High-Risk Human Papillomavirus Reduces the Expression of MicroRNA-218 in Women with Cervical Intraepithelial Neoplasia

Li, Y; Liu, J; Yuan, Cunzhong; Cui, Baoxia; Zou, Xiong; Qiao, Yong

doi:10.1177/147323001003800518

Cited by 43 publications

(36 citation statements)

References 35 publications

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“…Notably, cervical intraepithelial neoplasia and cervical carcinoma cells with high-risk HPV infection compared to intermediate-or low-risk HPV infections also showed reduced miRNA 218 expression (21,22). Based on the current knowledge of other tumors, the downregulation of miRNA 125a-5p and miRNA 218 supposedly increases proliferation by loss of the tumor suppressive activity in JAs.…”

Section: Discussionmentioning

confidence: 96%

Preliminary analysis of different microRNA expression levels in juvenile angiofibromas

2014

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Abstract. Juvenile angiofibroma (JA) is a rare fibrovascular tumor affecting, almost exclusively, adolescent males. The finding of frequent β-catenin-mutations in JAs emphasized the significance of the Wnt-signaling pathway in tumor pathogenesis. In the last decade, microRNAs (miRNAs or miRs) have been found to be involved in cancer pathogenesis by post-transcriptional regulation of gene expression and have not been analyzed in JAs thus far. In the present study, the expression of 4 miRNAs (hsa-let-7d, hsa-miR-98, hsa-miR-125a-5p and hsa-miR-218) was analyzed in 13 JAs and 3 deepithelized inferior nasal turbinates that were used as control tissue. The miRNA expression of hsa-let-7d (P= 0.158) and hsa-miR-98 (P= 0.069) was not statistically different between the two tissue types, however, a significant decrease in expression was observed for hsa-miR-125a-5p (P= 0.037) and hsa-miR-218 (P= 0.009) in JAs compared to inferior nasal turbinates. As downregulation of miRNA 218 has been recently shown to result in stabilization and nuclear accumulation of β-catenin, the present data indicates further evidence for the importance of the Wnt-signaling pathway in JAs.

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Section: Discussionmentioning

confidence: 96%

Preliminary analysis of different microRNA expression levels in juvenile angiofibromas

2014

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“…In vitro and in vivo studies demonstrated that miR-218 is down-regulated by E6 oncoprotein in both precancerous lesions and cervical cancers. In an in vivo study, Li's group [68] proposed to investigate whether there is a correlation between HPV16 infection and miR-218 down-regulation and to evaluate the relationship between miR-218 expression and CIN staging. Seventy-eight CIN cases were included in this study.…”

Section: High-risk Hpv Infection Modulates Mirna Expression In Cervicmentioning

confidence: 99%

The Role of miRNAs in Diagnosis, Prognosis and Treatment Prediction in Cervical Cancer

Bălăcescu¹,

Bălăcescu²,

Baldasici³

et al. 2017

Colposcopy and Cervical Pathology

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Cervical cancer represents one of the major problems of health women worldwide, especially in the developing countries. If discovered in its earliest stages, cervical cancer is successfully treatable; however, due to lack of proper implementation of screening programs, the majority of cervical cancer patients are diagnosed in advanced stages, which dramatically influence their outcome. Almost a half of these patients will suffer recurrence or metastasis in the following 2 years after therapy. If there are no immediate prospects in terms of developing new or more effective therapies, identifying new tools for early diagnosis, prognosis and treatment prediction remains a big challenge for cervical cancer. miRNAs have been validated to be key players in cell physiology, alterations in miRNA expression being associated with cancer progression and response to therapy. Cervical cancer studies have showed that alterations of miRNA expression can be identified in tumor tissues, exfoliated cervical cells and patients serum and that their transcription pattern is regulated by the present HPV genotype. Furthermore, miRNAs have been associated with patients response to therapy, therefore suggesting their potential to be used as biomarkers for cervical cancer diagnosis, prognosis and treatment response.

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“…MiR-218 is remarkably down-regulated in the HPV positive cell lines, cervical lesions and cancer tissues. It may also be involved in cervical intraepithelial neoplasia (CIN) staging, due to its lower expression levels in patients with high-risk CIN than in those with low-risk CIN [30]. Decreased miR-218 expression was also connected with advanced clinical stage, lymph node metastasis, and poor prognosis in cervical cancer [31,32] and pancreatic ductal adenocarcinoma [12,33].…”

Section: Lower Expression Of Mir-218 In Malignant and Metastatic Tumomentioning

confidence: 99%

MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications

Zhang

Waye

et al. 2015

Experimental Cell Research

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High-Risk Human Papillomavirus Reduces the Expression of MicroRNA-218 in Women with Cervical Intraepithelial Neoplasia

Cited by 43 publications

References 35 publications

Preliminary analysis of different microRNA expression levels in juvenile angiofibromas

Preliminary analysis of different microRNA expression levels in juvenile angiofibromas

The Role of miRNAs in Diagnosis, Prognosis and Treatment Prediction in Cervical Cancer

MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications

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