High resolution ultrasound perfusion imaging of therapeutic angiogenesis

Rissanen, Tuomas T.; Koripisalo, Petra; Karvinen, Henna; Liimatainen, Timo; Laidinen, Svetlana; Gröhn, Olli; Ylä‐Herttuala, Seppo

doi:10.1016/j.ijcard.2007.03.022

Cited by 17 publications

(24 citation statements)

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“…Doppler image shows increased blood flow in large arteries and veins whereas CPS imaging has a superior resolution, and perfusion in enlarged capillaries is also visible. 15 Notably, no visible muscle edema was detected by ultrasound imaging after AAV-VEGF-A gene transfer. No changes in perfusion were detected in AAV-LacZtransduced muscles 6 months after ischemia and gene transfer (Figures 2e and f).…”

Section: Aav-vegf-a Increases Local Perfusion In Skeletal Musclesmentioning

confidence: 96%

“…15,29 CPS method uses non-linear fundamental frequencies, which results in better spatial resolution and high sensitivity to contrast media, and provides improved tissue subtraction than previous ultrasound perfusion imaging techniques. 30,31 Transversal images of semimembranosus muscles of both limbs were captured after a single bolus (0.5 ml) of SonoVue contrast microbubbles (Bracco, Milan, Italy) with the following parameters at 8.0 MHz: power À16 dB, mechanical index 0.31, CPS gain À10 and depth 20 mm.…”

Section: Ultrasound Imagingmentioning

confidence: 99%

“…Muscle perfusion was quantified with the DataPro 2.13 software (Noesis, Courtaboeuf, France) and the perfusion ratio between transduced muscle and intact muscle was quantified using the maximal signal intensities as previously reported. 15 …”

Section: Ultrasound Imagingmentioning

confidence: 99%

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Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle

et al. 2011

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Section: Aav-vegf-a Increases Local Perfusion In Skeletal Musclesmentioning

confidence: 96%

Section: Ultrasound Imagingmentioning

confidence: 99%

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Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle

et al. 2011

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“…Relevant analysis software has been developed to analyze ultrasound signal intensity (SI) patterns obtained by imaging continuously prior or subsequent to treatment, and information regarding tissue blood flow and vascular integrity, branching patterns and density will be assessed (8). As reported previously, the information extracted from the CEUS data was similar to that obtained from DCE-MRI (9), and CEUS has numerous benefits, including a sufficient high safety profile that is acceptable for patients with renal failure or an iodine allergy, absence of radiation, easy reproducibility and high temporal resolution (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 80%

Parametric contrast-enhanced ultrasound as an early predictor of radiation-based therapeutic response for lymph node metastases of nasopharyngeal carcinoma

Huang

Zhou

et al. 2014

Molecular and Clinical Oncology

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Abstract. Nasopharyngeal carcinoma (NPC) is a common type of cancer in South East Asia with peculiar epidemiology, pathology, clinical behavior and response to treatment characteristics. To the best of our knowledge, this is the first study to investigate the use of a contrast-enhanced ultrasound (CEUS) as a predictor for the therapeutic response in lymph node metastases of NPC patients treated with radiation-based therapy. Sixty-seven NPC patients with lymph node metastases underwent the lymph nodes CEUS examination twice; pre-and in-treatment (at the 5th fraction radiotherapy), respectively. The CEUS parameters were acquired through Qontrast_4.0 software and mainly included peak intensity (PI) and time to peak (TTP). The response assessment at the lymph nodes revealed a complete response (CR) in 48 patients and partial response (PR) in 19 patients. There was a significant difference in pre-treatment PI (PI pre ) between the patients who showed CR or PR, but the predicted sensitivity and specificity of PI pre was low. The mean in-treatment PI (PI in ) value of the lymph nodes that achieved a CR was 34.24±3.78%, which was significantly higher than the PI in value for PR, 25.62±2.30% (P<0.001). Furthermore, the PI ratio , a PI-quotient, was calculated by dividing the PI in by the corresponding PI pre . The higher PI ratio was also observed in CR lymph nodes (0.81±0.01 vs. 0.66±0.01; P=0.001), and the mean change in PI (PI Δ ; PI Δ = PI pre -PI in ) was smaller in the patients with CR nodes compared to the patients with PR nodes (7.79±3.28 vs. 13.77±1.90%; P=0.000). No difference was observed in TTP pre or TTP in between the CR or PR lymph nodes patients. A receiver operating characteristic curve was constructed to assess the accuracy of the parameters for the prediction of the therapeutic responses. The sensitivity and specificity of PI in in predicting the therapeutic response was 94.3 and 88.2%, and the corresponding figures of the PI ratio were 92.5 and 83.8%, respectively. The CEUS parameters during the early course of radiation-based therapy, PI in and PI ratio , are associated with the therapeutic response of NPC lymph node metastases, with a high predicted sensitivity and specificity, thus yielding the conceivable predictors with the potential to individualize treatment.

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“…Bolus tracking is a common approach for assessment of hemodynamic state across multiple imaging modalities such as magnetic resonance imaging, computer tomography, and ultrasound (Calamante et al, 2002;Reichenbach et al, 1999;Rissanen et al, 2008). The typical analysis strategy is to fit a model function to the first bolus passage (Benner et al, 1997;Kershaw and Cheng, 2011;Kim et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Robust Quantification of Microvascular Transit Times via Linear Dynamical Systems using Two-Photon Fluorescence Microscopy Data

Chinta

Lindvere

Stefanović

2012

J Cereb Blood Flow Metab

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Vascular transit time is an important indicator of microcirculatory health. We present a secondorder-plus-dead-time (SOPDT) model for robust estimation of kinetic parameters characterizing microvascular bolus passage using two-photon fluorescence microscopy (2PFM) in anesthetized rats receiving somatosensory stimulation. This methodology enables quantification of transit time, time-to-peak, overshoot, and rate of bolus passage through the microvascular network. The overall transit time during stimulation, of 2.2±0.1 seconds, was shorter (PB0.0008) than that at rest (2.7 ± 0.2 seconds). When compared with conventional c-variate modeling, the SOPDT modeling yielded better quality of fit both at rest (P < 0.0001) and on activation (P < 0.001).

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High resolution ultrasound perfusion imaging of therapeutic angiogenesis

Cited by 17 publications

References 0 publications

Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle

Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle

Parametric contrast-enhanced ultrasound as an early predictor of radiation-based therapeutic response for lymph node metastases of nasopharyngeal carcinoma

Robust Quantification of Microvascular Transit Times via Linear Dynamical Systems using Two-Photon Fluorescence Microscopy Data

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