High prevalence of vitamin D deficiency in children and adolescents with type 1 diabetes

Abstract

SummaryBackground: Vitamin D is important for bone health. An inadequate supply of vitamin D to the body is associated with a higher fracture risk in the elderly. Young adults with type 1 diabetes are reported to have a lower peak bone mass than healthy individuals, which could possibly lead to an increased fracture risk in the future. The prevalence of vitamin D deficiency in healthy young people is high. Thus, optimal supply of vitamin D may be of particular importance for bone health in children with type 1 diabetes.Methods: In this prospective cross-sectional study we measured serum 25-hydroxy-vitamin D, iPTH, total and ionised calcium, phosphate, and alkaline phosphatase in 129 Swiss children and adolescents with type 1 diabetes.Results: Of the 129 subjects 78 (60.5%) were vitamin D deficient, defined as a 25-hydroxy-vitamin-D level below 50 nmol/L. During the winter this number rose to 84.1%. 25-hydroxy-vitamin-D levels showed marked seasonal fluctuations, whereas there was no correlation with diabetes control. Despite the high prevalence of vitamin D deficiency, we found a low prevalence of secondary hyperparathyroidism in vitamin D deficient diabetic children and adolescents.Conclusions: Prevalence of vitamin D deficiency in diabetic children and adolescents is high. Therefore, screening for vitamin D deficiency and supplementation in children with low vitamin D levels may be considered.

Vitamin D Status in Egyptian Children and Adolescents with Type 1 Diabetes Mellitus

“…This agrees with Bin Abbas et al, and Bener et al, who found that vitamin D deficiency was considerably higher in children with T1DM (84%, 90.67% respectively) [10,11]. Although, the prevalence in this study was higher than that reported by Janner et al, 2010 and Thnc et al, 2011 (60.5%, 28% respectively) [12]. This different prevalence in vitamin D deficiency given from different countries could be related to the variability of vitamin D deficiency definition, as well as geographical environment and latitude, skin color, nutritional, social habits and may be genetic influence.…”

“…The prevalence of vitamin D deficiency in children and adolescents with T1DM is very variable among the studies [3,[10][11][12]. In the current study, 91.67% of the children and adolescents with T1DM were vitamin D deficient.…”

High prevalence of vitamin D deficiency among newly diagnosed youth-onset diabetes mellitus in north India

“…In our study 25(OH)D was significantly lower (mean ±SD of 7.88 ± 1.20 ng/mL) in patients, compared with 16.64 ± 7.83 ng/mL in the controls. Many recently published studies have found significantly lower levels of 25(OH)D in patients with diabetes compared with controls (6,8,10,26).…”

“…In the past decade, interest in diabetes mellitus and vitamin D metabolism has grown. Many epidemiological studies have found high prevalence of VDD in children with type 1 diabetes mellitus (TIDM), suggesting an association between the two (7)(8)(9)(10). Type 1 DM is an autoimmune disease with contribution from environmental insults in its causation (11).…”

High Prevalence of Vitamin D Deficiency Among Saudi Children And Adolescents With Type 1 Diabetes In Albaha Region, Saudi Arabia

“…The prevalence of vitamin D deficiency was 60.5% in a Swiss study (22), 43% in an Australian study (23), approximately 25% in an Italian study (24), and 15% in a North American study (25).…”