High Prevalence of Teicoplanin Resistance among Staphylococcus epidermidis Strains in a 5-Year Retrospective Study

Teicoplanin non-susceptible coagulase-negative staphylococci in a large Australian healthcare network: Implications for treatment with vancomycin

“…Reduced susceptibility to glycopeptides has previously been most commonly seen in S. haemolyticus but this was quite rare (0.6%) in our study collection. 8,11,12 Other species which have been reported to be glycopeptide non-susceptible include S. lugdunensis, S. capitis and S. simulans. 2,4,6,13 However, none of these species were identified as Teico-NS in the current study.…”

Decreased Susceptibility to Teicoplanin and Vancomycin in Coagulase-Negative Staphylococci Isolated from Orthopedic-Device-Associated Infections

“…Several studies have reported an increase in the prevalence of CoNS with decreased susceptibility to glycopeptides (8,24). However, these studies included mainly strains from patients with CoNS bacteremia, and little information about the initial source of infection was provided.…”

“…The orthopedic surgery department of Garches hospital is a (24). These discrepancies may be explained by differences in nature of specimens, clinical context of included patients, and infectiousness of the isolated strains.…”

“…These strains usually show resistance to methicillin and most other antistaphylococcal agents (19), with the exception of the new agents tigecycline, linezolid, and daptomycin (5). Unlike that of Staphylococcus aureus (14,18), CoNS resistance to glycopeptides applies almost exclusively to teicoplanin (15,21,24). The mechanisms involved are unclear, but CoNS with decreased susceptibility to glycopeptides show cell wall thickening and tend to form cellular aggregates (7,10,15).…”

Genetic Analysis of Glycopeptide-Resistant Staphylococcus epidermidis Strains from Bone and Joint Infections

“…Recent studies report the recovery of increasing numbers of glycopeptide-resistant S. epidermidis (GRSE) strains around the world (3,4,(12)(13)(14)(15)(16). Glycopeptide resistance has been detected in a large number of S. epidermidis isolates from patients with bone and joint infections (BJIs) and is a matter of particular concern in orthopedic surgery (3).…”