High-Resolution Inductively Coupled Plasma Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Femtosecond laser ablation particle introduction to a liquid sampling-atmospheric pressure glow discharge ionization source

“…Before orbitrap technology, high mass resolution elemental analysis was only possible with FT-ICR instruments or with collision/ reaction cell techniques employing 'chemical resolution' approaches. [16][17][18] Unfortunately, these suffer the disadvantages associated with the magnets required for their operation; size and cryogenic cooling requirement, or the need for various gas-phase reaction chemistries. One of the most important attributes of orbitrap mass analysis is the potential to provide exceedingly high mass resolution with an instrument that has a relatively small footprint; an attribute that lends itself well to the compact LS-APGD ionization source.…”

Coupling of an atmospheric pressure microplasma ionization source with an Orbitrap Fusion Lumos Tribrid 1M mass analyzer for ultra-high resolution isotopic analysis of uranium

“…Over the last 25 years, there have been a couple of reports describing the interfacing of plasma sources to mass spectrometers of far greater mass resolution than SF platforms. 9,10 Specifically, Eyler and co-workers interfaced an ICP source to a 7 T Fourier transform-ion cyclotron resonance (FT-ICR) instrument. 9 To affect such a coupling, extensive increases in the vacuum pumping capacity and additions of ion transfer optics had to be implemented.…”

“…9,10 Specifically, Eyler and co-workers interfaced an ICP source to a 7 T Fourier transform-ion cyclotron resonance (FT-ICR) instrument. 9 To affect such a coupling, extensive increases in the vacuum pumping capacity and additions of ion transfer optics had to be implemented. In this sole publication, the authors demonstrated a mass resolving power of ~10,000, achieved for the separation of 41 K and 40 ArH.…”

Emergence and impact of alternative sources and mass analyzers in plasma source mass spectrometry

“…Fundamentally, FTMS permits truly simultaneous measurements, since ions are not only extracted from a source at once, but also are measured continuously as they cycle through the magnetic field of the FTMS. Even more importantly, FTMS is capable of phenomenal resolving power, 44,45 so spectral interferences should cease to be a problem. Unfortunately, FTMS like the Paul ion trap has limited ion capacity, so its dynamic range is limited.…”

“…Lastly, FTMS instruments are inherently extremely expensive, because they require a very high vacuum and a strong magnetic field. As a result, although a successful coupling of an ICP and FTMS has been achieved, [44][45][46][47][48][49] the method has never enjoyed widespread use. The more recent device termed an Orbitrap can be considered the electrostatic analog of an FTMS and, as such, exhibits similar advantages and drawbacks.…”