High‐risk HPV types in lesions of the uterine cervix of female commercial sex workers in the Philippines

Miyashita, Michiko; Agdamag, Dorothy M.; Sasagawa, Toshiyuki; Matsushita, Kazuhiro; Salud, Lourdes Ma.; Salud, Calixto O.; Saikawa, Kunikazu; Leano, Prisca Susan A.; Pagcaliwagan, Teresita; Acuna, Jessica; Ishizaki, Azumi; Kageyama, Seiji; Ishiguro, Hiroshi

doi:10.1002/jmv.21416

Cited by 29 publications

(43 citation statements)

References 41 publications

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“…The prevalence of HPV infection in female CSWs from other countries was 57% in the Philippines [11], 39% in Spain [12], 32% in Australia [13] and 48% in Japan [14]. In our previous data [15], the prevalence of HPV infection in high-risk women was 47% with the Hybrid Capture II method (Digene Diagnostics).…”

Section: Resultsmentioning

confidence: 99%

“…[16], the prevalence of HPV infection for female university students in Busan was 15.2% and the common HPV genotypes were HPV-51, -53, -56, -16 and -52. In CSWs in the Philippines, HPV-52 was the most prevalent genotype and other dominant types were HPV-66, -16, -45 and -67 [11]. Among general gynecology practices in South Taiwan, the prevalent genotypes were HPV-16, -52, -58, -18 and -51 [19].…”

Section: Resultsmentioning

confidence: 99%

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Prevalence of human papillomavirus infection and genotype distribution among high-risk Korean women for prospecting the strategy of vaccine development

Rhee

Shin²,

Kim³

et al. 2010

Virol J

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We investigated the prevalence of human papillomavirus (HPV) infection and the distribution of high-risk HPV genotypes among 2,308 high-risk Korean women to predict how much the current prophylactic HPV vaccines might affect the prevention of cervical cancer in Korea. HPV DNA was detected in 939 women (40.7%) but only one-third of women were positive for HPV-16 and/or HPV-18, the genotypes used for developing the HPV vaccines. Thus, the development of area-specific HPV vaccines based on dominant HPV genotypes in our country is needed for preventing HPV infection and the development of premalignant lesions in the cervix of Korean women. FindingsInfection with certain types of human papillomavirus (HPV) is recognized as a causal and necessary factor for developing cervical cancer [1,2], which is the fourth of the most common cancer in South Korean women [3]. More than 140 different HPV genotypes have been characterized and approximately 50 of these genotypes are known to infect the genital tract and be oncogenic or high-risk (HR) types . HR genotypes are significantly associated with progression to invasive cervical cancer [2,4]. Therefore, assessment of the HPV genotypic spectrum among sexually active women is important for predicting public health problems such as the risks of developing cervical intraepithelial neoplasia and cervical cancer [5,6].HPV-16, the most common HR type, is detected in 50 -60% of high-grade squamous intraepithelial lesions and invasive cervical cancers and HPV-18 is followed by an incidence of 10 -20% [4,7]. Thus, HPV-16 and -18 are considered as the types responsible for causing most cervical cancers in many countries [4,7]. Clinical trials have reported that these vaccines can protect many uninfected women from developing precancerous cervical lesions caused by 9]. In spite of their high effectiveness to reduce the incidence of cervical cancer, the usefulness of these vaccines is still being debated because of the differences in the geographical distribution of HPV genotypes [10].Vaccines against HPV-16 and -18 have been developed to help the prevention of cervical cancer and the use of Merck's Gardasil (the quadrivalent vaccine for ) and GSK's Cervarix (the bivalent vaccine for HPV-16 and -18) have been licensed by the Korea Food and Drug Administration. Populationbased study for the distribution of HPV genotype is needed to predict how much these vaccines might influence to the prevention of cervical cancer.In the present study, the prevalence and distribution of HPV genotypes among high-risk women, which are called as commercial sex workers (CSWs) by other countries, were examined to predict whether the developed HPV vaccines are sufficient for preventing HPV infection and the development of premalignant lesions of the cervix in South Korea. A cohort of 2,308 high-risk women visiting for regular sexually transmitted infection testing in public health centers in four different regions (Seoul, Busan, Gwangju and Jeollanamdo) was enrolled in this study. Specimens were collecte...

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Prevalence of human papillomavirus infection and genotype distribution among high-risk Korean women for prospecting the strategy of vaccine development

Rhee

Shin²,

Kim³

et al. 2010

Virol J

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“…In all studies the majority of FSWs were less than 20 years old at the age of sexual initiation: Africa 16.7 years old [16]; Americas 9-22 years [18, 27]; Europe: 16 years [24]; and in the Western Pacific 15-20 years of age [15, 23, 28]. Eastern Mediterranean regions did not give a specific age but indicated that a majority were less than 20 years old [19].…”

Section: Resultsmentioning

confidence: 99%

Cervical HPV Infection in Female Sex Workers: A Global Perspective

Soohoo¹,

Blas²,

Byraiah³

et al. 2013

TOAIDJ

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Introduction: Approximately 291 million women worldwide are HPV DNA carriers. Studies have indicated that having multiple sexual partners may lead to higher HPV transmission. Thus female sex workers (FSWs) may be at greater risk of infection compared to the general population. Herein we review publications with data on FSW cervical HPV test results. We also examine variations of HPV prevalence and risk behaviors by region. Knowledge of prevalent HPV types in FSWs may lead to improved prevention measures and assist in understanding vaccination in high-risk groups.Methods: We conducted a review of the literature by searching PUBMED using the terms “prostitution” or “female sex workers”, “human papillomavirus” or “HPV”, and “prevalence” or “PCR” to find articles. We excluded studies without HPV testing or HPV type specific results, or unconventional HPV testing.Results: A total of 35 peer-reviewed publications were included in our review. High risk HPV types 16 and 18 ranged from 1.1-38.9‰ in prevalence. In addition to high-risk HPV types, newer studies reported non-carcinogenic HPV types also of high prevalence. The most prevalent HPV types reported among FSWs included HPV 6 (11.5%), 16 (38.9%), 18 (23.1%), 31 (28.4%), 52 (32.7%), and 58 (26.0%).Conclusions: Female sex workers have an overall high prevalence of HPV infection of high-risk types as evident through various testing methods. FSWs are thought to be at increased risk of cervical cancer because of high HPV exposure. This highlights the need for HPV and cervical prevention campaigns tailored to FSWs.

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“…The prevalence of cervical HPV is comparable to that observed in FSW in Japan (48%)[31], Korea (47%)[23], Tunisia 43.8%[32], Senegal (43%)[33], and Bulgaria (43.4%)[34], but somewhat lower than other locales including Vietnam (85%)[6], Kenya (55.6%)[35], Peru 65.8%[36] and the Philippines (57.2%)[9]. The mean age of FSW in these studies ranged from 24–31 years old, similar to our study (mean 26 years old).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, several studies have reported that the prevalence of single or multiple HPV infections and HPV viral load was higher among women infected with HIV [19,21,22]. Women engaged in sex work have multiple sex partners, and are consequently at higher risk of both HIV and HPV infection [6,9,23,24]. Understanding the determinants of cervical HPV infection is an essential step in developing effective interventions for the prevention of infection, and ultimately cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

Cervical human papillomavirus infection among young women engaged in sex work in Phnom Penh, Cambodia: prevalence, genotypes, risk factors and association with HIV infection

et al. 2012

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Background Although cervical cancer is the leading cancer in Cambodia, most women receive no routine screening for cervical cancer and few treatment options exist. Moreover, nothing is known regarding the prevalence of cervical HPV or the genotypes present among women in the country. Young sexually active women, especially those with multiple sex partners are at highest risk of HPV infection. We examine the prevalence and genotypes of cervical HPV, as well as the associated risk factors among young women engaged in sex work in Phnom Penh, Cambodia. Methods We conducted a cross-sectional study among 220 young women (15–29 years) engaged in sex work in different venues including brothels or entertainment establishments, and on a freelance basis in streets, parks and private apartments. Cervical specimens were collected using standard cytobrush technique. HPV DNA was tested for by polymerase chain reaction (PCR) and genotyping using type-specific probes for 29 individual HPV types, as well as for a mixture of 10 less common HPV types. All participants were also screened for HIV status using blood samples. Multivariate logistic regression analyses were conducted to assess risk factors for any or multiple HPV infection. Results The prevalence of cervical HPV 41.1%. HPV 51 and 70 were the most common (5.0%), followed by 16 (4.6%), 71 (4.1%) and 81 (3.7%). Thirty-six women (16.4%) were infected with multiple genotypes and 23.3% were infected with at least one oncogenic HPV type. In multivariate analyses, having HIV infection and a higher number of sexual partners were associated with cervical HPV infection. Risk factors for infection with multiple genotypes included working as freelance female sex workers (FSW) or in brothels, recent binge use of drugs, high number of sexual partners, and HIV infection. Conclusions This is the first Cambodian study on cervical HPV prevalence and genotypes. We found that HPV infection was common among young FSW, especially among women infected with HIV. These results underscore the urgent need for accessible cervical cancer screening and treatment, as well as for a prophylactic vaccine that covers the HPV subtypes present in Cambodia.

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High‐risk HPV types in lesions of the uterine cervix of female commercial sex workers in the Philippines

Cited by 29 publications

References 41 publications

Prevalence of human papillomavirus infection and genotype distribution among high-risk Korean women for prospecting the strategy of vaccine development

Prevalence of human papillomavirus infection and genotype distribution among high-risk Korean women for prospecting the strategy of vaccine development

Cervical HPV Infection in Female Sex Workers: A Global Perspective

Cervical human papillomavirus infection among young women engaged in sex work in Phnom Penh, Cambodia: prevalence, genotypes, risk factors and association with HIV infection

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