“…Integrated optical devices based on photonic crystals (PhCs) are a promising platform for high density integration of devices which significantly enhance light-matter interaction [ 1 – 3 ]. In recent years, a wide variety of applications have been proposed and demonstrated, including optical switches [ 4 , 5 ], light emitting diodes [ 6 ], lasers [ 7 , 8 ], all-optical logic gates [ 9 , 10 ], filters [ 11 , 12 ], power splitters [ 13 , 14 ] and highly efficient modulators [ 15 – 17 ]. In particular, PhC microcavities of various architectures have attracted significant interests in molecule sensing due to their compact size, low detect limit (DL) and high sensitivity ( S ) [ 18 – 24 ], thus far, 1D PhC [ 20 , 25 , 26 ], 2D PhC [ 27 – 29 ], L3 cavities [ 30 ], slot waveguides [ 24 ], ring cavities [ 31 – 33 ], have been studied widely for sensing, since the size of PhC sensors are approximately three orders of magnitude less than commercial integrated-optic sensors [ 34 ].…”