High prevalence of thyroid carcinoma in patients with insulin resistance: a meta-analysis of case-control studies

Zhao, Jingbo; Zhang, Qianping; Yang, Yupeng; Yao, Jinming; Liao, Lin; Dong, Jianjun

doi:10.18632/aging.203529

Cited by 9 publications

(9 citation statements)

References 40 publications

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“…In addition, papillary thyroid cancer was found to be the most common histological subtype, accounting for 90% of new cases, and it has the best prognosis [ 36 ], even if most of the known risk factors for the development of thyroid cancer are family history, female sex, exposure to ionizing radiation in the head and neck, advanced age, iodine deficiency or excess, and tobacco and alcohol use. Several metabolic disorders, obesity, insulin resistance, and diabetes mellitus have recently been associated with a higher incidence of thyroid carcinoma [ 37 , 38 ]. The increasing evidence of the association of thyroid disease, including cancer, with metabolic disorders, and the different prevalence of these diseases in countries with different eating habits are attracting the attention of researchers regarding the possible preventative role of MD for the development of these diseases.…”

Section: Epidemiology Of Thyroid Diseasesmentioning

confidence: 99%

Mediterranean Diet and Thyroid: An Interesting Alliance

et al. 2022

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The Mediterranean diet, recognized as being cultural heritage by UNESCO, is mostly plant-based and includes a high consumption of whole-grain, fruit, and vegetables with a moderate consumption of alcohol during meals. Thus, it provides a small amount of saturated fatty acids and a high quantity of antioxidants and fiber. For this reason, it has been considered to have an important role in preventing cardiovascular diseases, chronic kidney diseases, type 2 diabetes mellitus, and cancer, but its relationship with thyroid function and diseases is still under debate. The aim of this review was to search for the possible correlation between the Mediterranean diet and thyroid function, and to critically evaluate the pathophysiological link between selected food intake and thyroid disorders.

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Section: Epidemiology Of Thyroid Diseasesmentioning

confidence: 99%

Mediterranean Diet and Thyroid: An Interesting Alliance

et al. 2022

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“…Hyperin-sulinemia increases cell glucose uptake and oxidative stress, and promotes thyroid cell growth, leading to hyperproliferation, carcinogenesis, and development of malignant tumors. It has been related to the thyroid nodules size in nodular disease, as well as tumoral size in patients with thyroid cancer [14,42].…”

Section: Thyroid Cancer Risk Reductionmentioning

confidence: 99%

“…In patients with hyperinsulinemia, an increased expression of tumor markers such as the proto-oncogenes: human epidermal growth factor receptor-2 (HER-2) and B-cell lymphoma-2 (Bcl2), were identified; meanwhile, tumor suppressor gene p53 was significantly decreased [10,14].…”

Section: Thyroid Cancer Risk Reductionmentioning

confidence: 99%

“…Some of the risk factors to develop thyroid cancer are exposure to ionizing radiation in the head and neck, family history, female sex, advanced age, iodine deficiency or excess, and tobacco and alcohol use. Recently, obesity, insulin resistance (IR), hyperinsulinemia, diabetes mellitus, and other metabolic disturbances have been associated with a higher incidence of thyroid carcinoma [13,14].…”

Section: Introductionmentioning

confidence: 99%

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Metformin in Differentiated Thyroid Cancer: Molecular Pathways and Its Clinical Implications

2022

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Metformin is a synthetic biguanide that improves insulin sensitivity and reduces hepatic gluconeogenesis. Aside being the first-line therapy for Type 2 Diabetes (T2D), many pleiotropic effects have been discovered in recent years, such as its capacity to reduce cancer risk and tumorigenesis. Although widely studied, the effect of metformin on thyroid cancer remains controversial. Potential mechanisms for its growth inhibitory effects have been elucidated in various preclinical studies that involved pathways related to adenosine mono-phosphate-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), mitochondrial glycerophosphate dehydrogenase (mGPDH), and the nuclear factor κB (NF-κB). Hyperinsulinemia increases cell glucose uptake and oxidative stress, and promotes thyroid cell growth, leading to hyperproliferation, carcinogenesis, and the development of malignant tumors. Furthermore, it has also been related to thyroid nodules size in nodular disease, as well as tumoral size in patients with thyroid cancer. Several clinical studies concluded that metformin might have an important role as an adjuvant therapy to reduce the growth of benign and malignant thyroid neoplasms. This suggests that metformin might be useful for patients with differentiated or poorly differentiated thyroid cancer and metabolic diseases such as insulin resistance or diabetes.

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“…Recently, the relationship between MetS and various cancers has been gradually confirmed, which can increase the mortality of cancer patients by 2.4 times [ 6 ]. IR is positively correlated with the risk of colorectal cancer [ 7 ], prostate cancer [ 8 ], endometrial cancer [ 9 ], thyroid cancer [ 10 ], breast cancer [ 11 ] and other cancers. Nevertheless, the relationship between the MetS and its components or IR and lung cancer risk is controversial or unknown.…”

Section: Introductionmentioning

confidence: 99%

Association between insulin resistance, metabolic syndrome and its components and lung cancer: a systematic review and meta-analysis

Liu,

Wang,

Tan

et al. 2024

Diabetol Metab Syndr

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Background A growing body of evidence points to the association between insulin resistance (IR), metabolic syndrome (MetS) and its components and lung cancer incidence, but remains controversial and unknown. Methods A systematic search was conducted through PubMed, Embase, Cochrane Library, the China National Knowledge Infrastructure (CNKI) and Wanfang databases for the corresponding studies. Each study reported the risk estimate and 95% confidence intervals (CI) for lung cancer, and a fixed effects model or random effects model was used for outcome. Results We included 31 publications involving 6,589,383 people with 62,246 cases of lung cancer. Diabetes mellitus (DM) (RR = 1.11, 95% CI 1.06–1.16, P = 0.000) and IR (RR = 2.35, 95% CI 1.55–3.58, P = 0.000) showed a positive association with lung cancer risk. BMI (RR = 0.66, 95% CI 0.54–0.81, P = 0.000) and HDL-C (RR = 0.88, 95% CI 0.79–0.97, P = 0.010) were negatively correlated with lung cancer. MetS(RR = 0.99, 95% CI 0.90–1.09, P = 0.801), TC (RR = 0.93, 95% CI 0.81–1.06, P = 0.274), TG (RR = 0.99, 95% CI 0.88–1.12,P = 0.884), LDL-C (RR = 1.01, 95% CI 0.87–1.16, P = 0.928), hypertension (RR = 1.01, 95% CI 0.88–1.15, P = 0.928), FBG (RR = 1.02, 95% CI 0.92–1.13, P = 0.677) and obesity (RR = 1.11, 95% CI 0.92–1.35, P = 0.280) were not associated with lung cancer. Conclusion Our study showed that the risk of lung cancer is correlated with DM, IR, BMI, and HDL-C. Timely control of these metabolic disorders may have a positive effect on preventing lung cancer. Trial registration Our study has been registered in the Prospective Register of Systematic Reviews (PROSPERO), ID: CRD42023390710.

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High prevalence of thyroid carcinoma in patients with insulin resistance: a meta-analysis of case-control studies

Cited by 9 publications

References 40 publications

Mediterranean Diet and Thyroid: An Interesting Alliance

Mediterranean Diet and Thyroid: An Interesting Alliance

Metformin in Differentiated Thyroid Cancer: Molecular Pathways and Its Clinical Implications

Association between insulin resistance, metabolic syndrome and its components and lung cancer: a systematic review and meta-analysis

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