivity, and swollen joint counts (HR 3.3 [95% CI 1.4-7.6]).Conclusion. The CRP concentration at baseline is an important predictor of subsequent death from CVD in patients with new-onset IP and is independent of other indicators of disease severity. This supports the theory that CRP may play a direct role in the pathogenesis of CVD.

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High-sensitivity C-reactive protein and cardiovascular risk in patients with coronary heart disease

Cited by 48 publications

References 67 publications

Is There an Association between the Level of High-Sensitivity C-Reactive Protein and Idiopathic Parkinson’s Disease? A Comparison of Parkinson’s Disease Patients, Disease Controls and Healthy Individuals

Is There an Association between the Level of High-Sensitivity C-Reactive Protein and Idiopathic Parkinson’s Disease? A Comparison of Parkinson’s Disease Patients, Disease Controls and Healthy Individuals

Is Neuroinflammation Involved in the Development of Dementia in Patients with Parkinson's Disease?

Baseline levels of c‐reactive protein and prediction of death from cardiovascular disease in patients with inflammatory polyarthritis : A ten‐year followup study of a primary care–based inception cohort

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