High Sclerostin and Dickkopf-1 (DKK-1) Serum Levels in Children and Adolescents With Type 1 Diabetes Mellitus

Faienza, Maria Felicia; Ventura, Alessandro; Delvecchio, Maurizio; Fusillo, Anna; Piacente, Laura; Aceto, Gabriella; Colaianni, Graziana; Colucci, Silvia; Cavallo, Luciano; Grano, Maria; Brunetti, Giacomina

doi:10.1210/jc.2016-2371

Cited by 74 publications

(62 citation statements)

References 33 publications

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“…Although the biological roles of sclerostin and corresponding benefits of antisclerostin antibodies have been illuminated, much epidemiological data regarding serum sclerostin levels is still unclear. Most researches about sclerostin levels are focused on special groups, and there are few studies on general healthy people from communities (He et al, 2014;Faienza et al, 2017;Hansen et al, 2019;Pekkolay et al, 2019;Singh et al, 2019;Yang et al, 2019). The associations of serum sclerostin to bone metabolism markers in different population show inconsistent results, and only a few studies have been conducted to investigate relations of serum slcerostin to sex hormones (Garnero et al, 2013;Szulc et al, 2013;Yamamoto et al, 2013;Lim et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Sclerostin and Its Associations With Bone Metabolism Markers and Sex Hormones in Healthy Community-Dwelling Elderly Individuals and Adolescents

Gao

et al. 2020

Front. Cell Dev. Biol.

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Sclerostin is an important regulator of bone mass involving Wnt/β-catenin signaling pathway. We aimed to obtain the profile of serum sclerostin level and explore its associations with bone metabolism markers and sex hormones in healthy communitydwelling Chinese elderly individuals and adolescents. A cross-sectional study was performed in three communities in Shanghai. In all, 861 participants, including 574 healthy elderly individuals, and 287 healthy adolescents, were recruited. The levels of serum sclerostin, procollagen type 1 N-terminal propeptide (P1NP), β-CrossLaps of type I collagen containing cross-linked C-telopeptide (β-CTX), parathyroid hormone (PTH), 25-hydroxyvitamin D [25(OH)D], estradiol (E 2 ), testosterone (T), and sex hormonebinding globulin (SHBG) were measured in blood samples from all participants. Median sclerostin level was higher in males than in females and in elderly individuals than in adolescents (elderly males: 54.89 pmol/L, elderly females: 39.95 pmol/L, adolescent males: 36.58 pmol/L, adolescent females: 27.06 pmol/L; both P < 0.05). In elderly individuals, serum sclerostin was positively correlated with age (β = 0.176, P < 0.001) and T (β = 0.248, P = 0.001), but negatively associated to P1NP (β = −0.140, P = 0.001). In adolescents, circulating sclerostin was significantly and positively associated with P1NP (β = 0.192, P = 0.003). The directions of the association between sclerostin and P1NP were opposite in Chinese elderly individuals and adolescents, which may reflect that sclerostin plays distinct roles in different functional states of the skeleton. Our findings revealed the rough profile of circulating sclerostin level in general healthy Chinese population and its associations with bone metabolism markers and sex hormones, which may provide a clue to further elucidate the cross action of sclerostin in bone metabolism and sexual development.

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Section: Introductionmentioning

confidence: 99%

Sclerostin and Its Associations With Bone Metabolism Markers and Sex Hormones in Healthy Community-Dwelling Elderly Individuals and Adolescents

Gao

et al. 2020

Front. Cell Dev. Biol.

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“…In a cross-sectional study of 106 T1DM subjects (12.2 ± 4 years), along with 80 controls, serum sclerostin and dickkopf-1 (DKK-1; another inhibitor of the Wnt/beta-catenin pathway) significantly increased (69). However, these findings were not confirmed in another cross-sectional study of 40 T1DM children (age 13.04 ± 3.53 yr) and 40 controls (70).…”

Section: Introductionmentioning

confidence: 99%

Skeletal growth and bone mineral acquisition in type 1 diabetic children; abnormalities of the GH/IGF-1 axis

Raisingani

Preneet

Kohn

et al. 2017

Growth Hormone & IGF Research

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Type 1 Diabetes Mellitus (T1DM) is one of the most common chronic diseases diagnosed in childhood. Childhood and adolescent years are also the most important period for growth in height and acquisition of skeletal bone mineral density (BMD). The growth hormone (GH)/insulin like growth factor -1 (IGF-1) axis which regulates growth, is affected by T1DM, with studies showing increased GH and decreased IGF-1 levels in children with T1DM. There is conflicting data as to whether adolescents with TIDM are able to achieve their genetically-determined adult height. Furthermore, data support that adolescents with T1DM have decreased peak BMD, although the pathophysiology of which has not been completely defined. Various mechanisms have been proposed for the decrease in BMD including low osteocalcin levels, reflecting decreased bone formation; increased sclerostin, an inhibitor of bone anabolic pathways; and increased leptin, an adipocytokine which affects bone metabolism via central and peripheral mechanisms. Other factors implicated in the increased bone resorption in T1DM include upregulation of the osteoprotegerin/ receptor-activator of the nuclear factor-κB ligand pathway, elevated parathyroid hormone levels, and activation of other cytokines involved in chronic systemic inflammation. In this review, we summarize the clinical studies that address the alterations in the GH/IGF-I axis, linear growth velocity, and BMD in children and adolescents with T1DM; and we review the possible molecular mechanisms that may contribute to an attenuation of linear growth and to the reduction in the acquisition of peak bone mass in the child and adolescent with T1DM.

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“…Previous studies have identified that the deficiency of vitamin D is strongly connected with diabetes mellitus type 1 45,46 and that the death of islet cells and its complements can be easily avoided by the vitamin D, which in turn, will promote the production of insulin. 47,48 Hence, beta cells can be negatively implicated by the lower level of 25(OH)D3.…”

Section: Discussionmentioning

confidence: 99%

Type 1 diabetes mellitus (T1DM) in toddlers and schoolchildren in Najran region, Southwestern Saudi Arabia

Shalayel¹

2017

AMJ

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High Sclerostin and Dickkopf-1 (DKK-1) Serum Levels in Children and Adolescents With Type 1 Diabetes Mellitus

Abstract: Our study highlighted (1) the high serum levels of DKK-1 and sclerostin in T1DM children and their relationship with altered glycemic control and (2) the effect of CSII on improvement of glycemic control and bone health in T1DM children.

Cited by 74 publications

References 33 publications

Sclerostin and Its Associations With Bone Metabolism Markers and Sex Hormones in Healthy Community-Dwelling Elderly Individuals and Adolescents

Sclerostin and Its Associations With Bone Metabolism Markers and Sex Hormones in Healthy Community-Dwelling Elderly Individuals and Adolescents

Skeletal growth and bone mineral acquisition in type 1 diabetic children; abnormalities of the GH/IGF-1 axis

Type 1 diabetes mellitus (T1DM) in toddlers and schoolchildren in Najran region, Southwestern Saudi Arabia

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