High-risk and multiple human papillomavirus (HPV) infections in cancer-free Jamaican women

Watt, Angela; Garwood, David; Jackson, Maria; Younger, Novie; Ragin, Camille; Smikle, Monica; Fletcher, Horace; McFarlane‐Anderson, Norma

doi:10.1186/1750-9378-4-s1-s11

Cited by 25 publications

(31 citation statements)

References 33 publications

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“…Interestingly, HRHPV‐type distribution of our samples was not exclusively focused on current types 16 and 18 but implicated other HRHPV types (i.e. 31,33,35,51) according to recent reports from the African Caribbean Cancer Consortium . As reported in the literature, positive HIV status was significantly associated with HRHPV infections as all HIV‐seropositive Afro‐Caribbean patients had a SCC located on the anogenital area…”

Section: Discussionsupporting

confidence: 61%

Squamous cell carcinoma in the Afro‐Caribbean community: an 11‐year retrospective study

Cordel

Bonnecarrere

Tressières³

2017

Acad Dermatol Venereol

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Squamous cell carcinoma is the most frequent skin cancer in Black people. Its incidence is not known in the Afro-Caribbean population. In Guadeloupe, the largest island of the Lesser Antilles, the annual age-adjusted incidence of SCC was estimated to be 15.0 per 100 000 residents, 95% CI:[13.8; 16.2]. In the Guadeloupean Afro-Caribbean community, SCC seems to more frequently occur in the anogenital area, due to HPV infection. These results support to include a routine genital urinary examination in the skin cancer screening of people of Afro-Caribbean descent.

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Section: Discussionsupporting

confidence: 61%

Squamous cell carcinoma in the Afro‐Caribbean community: an 11‐year retrospective study

Cordel

Bonnecarrere

Tressières³

2017

Acad Dermatol Venereol

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“…However, HPV infection does not always develop into invasive cancer 8 (29,30), and the cases diagnosed with cervical cancer do not always have HPV infection (31). To this end, although HPV testing is an effective way in cervical cancer screening, stand-alone still cannot be a once-for-all method in a primarily-initiated single round mass population screening (32,33).…”

Section: Discussionmentioning

confidence: 99%

DNA Ploidy Cytometry Testing for Cervical Cancer Screening in China (DNACIC Trial): a Prospective Randomized, Controlled Trial

Tong

Shen²,

Wang³

et al. 2009

Clinical Cancer Research

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Purpose: This randomized, controlled trial was designed to determine whether the DNA cytometry testing is superior to the conventional cytologic testing for mass cervical cancer screening. Experimental Design: After approval by the institutional ethics review boards from three separate screening centers, a total of 23,993 Chinese women ages 20 to 65 years were randomly assigned into one of the two groups: a DNA cytometry testing group (11,999 women) and a cytologic testing group (11,994 women). Each woman underwent the other testing after first attending the assigned screening test. Women with positive results after assigned testing additionally underwent colposcopy and human papillomaviruses detections, and those with cervical precancerous or cancerous lesions received appropriate treatment. Sensitivity and specificity estimates were adjusted for verification bias. Analyses were by intention to treat and per protocol ways. Results: In the cytometric DNA testing group, cervical cancer was diagnosed in 40 subjects, compared with 24 subjects in the cytologic testing group [hazard ratio for the detection of advanced cancer in the DNA cytometry testing group, 0.42; 95% confidence interval (CI), 0.27-0.60]. The sensitivity of the DNA cytometry testing for cervical cancer was 91.7% (95% CI, 64.3-95.8), whereas the sensitivity of cytologic testing was 44.5% (95% CI, 25.2-61.3; P = 0.008). The specificity was 54.1% (95% CI, 31.6-69.0) for DNA cytometry testing and 70.6% (95% CI, 46.8-82.5; P = 0.003) for cytologic testing. The sensitivity of both tests used together was 100%, and the specificity was 91.8%. A total of 187 subjects reported mild to severe adverse events after treatment with positive results in 319 women. Conclusions: Our results highlight the benefit of the DNA cytometry testing strategy in mass cervical cancer screening with greater sensitivity and positive predicted value than the conventional cytologic testing in developing settings. (Clin Cancer Res 2009;15(20):6438-45) Cervical cancer remains the leading cause of cancer death among women in low-resource countries. Approximately 320,000 of cervical cancer cases are diagnosed in the developing world every year, of which takes over 80% of all the cases of cervical cancer that are diagnosed annually worldwide (1). As thus, how the cervical cancer is sieved through effective methods during mass population screening is an essential question for global researchers investigating the effectiveness October 14, 2009; DOI: 10.1158/1078-0432.CCR-09-1689 and accuracy of currently available means-particularly for predicting the emergence of the cancer after a single round of screening.Cervical cytologic testing with the Bethesda System has proved to be one of the most successful examples of cancer screening over the simple Papanicolaou (Pap) smear test and has resulted in significant decreases in incidence and mortality from cervical cancer (2). Besides, numerous studies recommended that human papillomavirus (HPV) testing is an appropriate method when...

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“…accounts for 87% of squamous cell carcinomas 8,9 , while HPV18 accounts for 86% of adenocarcinomas 4 A C C E P T E D M A N U S C R I P T…”

Section: Accepted Manuscript Introductionmentioning

confidence: 99%

High prevalence of HPV59 in cytologically abnormal cervical samples

Chan

Feng

et al. 2015

Experimental and Molecular Pathology

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High-risk and multiple human papillomavirus (HPV) infections in cancer-free Jamaican women

Cited by 25 publications

References 33 publications

Squamous cell carcinoma in the Afro‐Caribbean community: an 11‐year retrospective study

Squamous cell carcinoma in the Afro‐Caribbean community: an 11‐year retrospective study

DNA Ploidy Cytometry Testing for Cervical Cancer Screening in China (DNACIC Trial): a Prospective Randomized, Controlled Trial

High prevalence of HPV59 in cytologically abnormal cervical samples

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