High Rates of Incident and Prevalent Anal Human Papillomavirus Infection Among Young Men Who Have Sex With Men

Glick, Sara N.; Feng, Qinghua; Popov, Viorica; Koutsky, Laura A.; Golden, Matthew R.

doi:10.1093/infdis/jit441

Cited by 68 publications

(52 citation statements)

References 24 publications

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“…In contrast to the older population in the current study, other studies of anal HPV incidence have focused on young adult MSM [17][18][19]. These studies reported incidence rates for high-risk HPV ranging from 3.1 per 100 person-years for 94 young MSM (aged 16-30 years) recruited in Seattle [17] to 76.8 per 100 person-years [18].…”

Section: Discussionmentioning

confidence: 77%

“…These studies reported incidence rates for high-risk HPV ranging from 3.1 per 100 person-years for 94 young MSM (aged 16-30 years) recruited in Seattle [17] to 76.8 per 100 person-years [18]. Among women, a study of 650 Hawaiian women with a median age of 40 years observed a 12-month incidence of high-risk anal HPV of 24% [20], which is similar to the estimate observed in the current study among MSOM (19%).…”

Section: Discussionmentioning

confidence: 99%

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Incidence, Duration, Persistence, and Factors Associated With High-risk Anal Human Papillomavirus Persistence Among HIV-negative Men Who Have Sex With Men: A Multinational Study

Nyitray¹,

Silva²,

Chang³

et al. 2016

Clin Infect Dis.

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Background. Given high rates of anal disease, we investigated the natural history of high-risk anal human papillomavirus (HPV) among a multinational group of men who have sex with men (MSM) aged 18-64 years.Methods. Anal specimens from human immunodeficiency virus-negative men from Brazil, Mexico, and the United States were genotyped. Over 2 years, 406 MSM provided evaluable specimens every 6 months for ≥2 visits. These men were stratified into men who have sex only with men (MSOM, n = 70) and men who have sex with women and men (MSWM, n = 336). Persistence was defined as ≥12 months' type-specific duration and could begin with either a prevalent or incident infection. Prevalence ratios and 95% confidence intervals were calculated by Poisson regression.Results. Median follow-up time was 2.1 years. Retention was 82%. Annual cumulative incidence of 9-valent vaccine types was 19% and 8% among MSOM and MSWM, respectively (log-rank P = .02). Duration of anal HPV did not differ for MSOM and MSWM and was a median of 6.9 months for HPV-16 after combining men from the 2 groups. Among men with prevalent high-risk infection (n = 106), a total of 36.8%, retained the infection for at least 24 months. For those with prevalent HPV-16 (n = 27), 29.6% were persistent for at least 24 months. Persistence of high-risk HPV was associated with number of male anal sex partners and inversely associated with number of female sex partners.Conclusions. MSM with prevalent high-risk HPV infection should be considered at increased risk for nontransient infection.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Incidence, Duration, Persistence, and Factors Associated With High-risk Anal Human Papillomavirus Persistence Among HIV-negative Men Who Have Sex With Men: A Multinational Study

Nyitray¹,

Silva²,

Chang³

et al. 2016

Clin Infect Dis.

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“…HPV-related infections have the potential to cause pre-cancerous lesions in the anal canal that may progress to anal cancer. Although most people will be exposed to HPV in their sexual lifetimes, certain high-risk groups including PLWH and MSM are at increased risk for developing HPV-related anal cancer (Glick et al, 2014). The current prevention options for sexually active people are limited.…”

Section: Discussionmentioning

confidence: 99%

“…The presence of HPV is nearly universal within the MSM population and, as a result, aHSIL disproportionately affects MSM who have HIV (Glick, Feng, Popov, Koutsky, & Golden, 2014;Hessol, et al, 2009;Koutsky, 1997). In a meta-analysis by Machalek et al (2012, the prevalence of aHSIL in HIV-infected MSM proved by biopsy was 29% compared with 22% in HIV-uninfected MSM.…”

Section: Hpv Epidemiologymentioning

confidence: 99%

Human Papillomavirus Biology, Pathogenesis, and Potential for Drug Discovery: A Literature Review for HIV Nurse Clinical Scientists

Walhart¹

2015

Journal of the Association of Nurses in AIDS Care

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Persistent oncogenic human papillomavirus (HPV) infection increases the probability that precancerous anal high-grade squamous intraepithelial lesions will progress to invasive anal cancer. Anal neoplasia associated with HPV disproportionately affects HIV-infected individuals, especially men who have sex with men. Prevention is limited to HPV vaccine recommendations, highlighting the need for new treatments. The purpose of this review is to provide HIV information to nurse clinical scientists about HPV-related cancer to highlight the connection between: (a) HPV biology and pathogenesis and (b) the development of drugs and novel therapeutic methods using high-throughput screening. PubMed and CINAHL were used to search the literature to determine HPV-related epidemiology, biology, and use of high-throughput screening for drug discovery. Several events in the HPV life cycle have the potential to be developed into biologic targets for drug discovery using the high-throughput screening technique, which has been successfully used to identify compounds to inhibit HPV infections.

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“…[12][13][14] Preliminary evidence has also shown that HPV may increase risk of HIV acquisition. 15 These costly and burdensome conditions are preventable, 16 yet no programs of screening for HPV infection are currently available to males.…”

mentioning

confidence: 99%

Including males in Canadian human papillomavirus vaccination programs: a policy analysis

Shapiro

Perez

Rosberger

2016

CMAJ

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High Rates of Incident and Prevalent Anal Human Papillomavirus Infection Among Young Men Who Have Sex With Men

Abstract: Although the high prevalence of HPV among YMSM highlights the desirability of vaccinating all boys as a strategy to avert the morbidity of HPV infection, most YMSM appear to remain naive to either HPV-16 or -18 well into their sexual lives and would benefit from HPV immunization.

Cited by 68 publications

References 24 publications

Incidence, Duration, Persistence, and Factors Associated With High-risk Anal Human Papillomavirus Persistence Among HIV-negative Men Who Have Sex With Men: A Multinational Study

Incidence, Duration, Persistence, and Factors Associated With High-risk Anal Human Papillomavirus Persistence Among HIV-negative Men Who Have Sex With Men: A Multinational Study

Human Papillomavirus Biology, Pathogenesis, and Potential for Drug Discovery: A Literature Review for HIV Nurse Clinical Scientists

Including males in Canadian human papillomavirus vaccination programs: a policy analysis

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