High sensitive and selective C-reactive protein detection by means of lossy mode resonance based optical fiber devices

Zubiate, Pablo; Zamarreño, Carlos R.; Sanchez, Pedro; Matı́as, Ignacio R.; Arregui, Francisco J.

doi:10.1016/j.bios.2016.09.020

Cited by 101 publications

(56 citation statements)

References 27 publications

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“…The comparison between our method and other reported biosensors for the detection of CRP Â 10 À7 ng mL À1 21 fg mL À1 to 6.148 pg mLÀ1 18 Â 10 À8 ng mL À1 1 15. ag mL À1 to 115 mg mL À1 17 Magnetoimpedance-based biosensor 1.0 Â 10 À3 ng mL À1 1 pg mL À1 to 100 ng mL À1 Open Access Article.…”

mentioning

confidence: 88%

“…As presented in Table 1, CRP detection performance of our strategy was comparable to the reported in most of the other studies. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]…”

Section: Sensitivity For Crp Detectionmentioning

confidence: 99%

“…2 The most widely used CRP diagnostic methods are antibody-based assays. 2 At present, several techniques including the use of a capacitive biosensor, 3 microuidic biosensor, 4-6 electrochemical biosensor, [7][8][9] sandwich immunoassay, 10,11 uorescent biosensor, 12 chemiluminescence immunoassay, 13 micro-uxgate sensor, 14 ber optic biosensor, 15 magnetoimpedancebased biosensor, 16 nanowire-mesh biosensor 17 and electrochemical impedance spectroscopy 18 have been developed for the detection of CRP. However, these methods for CRP detection are usually time-consuming, labor-intensive, complex in operation or preparation and involve expensive reagents.…”

Section: Introductionmentioning

confidence: 99%

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Ultrasensitive fluorescent aptasensor for CRP detection based on the RNase H assisted DNA recycling signal amplification strategy

et al. 2019

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mentioning

confidence: 88%

“…As presented in Table 1, CRP detection performance of our strategy was comparable to the reported in most of the other studies. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]…”

Section: Sensitivity For Crp Detectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ultrasensitive fluorescent aptasensor for CRP detection based on the RNase H assisted DNA recycling signal amplification strategy

et al. 2019

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“…Over the last few decades, high-κ dielectric metal oxide thin film-coated optical sensors have been a high-interest topic. The development of biomaterials, adsorption, immobilization, and fabrication methods on the surface brought new vitality into this field [18][19][20][21]. According to the previous literature, metal oxide thin-film overlays fabricated onto the core of optical fibers can produce selective optical-power absorption at certain wavelengths, also known as resonances [22,23].…”

Section: Introductionmentioning

confidence: 99%

“…Compared with prism-based LMR sensors, optical fiber-based LMR sensors are less costly, more portable, and more convenient to use; moreover, that provides online remote detection of refractive-index variations of the bulk medium due to the implemented optical-fiber network. So, in recent decades, a great number of works about LMR sensors based on optical fibers have been published [19,26,[30][31][32][33][34][35][36][37]. However, optical fiber-based LMR sensors are frangible and not easy to handle during cleaning procedures, coating processes, and surface modification for special target detection.…”

Section: Introductionmentioning

confidence: 99%

Lossy Mode Resonance-Based Glucose Sensor with High-κ Dielectric Film

2019

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In the past, high-κ dielectrics gained much attention because of the constant demand for increasingly smaller semiconductors. At the same time, in the field of optical sensing, high-κ dielectrics are key materials. This study presents the experimental investigations on a lossy mode resonance-based optical planar waveguide (LMROPW) sensor coated with a high-κdielectric of an indium tin oxide (ITO) layer. Two types of sensing structures were fabricated by coating (i) only a single-layer ITO (or bared LMROPW) and (ii) an ITO layer with glucose probes onto the optical planar waveguide (or boronic LMROPW) to detect glucose molecules. The sensing characteristics of these two types of sensors toward the surrounding analyte were determined using different concentrations of glucose solutions. It was found that the bared LMROPW sensor is only suitable for a higher concentration of glucose; the boronic LMROPW sensor with glucose probes on ITO could be applied to a lower-concentration solution to monitor glucose adsorption onto the sensing surface. Furthermore, with the advantages of a simple structure, easy alignment, and suitable production, the LMROPW sensor with a high-κ dielectric surface could be applied in clinical testing and diagnostics.

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Advances in Fiber‐Optic Technology for Point‐of‐Care Diagnosis and In Vivo Biosensing

Tabassum

Kumar

2020

Adv Materials Technologies

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Development of reliable, sensitive, selective, and miniaturized sensing technologies is critical for health assessment and early diagnosis and treatment of diseases/anomalies while simultaneously mitigating the challenges associated with in vivo measurements. Some critical constraints to the realization of in vivo measurements include the necessity to fabricate the sensor on a tightly constrained footprint while ensuring acceptable biocompatibility, accuracy, and reliability. The inherent light-guiding properties of optical fibers over long distances, their microscopic cross-section that can be structured at the nanoscale to manipulate the light transmittance/reflectance spectrum, excellent biocompatibility enabling their efficient integration with bio-recognition molecules, immunity to electromagnetic interference, mechanical flexibility, and low cost have been inviting research attention to utilize these unique features for in vivo and label-free point-ofcare diagnostics. Hence, fiber-optic biosensing has become a promising research thrust, with a plethora of emerging methodologies to develop ultrasensitive and selective sensing probes.A unified presentation of the research trends on biosensors incorporated into optical fibers is presented.

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High sensitive and selective C-reactive protein detection by means of lossy mode resonance based optical fiber devices

Cited by 101 publications

References 27 publications

Ultrasensitive fluorescent aptasensor for CRP detection based on the RNase H assisted DNA recycling signal amplification strategy

Ultrasensitive fluorescent aptasensor for CRP detection based on the RNase H assisted DNA recycling signal amplification strategy

Lossy Mode Resonance-Based Glucose Sensor with High-κ Dielectric Film

Advances in Fiber‐Optic Technology for Point‐of‐Care Diagnosis and In Vivo Biosensing

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