High rates of clarithromycin and levofloxacin resistance of Helicobacter pylori in patients with chronic gastritis in the south east area of Vietnam

Dang, Ngoc Quy Hue; Ha, Thi Minh Thi; Nguyen, Si-Tuan; Le, Nguyen Dang Khoa; Nguyen, Thi Minh Thi; Nguyễn, Thanh Hải; Pham, Thi Thu Hang; Tran, Van Huy

doi:10.1016/j.jgar.2020.06.007

Cited by 18 publications

(25 citation statements)

References 26 publications

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Section: Resultsmentioning

confidence: 99%

“…Meanwhile, in Singapore, a study published in 2015 revealed the primary clarithromycin resistance was 17.9% [24]. In Vietnam, the primary resistance rate of clarithromycin increased from 33% in 2008 [26] to 34.2% from 2012 to 2014 [27] and 66.1% from 2014 to 2016 [25]. a Metronidazole resistance was performed in 43 isolates while clarithromycin resistance was performed in 70 isolates; b indicates antibiotic susceptibility test was conducted directly on gastric biopsies using molecular technique without isolation of the bacteria; c 76.2% was derived from the number of isolates that harbored both mutation and wildtype variants in 23S rRNA sequence; d Total number of isolates were derived from primary and secondary isolates.…”

Section: Figurementioning

confidence: 99%

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The Emergence of Multidrug-Resistant Helicobacter pylori in Southeast Asia: A Systematic Review on the Trends and Intervention Strategies Using Antimicrobial Peptides

2021

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The emergence of multidrug-resistant H. pylori poses a public healthcare threat, particularly in low- and middle-income countries. Recently, the World Health Organization has classified clarithromycin-resistant H. pylori as high priority in the research and discovery of novel antibiotics. This study was aimed to systematically review the prevalence of primary antibiotic resistance in H. pylori in Southeast Asian countries (SEAC) and to review current studies of antimicrobial peptides against H. pylori. We systematically searched through electronic databases of studies conducted on antimicrobial resistance of H. pylori in SEA countries. Furthermore, we searched articles that conducted studies on antimicrobial peptides, naturally occurring host’s defense molecules, against H. pylori. After a series of screening processes, 15 studies were included in our systematic review. Our analysis revealed that primary resistance of H. pylori to metronidazole, clarithromycin, and levofloxacin were high in SEAC, although the primary resistance to amoxicillin and tetracycline remains low. Multidrug-resistant H. pylori are emerging in SE Asian countries. The antimicrobial peptides show promising antibacterial and antibiofilm activity against drug-resistant H. pylori. The research and discovery of antimicrobial peptides against H. pylori in SEAC will help in limiting the spread of antimicrobial resistance of H. pylori.

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Section: Resultsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

The Emergence of Multidrug-Resistant Helicobacter pylori in Southeast Asia: A Systematic Review on the Trends and Intervention Strategies Using Antimicrobial Peptides

2021

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“…In the past, it has even been proposed in the first line in areas with high clarithromycin resistance, where it demonstrated its effectiveness in more than 90% of cases [ 10 ]. However, since the use of fluoroquinolones has spread for urinary and respiratory infection, and considering that cross-resistance among fluoroquinolones may occur, a rapid rise in resistance to levofloxacin has taken place, with rates close to 40% in some reports [ 11 ]. This rise may have a relevant impact on eradication rates: a meta-analysis showed that successful eradication was achieved in 91.5% of sensitive strains and only 75% of resistant strains [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori Primary and Secondary Genotypic Resistance to Clarithromycin and Levofloxacin Detection in Stools: A 4-Year Scenario in Southern Italy

et al. 2020

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Antibiotic resistance has become an emerging problem for treating Helicobacter pylori (H. pylori) infection. Clarithromycin and levofloxacin are two key antibiotics used for its eradication. Therefore, we reviewed our experience with genotypic resistance analysis in stools to both clarithromycin and levofloxacin in the last four years to evaluate time trends, both in naive and failure patients. Patients collected a fecal sample using the THD fecal test device. Real-time polymerase chain reaction was performed to detect point mutations conferring resistance to clarithromycin (A2142C, A2142G, and A2143G in 23S rRNA) and levofloxacin (substitutions at amino acid position 87 and 91 of gyrA). One hundred and thirty-five naive patients were recruited between 2017–2020. Clarithromycin resistance was detected in 37 (27.4%). The time trend did not show any significant variation from 2017 to 2020 (p = 0.33). Primary levofloxacin resistance was found in 26 subjects (19.2%), and we observed a dramatic increase in rates from 2017 (10%) to 2018 (3.3%), 2019 (20%), and 2020 (37.8%). Ninety-one patients with at least one eradication failure were recruited. Secondary resistance to clarithromycin and levofloxacin was found in 59 (64.8%) and 45 patients (59.3%), respectively. In conclusion, our geographic area has a high risk of resistance to clarithromycin. There is also a progressive spreading of levofloxacin-resistant strains.

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“…pylori itself and cannot essentially change the host environment, which results in the high recurrence rate. Furthermore, antibiotics are prone to stimulate the gastrointestinal tract, so the abuse of antibiotics disrupts gastrointestinal bacterial homeostasis, and even causes serious antibiotic resistance and reinfection 3 . Nevertheless, current trends mean that the available treatment options for H .…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, antibiotics are prone to stimulate the gastrointestinal tract, so the abuse of antibiotics disrupts gastrointestinal bacterial homeostasis, and even causes serious antibiotic resistance and reinfection. 3 Nevertheless, current trends mean that the available treatment options for H. pylori infections will be decreased in a near future, due to increasing specific antimicrobial resistance and thus the impracticality of using antibiotics and possibly the requirement to thoroughly change the therapy regimen. Therefore, drug-discovery strategies are solicitously needed to expand current available treatment options and to counter high antimicrobial resistance rates.…”

Section: Introductionmentioning

confidence: 99%

An overview of traditional Chinese medicine therapy for Helicobacter pylori–related gastritis

Tan

2021

Helicobacter

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Background Helicobacter pylori–associated gastritis (HPAG) is a common digestive system disease that its therapeutic goal is to eradicate Helicobacter pylori. However, due to the widespread use of antibiotics, problems for example, antibiotic resistance, reinfection, and gastrointestinal side effects have emerged. The solution of above problems provides a broad space for traditional Chinese medicine (TCM) to exert its remarkable advantages on the treatment of HPAG. Methods Extensive database retrieval using platforms not limited to but including Web of Science, SpringerLink, ScienceDirect, Google Scholar, China National Knowledge Infrastructure, Wanfang, and VIP database was performed using keywords such as “Helicobacter pylori‐associated gastritis” or “HPAG” or “Helicobacter pylori” or “H. pylori” or “gastritis” and “traditional Chinese medicine” or “TCM” or “herbs” or “Chinese herbal medicine”. In addition, related books, PhD, and master's dissertations were also researched to provide a comprehensive review. Results This review mainly introduces the clinical efficacy of TCM formulas for HPAG, as well as active ingredient and pharmacological mechanisms of herbs. What's more, this review puts forward potential prospects for future research. Conclusion These research works have shown the therapeutic benefits of TCM in the treatment of HPAG. The development of TCM with more specific functions and practical data will not only become a significant trend in the world market but also have an irreplaceable role in the future treatment of HPAG. More continued researches should be undertaken in the future.

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High rates of clarithromycin and levofloxacin resistance of Helicobacter pylori in patients with chronic gastritis in the south east area of Vietnam

Cited by 18 publications

References 26 publications

The Emergence of Multidrug-Resistant Helicobacter pylori in Southeast Asia: A Systematic Review on the Trends and Intervention Strategies Using Antimicrobial Peptides

The Emergence of Multidrug-Resistant Helicobacter pylori in Southeast Asia: A Systematic Review on the Trends and Intervention Strategies Using Antimicrobial Peptides

Helicobacter pylori Primary and Secondary Genotypic Resistance to Clarithromycin and Levofloxacin Detection in Stools: A 4-Year Scenario in Southern Italy

An overview of traditional Chinese medicine therapy for Helicobacter pylori–related gastritis

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