Teicoplanin non-susceptible coagulase-negative staphylococci in a large Australian healthcare network: Implications for treatment with vancomycin

Wijesooriya, W.R.P.L.I.; Kotsanas, Despina; Korman, Tony M.; Graham, Maryza

doi:10.4038/sljid.v7i1.8116

Cited by 4 publications

(2 citation statements)

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“…While there was no teicoplanin resistance among the S. aureus, CoNS demonstrated an evident rise in teicoplanin resistance (8 resistant and 12 intermediate isolates), especially in S. epidermidis isolates. These results were in line with previous studies [25][26][27] where teicoplanin-resistant CoNS species were reported. Though 98% of the CoNS isolates in our study are susceptible to glycopeptides, however, the rising methicillin and glycopeptide resistance among the CoNS species is a grave concern as it limits the currently available therapeutic options to treat MDR CoNS infections.…”

Section: Discussionsupporting

confidence: 93%

The Prevalence and Antimicrobial Susceptibility Pattern of Gram-Positive Pathogens: Three-Year Study at a Tertiary Care Hospital in Mumbai, India

et al. 2021

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Introduction The growing resistance pattern of the gram-positive pathogens along with a steady increase in minimum inhibitory concentration of the currently available antibiotics have led to an increase in morbidity and mortality rates in India. This study aims to access the shifting antibiotic susceptibility paradigm of the gram-positive pathogens in various infections at a tertiary care center. Methods This is a 3-year retrospective observational study which was performed from January 2016 to December 2018 at a tertiary care hospital in Mumbai. All clinically significant gram-positive cocci isolated from a variety of clinical specimens were studied for their prevalence and antimicrobial susceptibility. Results Out of 4,428 gram-positive isolates, Staphylococcus aureus (35.3%) was the commonly encountered pathogen, followed by Enterococcus spp. (32.1%) and coagulase-negative Staphylococcus (CoNS) (25.7%). S. aureus was majorly isolated from skin and soft tissue infections (60.3%), followed by patients with respiratory tract infections (18.2%) and blood stream infections (13%). Among S. aureus, particularly methicillin-resistant S.aureus (MRSA), prevalence increased from 29.5% in 2016 to 35.1% in 2018, with an overall prevalence of 33.6%. All S. aureus isolates were 100% sensitive toward vancomycin, linezolid, tigecycline, and teicoplanin. However, the CoNS isolates showed a higher resistance rate with reduced susceptibility toward linezolid and teicoplanin. High prevalence of resistance was observed across gram-positive isolates with commonly used antibiotics such as ciprofloxacin, levofloxacin, and erythromycin. While the prevalence of linezolid-resistant enterococcus (LRE) was 3.6%, vancomycin (VRE) and teicoplanin resistance among the enterococcus species was as high as 7.7% and 7.5%, respectively. Conclusion Rising methicillin resistance among the Staphylococcal species (MRSA and MR-CoNS) along with reduced susceptibility toward currently available anti-MRSA agents is a matter of serious concern as it limits the therapeutic options for treating multidrug resistant (MDR) gram-positive infections.

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Section: Discussionsupporting

confidence: 93%

The Prevalence and Antimicrobial Susceptibility Pattern of Gram-Positive Pathogens: Three-Year Study at a Tertiary Care Hospital in Mumbai, India

et al. 2021

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“…[29] Moreover, S. aureus was sensitive to TE and resistance to CRO and C, which is not in agreement with the report published by the commission. [29] Pattern of antibiotic resistance of S. epidermidis isolated from hospital infectious specimens S. epidermidis resistance against: C, CRO, and TE were consistent with reports published by Chabi and Momtaz, [30] Wijesooriya et al, [31] and S. epidermidis sensitive to APX and NET. [32] Results show that Proteus spp.…”

Section: Discussionsupporting

confidence: 84%

The Prevalence of Microorganisms and Antibiotics Activity Tests of Natural and Industrial Products in Surgical Site Infections in Referral Hospitals in Erbil City, Kurdistan Region – Iraq

Thanoon

Mohammed

2021

Cihan U Erbil SCI J

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Background and objectives: To study the prevalence of microorganisms and antibiotics activity tests of natural and industrial products, SSIs were found in referral hospitals in Erbil, Iraq's Kurdistan province. MethodsPus samples were collected from 29 surgical patients using sterile swabs and primed for culture collection. Disc diffusion method was used to determine the bacterial activity of three types of plants (cinnamon, ginger, and radish) against three bacterial species including Staphylococcus aureus, Proteus spp., and S.epidermidis. Result: Overall 29 pus samples were processed for culture testing. One gram negative bacterium (7.14%) and thirteen gram positive cocci (92.85%) were isolated from the 14 bacteria. The three most potent isolates were found to be resistant to the variable of tested antibiotics, while they showed any sensitivity to the tested plant extracts. Cinnamon, ginger, and radish extracts were discovered to be among the few variable effective plant extracts against the tested pathogenic bacteria isolates. Conclusion: The data collected from this research showed a better way of explanation of the microorganism’s etiology of surgical site infections (SSIs) in hospitals where they might have epidemiological and healing insinuations. Keywords: Surgical Site Infections, Bacteria isolated from wounds, antimicrobial resistance, pus, plant extract.

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Evaluation of Teicoplanin Resistance Detected by Automated System in Coagulase Negative Staphylococci: A Comparison with Gradient Test and Broth Microdilution Methods

et al. 2020

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Teicoplanin non-susceptible coagulase-negative staphylococci in a large Australian healthcare network: Implications for treatment with vancomycin

Cited by 4 publications

References 12 publications

The Prevalence and Antimicrobial Susceptibility Pattern of Gram-Positive Pathogens: Three-Year Study at a Tertiary Care Hospital in Mumbai, India

The Prevalence and Antimicrobial Susceptibility Pattern of Gram-Positive Pathogens: Three-Year Study at a Tertiary Care Hospital in Mumbai, India

The Prevalence of Microorganisms and Antibiotics Activity Tests of Natural and Industrial Products in Surgical Site Infections in Referral Hospitals in Erbil City, Kurdistan Region – Iraq

Evaluation of Teicoplanin Resistance Detected by Automated System in Coagulase Negative Staphylococci: A Comparison with Gradient Test and Broth Microdilution Methods

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