High resolution detection of high mass proteins up to 80,000Da via multifunctional CdS quantum dots in laser desorption/ionization mass spectrometry

Nanomaterial-based miniaturized extraction and preconcentration techniques coupled to matrix-assisted laser desorption/ionization mass spectrometry for assaying biomolecules

“…To support this, our group utilized a wide variety of functionalized semiconductor NPs, including ZnS [83,84], Mn 2+ -doped ZnS [85], CdS [86,87], CdSe [88], Cd 2+ -doped CNTs, CdS [89], and ZnSe [90,91], as affinity and concentrating probes for the analysis of peptides and proteins by MALDI-MS. The unique physico-chemical properties of NPs can be controlled and effective trapping or affinity agents made by modifying the surfaces of NPs with suitable organic ligands.…”

“…Similarly, ZnS-N 3 -NPs were used as affinity probes for the direct (separation/washing free) analysis of milk proteins and ubiquitin-like proteins from oyster mushroom [84]. Also, the 3-MPA-capped CdS-QDs were effectively used as matrix and affinity probes for the analysis of peptides and proteins by MALDI-MS [86]. Importantly, the mass resolution of large proteins (BSA, human serum albumin and transferrin, 66000-80000 Da) was greatly enhanced by using CdS-QDs as the matrix.…”

Quantifying the degradation of extracellular polysaccharides of Escherichia coli by CdS quantum dots

“…The strong (orange) emission peak was observed at 565 nm, indicating that the 3-MPA was successfully attached onto the surfaces of CdS QDs and these results are in good agreement with literature. 32,35 Ke et al report based on their FTIR analysis, that following their protocol would ultimately result in the capping of 6-MPA on CDs QDS surfaces. 32 Hence it is not unusual that we also find evidence of capping with 3-MPA.…”

“…32,35 Ke et al report based on their FTIR analysis, that following their protocol would ultimately result in the capping of 6-MPA on CDs QDS surfaces. 32 Hence it is not unusual that we also find evidence of capping with 3-MPA. Supporting figure S2(C) shows the typical green fluorescence in the presence of near UV light illumination exhibited by CdS QDs.…”

Synthesis and characterization of supported silica nano hollow spheres with CdS quantum dots

“…Semiconductor nanocrystals from groups II-VI and III-V elements such as, CdSe [18], CdTe [19], CdS [20] and ZnSe [21], often referred to as "quantum dots" (QDs). These compounds show quantum size effects and have been widely studied in recent years owing to their unusual physical properties and wide range of potential applications [22][23][24].…”