High-Resolution Three-Dimensional Contrast-Enhanced Blood Oxygenation Level-Dependent Magnetic Resonance Venography of Brain Tumors at 3 Tesla: First Clinical Experience and Comparison with 1.5 Tesla

Barth, Markus; Nöbauer-Huhmann, I.-M.; Reichenbach, Jürgen R.; Mlynárik, Vladı́mir; Schöggl, Andreas; Matula, Christian; Trattnig, Siegfried

doi:10.1097/01.rli.0000069790.89435.e7

Cited by 56 publications

(54 citation statements)

References 24 publications

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“…It was previously shown that SWI works very well at 3T and even 4T (8,29). At 3T, for example, in the same period of time one could theoretically double the current coverage at Figure 7.…”

Section: Discussionmentioning

confidence: 92%

“…The internal architecture represents the ability of a sequence to show spatial signal heterogeneity within a lesion. The spatial signal heterogeneity within a lesion is thought to represent tissue changes that are related to variance in structure and composition, and was previously described as being increased in SWI and phase imaging (8,23). Only low-signal structures that could be followed on contiguous images and had an apparently cylindrical structure were considered to represent veins.…”

Section: Discussionmentioning

confidence: 99%

“…These characteristics permit SWI to have exquisite sensitivity to the venous vasculature (5), blood products (such as those that occur after hemorrhage), and vascular malformations (6,7). SWI also shows promise for observing tumor vascularity (8,9).…”

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confidence: 99%

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Susceptibility‐weighted imaging to visualize blood products and improve tumor contrast in the study of brain masses

Sehgal

DelProposto

Haddar

et al. 2006

Magnetic Resonance Imaging

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188

148

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Purpose:To evaluate the diagnostic value of susceptibilityweighted imaging (SWI) for studying brain masses. Materials and Methods:SWI is a high-resolution, threedimensional, fully velocity-compensated gradient-echo sequence that uses both magnitude and phase data. Custom postprocessing is applied to enhance the contrast in the magnitude images between tissues with different susceptibilities. This sequence was applied to 44 patients (24 males and 20 females, 15-89 years old, mean age ϭ 50.3 years) with brain masses, pre-and/or postcontrast, and compared with conventional sequences (T1, T1 postcontrast, T2, proton density (PD), fluid-attenuated inversion recovery (FLAIR) and diffusion-weighted imaging (DWI) at 1.5T). Correlation with pathology was obtained in 12 cases. All images were reviewed independently by three radiologists. Results:In the evaluation of tumor visibility, boundary definition, blood products, venous vasculature, architecture, and edema, SWI gave better information than the standard T1-weighted postcontrast images in 11%, 14%, 71%, 73%, 63%, and 75% of the data, respectively, in a subgroup of 38 patients. This demonstrates that the information presented by SWI is complementary in nature to that available from conventional methods. On the whole, SWI was much more sensitive for showing blood products and venous vasculature. SWI showed a useful FLAIR-like contrast and complemented the information obtained by conventional T1 postcontrast sequences regarding the internal architecture of the lesions. Good pathologic correlations were found for blood products as predicted by SWI.Conclusion: SWI should prove useful for tumor characterization because of its ability to better highlight blood products and venous vasculature and reveal new internal architecture.

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“…It was previously shown that SWI works very well at 3T and even 4T (8,29). At 3T, for example, in the same period of time one could theoretically double the current coverage at Figure 7.…”

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Susceptibility‐weighted imaging to visualize blood products and improve tumor contrast in the study of brain masses

Sehgal

DelProposto

Haddar

et al. 2006

Magnetic Resonance Imaging

Self Cite

188

148

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“…Although SWI has been used as an MR venographic method for several years (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26), it has more recently been applied to studies of arterial venous malformations (16,24), occult venous disease (15), multiple sclerosis (20), trauma (25), tumors (21,23,26), and functional brain imaging (14,22). Given the continued increasing clinical interest in this topic, it is important to ensure a complete understanding of the mathematical processes involved in creating SW images.…”

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confidence: 99%

Susceptibility weighted imaging (SWI)

Haacke¹,

Xu²,

Cheng³

et al. 2004

Magnetic Resonance in Med

1,444

1,228

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Susceptibility differences between tissues can be utilized as a new type of contrast in MRI that is different from spin density, T 1 -, or T 2 -weighted imaging. Signals from substances with different magnetic susceptibilities compared to their neighboring tissue will become out of phase with these tissues at sufficiently long echo times (TEs). Thus, phase imaging offers a means of enhancing contrast in MRI. Specifically, the phase images themselves can provide excellent contrast between gray matter (GM) and white matter (WM), iron-laden tissues, venous blood vessels, and other tissues with susceptibilities that are different from the background tissue. Also, for the first time, projection phase images are shown to demonstrate tissue (vessel) continuity. In this work, the best approach for combining magnitude and phase images is discussed. The phase images are high-pass-filtered and then transformed to a special phase mask that varies in amplitude between zero and unity. This mask is multiplied a few times into the original magnitude image to create enhanced contrast between tissues with different susceptibilities.

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“…HR-SW-MR imaging allows for noninvasive visualization of small veins in the human brain at submillimeter resolution and, therefore, is used to depict venous architecture in normal, as well as pathologic, tissue. [1][2][3][4][5][6][7][8] Because the underlying contrast mechanism is associated with the magnetic susceptibility difference between oxygenated hemoglobin (diamagnetic) and deoxygenated hemoglobin (paramagnetic), differences in the state of the blood oxygenation, such as in cerebral veins, result in differences in the bulk magnetic susceptibility of blood (static BOLD effect).…”

mentioning

confidence: 99%

High-Resolution Contrast-Enhanced, Susceptibility-Weighted MR Imaging at 3T in Patients with Brain Tumors: Correlation with Positron-Emission Tomography and Histopathologic Findings

Pinker¹,

Noebauer-Huhmann²,

Stavrou³

et al. 2007

American Journal of Neuroradiology

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High-Resolution Three-Dimensional Contrast-Enhanced Blood Oxygenation Level-Dependent Magnetic Resonance Venography of Brain Tumors at 3 Tesla: First Clinical Experience and Comparison with 1.5 Tesla

Cited by 56 publications

References 24 publications

Susceptibility‐weighted imaging to visualize blood products and improve tumor contrast in the study of brain masses

Susceptibility‐weighted imaging to visualize blood products and improve tumor contrast in the study of brain masses

Susceptibility weighted imaging (SWI)

High-Resolution Contrast-Enhanced, Susceptibility-Weighted MR Imaging at 3T in Patients with Brain Tumors: Correlation with Positron-Emission Tomography and Histopathologic Findings

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