High Prevalence of Vitamin D Deficiency among Pregnant Women and their Newborns in an Iranian Population

Kazemi, Seyed Ali Naghi; Sharifi, Faranak; Jafari, Nahid; Mousavinasab, Seyed Nouraddin

doi:10.1089/jwh.2008.0954

Cited by 131 publications

(111 citation statements)

References 37 publications

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“…These results are consistent with other reports (30) . These data indicate that the previous reference for upper limits of ALP in pregnant women or neonates may be inappropriate.…”

Section: General Characteristicssupporting

confidence: 94%

Vitamin D status in Chinese pregnant women and their newborns in Beijing and their relationships to birth size

Song¹,

Si²,

Liu³

et al. 2012

Public Health Nutr.

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“…These results are consistent with other reports (30) . These data indicate that the previous reference for upper limits of ALP in pregnant women or neonates may be inappropriate.…”

Section: General Characteristicssupporting

confidence: 94%

Vitamin D status in Chinese pregnant women and their newborns in Beijing and their relationships to birth size

Song¹,

Si²,

Liu³

et al. 2012

Public Health Nutr.

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“…A study in black and white pregnant women residing in the northern United States found that approximately 29% of black pregnant women and 5% of white pregnant women had VDD (defined as serum 25-hydroxyvitamin D less than 37.5 nmol/L); whereas 54% of black participants and 47% of white participants had vitamin D insufficiency (defined as serum 25-hydroxyvitamin D levels 37.5 to 80 nmol/L) (Bodnar 2007). Similar results have been found in pregnant African-American adolescents (Davis 2010), pregnant Asian women (Alfaham 1995), Iranian pregnant women (Kazemi 2009), veiled or dark-skinned pregnant women (Grover 2001), Indian pregnant women (Sachan 2005), non-Western pregnant women in the Netherlands (Van der Meer 2006), and among pregnant women from Pakistan, Turkey and Somalia (Madar 2009). Recent studies in white pregnant women also show a high prevalence of VDD in the United Kingdom (Holmes 2009) andIreland (O'Riordan 2008).…”

Section: Background Description Of the Conditionsupporting

confidence: 65%

Vitamin D supplementation for women during pregnancy

Ansary¹,

Palacios²,

De-Regil³

et al. 2010

Cochrane Database of Systematic Reviews

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“…Reports from other parts of Iran have had similar results (9,10). Vitamin D deficiency is also prevalent in nonpregnant women.…”

Section: Discussionsupporting

confidence: 53%

Plasma 25-Hydroxyvitamin D and Severe Pre-Eclampsia in a Population With Profound Vitamin D Deficiency

Soveid¹,

Asadi²,

Sianati³

2016

Women's Health Bull

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Background: There is biologic and clinical evidence that links vitamin D deficiency to pre-eclampsia. The Vitamin D receptor is present in the placenta, cardiovascular system, and lymphocytes. It has anti-inflammatory, immune regulatory, and antihypertensive properties and facilitates placental implantation. Each of these processes is involved in the pathogenesis of preeclampsia. Objectives:The main purpose of this study was to study the relationship between vitamin D deficiency and severe pre-eclampsia in a population residing in southern Iran that is generally known to have a high prevalence of vitamin deficiency. As a second objective, the prevalence of vitamin D deficiency in pregnant women was investigated. Patients and Methods:We conducted a case-control study of 59 patients with severe preeclampsia and 217 controls, all of whom were from southern Iran. Cases and controls were matched for age, body mass index, and gestational age. The study was carried out in autumn and winter. Plasma 25-hydroxyvitamin D was measured using high performance liquid chromatography, and the results were compared between the two groups. Results: Almost all controls and patients had 25-hydroxyvitamin D levels below normal, and 69% had levels below 10 ng/mL. The mean 25-hydroxyvitamin D levels in the patient and control groups were 8.4 (6.2) and 8.5 (6.9) ng/ml (P = 0.80), respectively. The level of 25-hydroxyvitamin D had no significant association with subjects' body mass index or age. Conclusions: Pregnant women in our region have a high prevalence of vitamin D deficiency, and in a population with severe vitamin D deficiency, there is no significant correlation between 25-hydroxyvitamin D levels and preeclampsia. Severe deficiency masks any possible association in a case-control study. Controlled trials with vitamin D supplementation are recommended for further studies.

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High Prevalence of Vitamin D Deficiency among Pregnant Women and their Newborns in an Iranian Population

Abstract: We observed a high prevalence of physiologically significant hypovitaminosis D among pregnant women and their newborns, the magnitude of which warrants public health intervention.

Cited by 131 publications

References 37 publications

Vitamin D status in Chinese pregnant women and their newborns in Beijing and their relationships to birth size

Vitamin D status in Chinese pregnant women and their newborns in Beijing and their relationships to birth size

Vitamin D supplementation for women during pregnancy

Plasma 25-Hydroxyvitamin D and Severe Pre-Eclampsia in a Population With Profound Vitamin D Deficiency

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