High-protein diet associated with resistance training reduces cardiac TNF-α levels and up-regulates MMP-2 activity in rats

Nogueira, Murilo; Neto, Ivo V Sousa; Motta‐Santos, Daisy; Cantuária, Ana Paula de Castro; Lima, Stella Maris de Freitas; Rezende, Taia Maria Berto; Santana, Hugo; Petriz, Bernardo A.; Marqueti, Rita de Cássia; Almeida, Jeeser Alves de

doi:10.1080/13813455.2020.1787456

Cited by 4 publications

(4 citation statements)

References 39 publications

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“…Thus, the smallest, viable number of animals was used for the experiment. Animals were killed by intraperitoneal injection of ketamine/xylazine mix (Nogueira et al, 2020).…”

Section: Materials and Methods Ethical Approvalmentioning

confidence: 99%

“…MCC consisted of progressive climbing, with 75% of the body weight of the animal. After each set, an additional 30 g was added to the charging apparatus until the animal was unable to complete the climbing movement (Nogueira et al, 2020). The RT protocol consisted of 12 weeks of training, 3 times a week, with at least four series with progressive loads of 50%, 75%, 90% and 100% of the MCC with 2 min of interval rest between each set.…”

Section: Animals and Study Designmentioning

confidence: 99%

“…When the 100% load was reached, 30 g were added to the equipment until the rats stopped climbing the ladder. This protocol has been widely used in recent studies with RT in rodents (de Cássia Marqueti et al, 2017;Santana et al, 2019;Almeida et al, 2020;Nogueira et al, 2020).…”

Section: Animals and Study Designmentioning

confidence: 99%

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Effects of 12 weeks of resistance training on rat gut microbiota composition

Castro

Silva

Medeiros

et al. 2021

Journal of Experimental Biology

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In addition to its health benefits, exercise training has been pointed out as modulator of the gut microbiota. However, the effects of resistance training (RT) on gut microbiota composition remain unknown. Wistar rats underwent 12 weeks of RT. Body weight, glucose tolerance test, visceral body fat, triglyceride concentration, and food consumption were evaluated. The gut microbiota was analyzed by 16S rRNA gene sequencing. Rats that underwent RT showed lower body weight (p=0.0005), lower fat content (p=0.02), and better glucose kinetics (p=0.047) when compared to the control. Improvements in the diversity and composition of the gut microbiota were identified in the RT group. The relative abundance of Pseudomonas, Serratia, and Comamonas decreased significantly after 12 weeks of RT (p<0.001). These results suggest that RT has the potential to enhance the diversity of the gut microbiota and improve its biological functions.

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“…Thus, the smallest, viable number of animals was used for the experiment. Animals were killed by intraperitoneal injection of ketamine/xylazine mix (Nogueira et al, 2020).…”

Section: Materials and Methods Ethical Approvalmentioning

confidence: 99%

Section: Animals and Study Designmentioning

confidence: 99%

See 1 more Smart Citation

Effects of 12 weeks of resistance training on rat gut microbiota composition

Castro

Silva

Medeiros

et al. 2021

Journal of Experimental Biology

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“…A recent meta-analysis has shown that the effects of HPDs, such as reducing adiposity, glucose levels, and lipid profile, are insignificant [6] and suggests that long-term effects of HPDs, when not combined with RT, are still controversial. Although HPDs mitigate obesity effectively in animal studies [7,8], elsewhere some evidence suggests a possible harmful effect of high protein ingestion [9,10], with Lima et al [9] reporting that HPDs resulted in impaired blood glucose control and lipid profile parameters and enlarged liver and kidney weight in sedentary rodents. More recently, Nogueira et al [10] demonstrated that HPDs increased IL-6 levels in the left ventricle; moreover, RT was not sufficient to alleviate this pro-inflammatory response but did reduce cardiac TNF-alpha levels.…”

Section: Introductionmentioning

confidence: 99%

The Effects of High-Protein Diet and Resistance Training on Glucose Control and Inflammatory Profile of Visceral Adipose Tissue in Rats

et al. 2021

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High-protein diets (HPDs) are widely accepted as a way to stimulate muscle protein synthesis when combined with resistance training (RT). However, the effects of HPDs on adipose tissue plasticity and local inflammation are yet to be determined. This study investigated the impact of HPDs on glucose control, adipocyte size, and epididymal adipose inflammatory biomarkers in resistance-trained rats. Eighteen Wistar rats were randomly assigned to four groups: normal-protein (NPD; 17% protein total dietary intake) and HPD (26.1% protein) without RT and NPD and HPD with RT. Trained groups received RT for 12 weeks with weights secured to their tails. Glucose and insulin tolerance tests, adipocyte size, and an array of cytokines were determined. While HPD without RT induced glucose intolerance, enlarged adipocytes, and increased TNF-α, MCP-1, and IL1-β levels in epididymal adipose tissue (p < 0.05), RT diminished these deleterious effects, with the HPD + RT group displaying improved blood glucose control without inflammatory cytokine increases in epididymal adipose tissue (p < 0.05). Furthermore, RT increased glutathione expression independent of diet (p < 0.05). RT may offer protection against adipocyte hypertrophy, pro-inflammatory states, and glucose intolerance during HPDs. The results highlight the potential protective effects of RT to mitigate the maladaptive effects of HPDs.

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