High prevalence of vitamin D deficiency among children with chronic kidney disease and kidney transplant

Coccia, Paula; Blazquez, Juliana; Contreras, Maritza; Ferrais, Verónica; Raddavero, Claudia; Ghezzi, Lidia; Busaniche, Julio; Beneitez, Gonzalo; Kozak, Andrea; Ferraris, Jorge R.

doi:10.5546/aap.2017.eng.220

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…Moreover, vitamin D is vital for function of muscles through affecting on muscle metabolism (6). The main potential risk factors for vitamin D deficiency may include age more than 65 (7), obesity (8), kidney disease (9), liver disease (10) and environmental factors such as frailty, decrease outdoor physical activity and institutionalization (11). However, the effect of vitamin D deficiency on pathogenesis of various illness is controversial (12).…”

Section: Introductionmentioning

confidence: 99%

Impact of vitamin D deficiency on health with regard to kidney disease; an updated mini-review

Dorestan

Bahadoram

et al. 2018

J Nephropharmacol

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Vitamin D or cholecalciferol, as a steroidal hormone, regulates the calcium homeostasis, and bone formation with reabsorption through kidneys, parathyroid glands and bowel. There are at least 800 human genes connected with vitamin D. Previous research has confirmed the relationship between vitamin D and colorectal cancers, infections, heart diseases, multiple sclerosis (MS), bone disorders, inflammatory and autoimmune diseases, inflammatory bowel diseases, diabetes mellitus type-I and II and also progression of kidney disease. However, the relationship of vitamin D deficiency and developing of breast cancer, rheumatoid arthritis and osteoporosis is unknown. In fact, the effect of vitamin D deficiency on pathogenesis of different diseases is controversial. To cope with vitamin D deficiency, there are different recommendations such as daily intake of vitamin D supplements and more exposure to sunlight.

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Section: Introductionmentioning

confidence: 99%

Impact of vitamin D deficiency on health with regard to kidney disease; an updated mini-review

Dorestan

Bahadoram

et al. 2018

J Nephropharmacol

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Vitamin D and Secondary Hyperparathyroidism in Chronic Kidney Disease: A Critical Appraisal of the Past, Present, and the Future

Brandenburg

Ketteler

2022

Nutrients

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The association between vitamin D deficiency and especially critical shortage of active vitamin D (1,25-dihydroxyvitamin D, calcitriol) with the development of secondary hyperparathyroidism (sHPT) is a well-known fact in patients with chronic kidney disease (CKD). The association between sHPT and important clinical outcomes, such as kidney disease progression, fractures, cardiovascular events, and mortality, has turned the prevention and the control of HPT into a core issue of patients with CKD and on dialysis. However, vitamin D therapy entails the risk of unwanted side effects, such as hypercalcemia and hyperphosphatemia. This review summarizes the developments of vitamin D therapies in CKD patients of the last decades, from calcitriol substitution to extended-release calcifediol. In view of the study situation for vitamin D insufficiency and sHPT in CKD patients, we conclude that the nephrology community has to solve three core issues: (1) What is the optimal parathyroid hormone (PTH) target level for CKD and dialysis patients? (2) What is the optimal vitamin D level to support optimal PTH titration? (3) How can sHPT treatment support reduction in the occurrence of hard renal and cardiovascular events in CKD and dialysis patients?

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High prevalence of vitamin D deficiency among children with chronic kidney disease and kidney transplant

Cited by 2 publications

References 18 publications

Impact of vitamin D deficiency on health with regard to kidney disease; an updated mini-review

Impact of vitamin D deficiency on health with regard to kidney disease; an updated mini-review

Vitamin D and Secondary Hyperparathyroidism in Chronic Kidney Disease: A Critical Appraisal of the Past, Present, and the Future

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