High resolution computed tomography of the vertebrae yields accurate information on trabecular distances if processed by 3D fuzzy segmentation approaches

Krebs, Andreas; Graeff, Christian; Frieling, Isolde; Kurz, Bodo; Timm, Wolfram; Engelke, Klaus; Glüer, Claus‐C.

doi:10.1016/j.bone.2008.08.131

Cited by 36 publications

(36 citation statements)

References 27 publications

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“…Culture carriers with defined micrometer-sized cavities ranging from single-to multicell capacity were designed to model the in vivo microenvironment with its 3D structure and different niche compartments. [9][10][11] These microcavities were functionalized with relevant molecules fibronectin (FN), heparin (HE), and collagen I fibrils (COLI) covering different suggested ''niche'' regions and functions inside the BM. [2,11] As shown previously, the specific adhesion of HSPC to immobilized HE under flow conditions affirms the idea of HE or similar glycosaminoglycans (GAGs) being localized to the BM endothelium and their involvement in the vascular niche supporting HSPC activation and migration from and to the BM.…”

Section: Introductionmentioning

confidence: 99%

Extracellular Matrix Functionalized Microcavities to Control Hematopoietic Stem and Progenitor Cell Fate

Kurth

Franke

Pompe

et al. 2011

Macromolecular Bioscience

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Polymeric microcavities functionalized with extracellular matrix components were used as an experimental in vitro model to investigate principles of hematopoietic stem and progenitor cell (HSPC) fate control. Using human CD133+ HSPC we could demonstrate distinct differences in HSPC cycling and differentiation dependence on the adhesion ligand specificity (i.e., heparin, collagen I) and cytokine levels. The presented microcavity platform provides a powerful in vitro approach to explore the role of exogenous cues in HSPC fate decisions and can therefore be instrumental to progress in stem cell biology and translational research toward new therapies.

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Section: Introductionmentioning

confidence: 99%

Extracellular Matrix Functionalized Microcavities to Control Hematopoietic Stem and Progenitor Cell Fate

Kurth

Franke

Pompe

et al. 2011

Macromolecular Bioscience

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“…"was added to standard nomenclature to indicate the influence of limited resolution andsignal-to-noise ratio [15]. In the cortical region, Ct.Th was assessed directly in 3D based on the distance transform using an algorithm adapted from the method reported by Krebs et al[17] The vertebral cortical bone has a typical thickness of around 300-400 µm [18]. Compared to QCT, partial volume effects are reduced for HR-QCT and thus HR-QCT improves, but does not eliminate, the known overestimation of thickness and underestimation of BMD in the vertebral cortical envelope.…”

mentioning

confidence: 99%

Administration of romosozumab improves vertebral trabecular and cortical bone as assessed with quantitative computed tomography and finite element analysis

Graeff

Campbell

Peña

et al. 2015

Bone

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“…For example, recently advanced imaging processing methods have been reported to quantify trabecular number accurately in in vivo images of the spine. 33 In conclusion, the extensive simulations show that a combination of texture parameters is able to quantify OA-related structural changes in the human trabecular bone network of the knee, even at spatial resolutions achievable with clinical CT equipment. Even if BMD can be obtained, additional texture measurements are essential to fully characterize changes in the trabecular bone structure, whereas BMD as a single analysis parameter is not able to fulfill this task.…”

Section: Oa-related Changes In Trabecular Bone T Lowitz Et Almentioning

confidence: 82%

Characterization of knee osteoarthritis-related changes in trabecular bone using texture parameters at various levels of spatial resolution—a simulation study

et al. 2014

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Articular cartilage and subchondral bone are the key tissues in osteoarthritis (OA). The role of the cancellous bone increasingly attracts attention in OA research. Because of its fast adaptation to changes in the loading distribution across joints, its quantification is expected to improve the diagnosis and monitoring of OA. In this study, we simulated OA progression-related changes of trabecular structure in a series of digital bone models and then characterized the potential of texture parameters and bone mineral density (BMD) as surrogate measures to quantify trabecular bone structure. Five texture parameters were studied: entropy, global and local inhomogeneity, anisotropy and variogram slope. Their dependence on OA relevant structural changes was investigated for three spatial resolutions typically used in micro computed tomography (CT; 10 lm), high-resolution peripheral quantitative CT (HR-pQCT) (90 lm) and clinical whole-body CT equipment (250 lm). At all resolutions, OA-related changes in trabecular bone architecture can be quantified using a specific (resolution dependent) combination of three texture parameters. BMD alone is inadequate for this purpose but if available reduces the required texture parameter combination to anisotropy and global inhomogeneity. The results are summarized in a comprehensive analysis guide for the detection of structural changes in OA knees. In conclusion, texture parameters can be used to characterize trabecular bone architecture even at spatial resolutions below the dimensions of a single trabecula and are essential for a detailed classification of relevant OA changes that cannot be achieved with a measurement of BMD alone.

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High resolution computed tomography of the vertebrae yields accurate information on trabecular distances if processed by 3D fuzzy segmentation approaches

Cited by 36 publications

References 27 publications

Extracellular Matrix Functionalized Microcavities to Control Hematopoietic Stem and Progenitor Cell Fate

Extracellular Matrix Functionalized Microcavities to Control Hematopoietic Stem and Progenitor Cell Fate

Administration of romosozumab improves vertebral trabecular and cortical bone as assessed with quantitative computed tomography and finite element analysis

Characterization of knee osteoarthritis-related changes in trabecular bone using texture parameters at various levels of spatial resolution—a simulation study

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