Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle

Karvinen, Henna; Pasanen, Eveliina; Rissanen, Tuomas T.; Korpisalo, Petra; Vähäkangas, Elisa; Jaźwa, Agnieszka; Giacca, Mauro; Ylä‐Herttuala, Seppo

doi:10.1038/gt.2011.66

Cited by 69 publications

(62 citation statements)

References 33 publications

(41 reference statements)

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“…Similarly, another polysaccharide, polysialic acid (polySia), forms a large complex (>650 kDa) with fibroblast growth factor 2 (FGF-2) and can enhance FGF-2-mediated cell proliferation when its chain length reaches 17 monosaccharide units [19]. In comparison with exogenous administration of the growth factors, the supply of growth factor-binding polymers successfully harnesses the power of endogenous growth factors while avoiding the side effects of exogenous growth factor degradation and overdosing [20,21]. In the cases of ischemia or wound healing, the levels of growth factors or cytokines significantly increase locally but may easily diffuse away or degrade.…”

mentioning

confidence: 99%

Exploring ‘new’ bioactivities of polymers at the nano–bio interface

Wang

Dong

2015

Trends in Biotechnology

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mentioning

confidence: 99%

Exploring ‘new’ bioactivities of polymers at the nano–bio interface

Wang

Dong

2015

Trends in Biotechnology

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“…The local administration of VEGF has also been associated with reduced scaring and improved muscle regeneration and strength recovery after acute trauma [128]. Sustained VEGF delivery promotes neo-angiogenesis and tissue perfusion recovery, as well as conferring protection from hypoxia and tissue necrosis in ischemic limbs [123], but it may derive into aberrant ECM deposition and undesired fibrosis [129].…”

Section: The Role Of Growth Factors and Cytokines In Skeletal Muscle mentioning

confidence: 99%

Trends in Mesenchymal Stem Cells' Applications for Skeletal Muscle Repair and Regeneration

Caseiro¹,

Pereira²,

Bártolo³

et al. 2015

Progress in Stem Cell Transplantation

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Skeletal muscle injuries are quite frequent in traumatic scenarios, such as war injuries or road-or work-related accidents. The skeletal muscle has good regenerative ability, but the extent or recurrence of muscle injury might impair complete structural and functional recovery. Severe tissue loss overwhelms skeletal muscle´s intrinsic regenerative capabilities and culminates in the development of noncontractile fibrous tissue scar. Conservative RICE -based and surgical treatments show limited efficacy in terms of improving these severe cases outcomes, pressing the need for new approaches on skeletal muscle's therapy. Since the first suggestions of the potential of mesenchymal stem cells for regenerative medicine and tissue engineering, many applications have been explored for a variety of tissues and diseases, including the skeletal muscle, which is the focus of this literature review.

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“…Whereas the vasculature formed by constitutive VEGF-A 165 expression is immature, cessation of the stimulus leads to maturation and acquisition of functional competence. 89,104,105 Considering the complexity of the angiogenic process, in which an initial phase of endothelial sprouting has to be followed by a maturation phase when pericytes and smooth muscle cells are recruited to cover the new endothelial tubes, the promotion of functional neovascularization is a highly ambitious objective, requiring the coordinated action of multiple molecular players. In this respect, a reasonable approach to promote the formation of mature vessels might consist in the combined delivery of different angiogenic genes, acting on both early and late phases of the process.…”

Section: Induction Of Therapeutic Angiogenesismentioning

confidence: 99%

Adeno-Associated Virus Vectors as Therapeutic and Investigational Tools in the Cardiovascular System

Zacchigna

Zentilin

Giacca

2014

Circulation Research

114

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Abstract:The use of vectors based on the small parvovirus adeno-associated virus has gained significant momentum during the past decade. Their high efficiency of transduction of postmitotic tissues in vivo, such as heart, brain, and retina, renders these vectors extremely attractive for several gene therapy applications affecting these organs. Besides functional correction of different monogenic diseases, the possibility to drive efficient and persistent transgene expression in the heart offers the possibility to develop innovative therapies for prevalent conditions, such as ischemic cardiomyopathy and heart failure. Therapeutic genes are not only restricted to protein-coding complementary DNAs but also include short hairpin RNAs and microRNA genes, thus broadening the spectrum of possible applications. In addition, several spontaneous or engineered variants in the virus capsid have recently improved vector efficiency and expanded their tropism. Apart from their therapeutic potential, adeno-associated virus vectors also represent outstanding investigational tools to explore the function of individual genes or gene combinations in vivo, thus providing information that is conceptually similar to that obtained from genetically modified animals. Finally, their single-stranded DNA genome can drive homology-directed gene repair at high efficiency. Here, we review the main molecular characteristics of adeno-associated virus vectors, with a particular view to their applications in the cardiovascular field.

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Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle

Cited by 69 publications

References 33 publications

Exploring ‘new’ bioactivities of polymers at the nano–bio interface

Exploring ‘new’ bioactivities of polymers at the nano–bio interface

Trends in Mesenchymal Stem Cells' Applications for Skeletal Muscle Repair and Regeneration

Adeno-Associated Virus Vectors as Therapeutic and Investigational Tools in the Cardiovascular System

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