High Risk HPV Detected in Oral Cavity of Children in a Set Population of Karachi

Irshad, Faisal; Baig, Saeeda; Syed, Serajuddaula; Lucky, Mohammad Haris

doi:10.9734/isrr/2015/14841

Cited by 2 publications

(4 citation statements)

References 10 publications

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“…This dissimilarity and the increased inconsistencies in the prevalence of oral HR‐HPV infection were not surprising, given the variations in the study populations. This study reported that HPV16 is the most prevalent genotype, followed by HPV18, which is similar to the other national and international data 6,7,18,20,21,24–26 except for HPV39 and HPV51, which were not reported earlier in any local studies; however, a study carried out in Europe and Brazil reported non‐HPV16 and HPV18 was the most common genotypes in the samples 22,27 …”

Section: Discussionsupporting

confidence: 89%

“…The prevalence of oral HR‐HPV infection observed in this study (11%) was consistent with some studies, 14–17 whereas in contrast with the large‐scale studies from the United States carried out in >5000 participants, which reported an overall prevalence of OHPV infection of 6.9%, 18 China (0.67%), Costa Rica (1.3%), United Kingdom (2.2%), Italy (4%), and Brazil (3.9%), respectively 6,19–22 . The prevalence observed in this study was lower than that observed in the study previously conducted in Pakistan, which was 24.5% among participants attending the dental department 23 whereas, higher in comparison to the study conducted by Irshad et al 24 reported a prevalence of 7.6% in school‐going children in Karachi, Pakistan. This dissimilarity and the increased inconsistencies in the prevalence of oral HR‐HPV infection were not surprising, given the variations in the study populations.…”

Section: Discussioncontrasting

confidence: 68%

“…1.85-28.16) and 5.17 The prevalence of oral HR-HPV infection observed in this study (11%) was consistent with some studies, [14][15][16][17] whereas in contrast with the large-scale studies from the United States carried out in >5000 participants, which reported an overall prevalence of OHPV infection of 6.9%, 18 China (0.67%), Costa Rica (1.3%), United Kingdom (2.2%), Italy (4%), and Brazil (3.9%), respectively. 6,[19][20][21][22] The prevalence observed in this study was lower than that observed in the study previously conducted in Pakistan, which was 24.5% T A B L E 1 Information and association of HR-OHPV with sociodemographic, addictive habits, and oral hygiene status among participants attending the dental department 23 whereas, higher in comparison to the study conducted by Irshad et al 24 reported a prevalence of 7.6% in school-going children in Karachi,…”

Section: Resultsmentioning

confidence: 88%

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Molecular characterization and risk factors of oral high‐risk human papillomavirus among females in Punjab, Pakistan

Minhas

Kashif²,

Rehman³

et al. 2022

Journal of Medical Virology

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Background The development of oral and oropharyngeal cancers is associated with human papillomavirus (HPV) infection. However, debate exists about the prevalence of high‐risk oral HPV (HR‐HPV) and its associated risk factors. This study evaluated the distribution of genotypes and associated risk factors of oral HR‐HPV infection in the normal oral mucosa of the Pakistani female population with general gynecological problems. Methods A total of 200 females from a regional gynecological hospital in Pakistan were included in this cross‐sectional study. A self‐administered questionnaire was carried out, followed by the study participants' oral and dental examinations. Whole saliva was collected by a drooling method. The viral DNA extraction and oral HR‐HPV genotyping were detected via real‐time polymerase chain reaction. Results Among the 200 females (mean age, 37.76 years), 22 females (11%) were positive for oral HR‐HPV DNA. Single oral HR‐HPV infection was seen in 8%, whereas co‐infection was observed in 3% with HPV16 and HPV18 most common genotypes. Comparison of the risk factors like oral sex history odds ratio (OR 8.21, 95% confidence interval [CI] 1.85–28.16; p < 0.005), and open‐mouth kissing (OR, 5.17; 95% CI 1.48–27.41; p = 0.005) with oral HR‐HPV infection was found to be significantly associated. Conclusion In Pakistan, oral HR‐HPV‐positive infection is not uncommon; HPV16 and HPV18 are the most frequent genotypes. Furthermore, this study also provides data that oral HR‐HPV positive infection was significantly associated with sexual behaviors. Therefore, preventive health efforts, like health education and vaccination, should be practiced.

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Section: Discussionsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 68%

Section: Resultsmentioning

confidence: 88%

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Molecular characterization and risk factors of oral high‐risk human papillomavirus among females in Punjab, Pakistan

Minhas

Kashif²,

Rehman³

et al. 2022

Journal of Medical Virology

View full text Add to dashboard Cite

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“…Five multiple studies, mostly from Karachi, Pakistan [24], [25], [26], [27] [28], evaluated the prevalence of HPV infection in normal oral mucosa and stated a 9.7% prevalence of HPV (SD = 8.20; SE = 3.68) (Table 3) whereas a total of 10 studies [26], [28], [29], [30], [31], [32], [33], [34], [35], [36] from all over Pakistan were carried out on 828 OC cases reporting that 330 (40%) were positive for HPV (SD = 27.4; SE = 8.69). The mainstream of OC studies (n = 7) was from Karachi which screened n = 613 participants and revealed that n = 224 (36.5%) of OC cases were positive for HPV infection.…”

Section: Hpv In Normal Oral Mucosa and Oral Cancersmentioning

confidence: 99%

Prevalence and Current Scenario of HPV in Pakistan: A Systematic Review and Meta-analysis

Minhas

Sajjad

Chaudhry

et al. 2022

Open Access Maced J Med Sci

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AIM: The present study was designed to compile and screen data regarding HPV-related reported diseases to evaluate the status of HPV infection in Pakistan. METHODS: The literature on the prevalence of HPV in Pakistan was searched in Google Scholar and other search engines using various keywords. RESULTS: A total of 39 studies published from 2007 to 2018 were reviewed. About 7341 participants have been screened for HPV in Pakistan for the past 11 years, and according to this meta-analysis, the reported HPV prevalence was 23.1%. The highest HPV prevalence rate was observed among cervical cancer cases (80.4%) followed by normal cervical region (61.8%) and oral cancer (40.4%), respectively. CONCLUSION: The high prevalence of HPV in Pakistan reflects the raised burden of HPV-associated diseases. The health-care system needs to be more organized in terms of awareness and screening programs, diagnosis, and treatment of the disease to reduce the burden of HPV in Pakistan.

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High Risk HPV Detected in Oral Cavity of Children in a Set Population of Karachi

Cited by 2 publications

References 10 publications

Molecular characterization and risk factors of oral high‐risk human papillomavirus among females in Punjab, Pakistan

Molecular characterization and risk factors of oral high‐risk human papillomavirus among females in Punjab, Pakistan

Prevalence and Current Scenario of HPV in Pakistan: A Systematic Review and Meta-analysis

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