High Prevalence of Skin Diseases and Need for Treatment in a Middle-Aged Population. A Northern Finland Birth Cohort 1966 Study

Sinikumpu, Suvi‐Päivikki; Huilaja, Laura; Jokelainen, Jari; Koiranen, Markku; Auvinen, Juha; Hägg, Päivi M.; Wikström, Erika; Timonen, Markku; Tasanen, Kaisa

doi:10.1371/journal.pone.0099533

Cited by 35 publications

(71 citation statements)

References 53 publications

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“…Thirdly, demonstrating that specific skin disorders are characteristic for PIDs was not possible. We could only compare the presence of a number of skin disorders in patients with a PID with the prevalence of skin disorders in the general population based on six studies varying in publication year and age of the studied population . However, most of these skin disorders were more prevalent in patients with a PID compared with the general population.…”

Section: Discussionmentioning

confidence: 99%

“…Because the reported number of patients with a PID was mainly low, the proportion of patients with a PID and skin disorders was descriptively presented. Proportions of skin disorders in PIDs were compared to the prevalence of skin disorders in the general population . Data from the general population were based on a birth cohort in Finland (n = 1932, age 45‐47 years) and a Dermatology outpatient clinic in Turkey (n = 11 040, age 1‐99 years) .…”

Section: Methodsmentioning

confidence: 99%

“…Proportions of skin disorders in PIDs were compared to the prevalence of skin disorders in the general population . Data from the general population were based on a birth cohort in Finland (n = 1932, age 45‐47 years) and a Dermatology outpatient clinic in Turkey (n = 11 040, age 1‐99 years) . In addition, a nationwide study of Furue et al reported the prevalence of cutaneous disorders in 67 448 Japanese patients of all ages.…”

Section: Methodsmentioning

confidence: 99%

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Skin disorders are prominent features in primary immunodeficiency diseases: A systematic overview of current data

Wit

Brada

Veldhuizen

et al. 2018

Allergy

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Primary immunodeficiency diseases (PIDs) are characterized by an increased risk of infections, autoimmunity, autoinflammation, malignancy, and allergic disorders. Skin disorders are also common clinical features in PIDs and may be among the presenting manifestations. Recognition of specific PID-associated skin conditions in combination with other clinical features as described in the currently used warning signs could raise suspicion of an underlying PID. We aimed to provide a systematically obtained overview of skin disorders and their prevalence in PIDs. Secondary, the prevalence of Staphylococcus (S.) aureus-associated skin disorders and atopy was reviewed, as these are the most prominent skin features in PIDs. A systematic search was performed in EMBASE, MEDLINE, Web of Science, Cochrane, and Google Scholar (up to May 9, 2018). All original observational and experimental human studies that address the presence of skin disorders in PIDs were selected. We rated study quality using the Institute of Health Economics Quality Appraisal Checklist for Case Series Studies. Sixty-seven articles (5030 patients) were included. Study quality ranged from 18.2% to 88.5%. A broad spectrum of skin disorders was reported in 30 PIDs, mostly in single studies with a low number of included patients. An overview of associated PIDs per skin disorder was generated. Data on S. aureus-associated skin disorders and atopy in PIDs were limited. In conclusion, skin disorders are prominent features in PIDs. Through clustering of PIDs per skin disorder, we provide a support tool to use in clinical practice that should raise awareness of PIDs based on presenting skin manifestations.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Skin disorders are prominent features in primary immunodeficiency diseases: A systematic overview of current data

Wit

Brada

Veldhuizen

et al. 2018

Allergy

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“…The clinical examination included a whole body skin investigation of every participant, performed by a specialist (one) in dermatology or experienced resident (two) as described (19). All skin areas were evaluated and all typical skin findings and diseases (benign and malignant skin tumors, skin infections, inflammatory skin diseases, sebaceous gland diseases, hair follicle and autoimmune skin diseases) were recorded in a pre-designed computerized database based on the International Classification of Diseases (ICD-10).…”

Section: Skin Examinationmentioning

confidence: 99%

“…All skin areas were evaluated and all typical skin findings and diseases (benign and malignant skin tumors, skin infections, inflammatory skin diseases, sebaceous gland diseases, hair follicle and autoimmune skin diseases) were recorded in a pre-designed computerized database based on the International Classification of Diseases (ICD-10). The cohort members were categorized into 4 subgroups according to their need of further interventions due to skin disease: I) Subjects with no further care needed, II) those who would recover with self-treatment, III) those to whom a general practitioner visit was recommended, and IV) cases that required further treatment by a dermatologist (19).…”

Section: Skin Examinationmentioning

confidence: 99%

The Association Between Low Grade Systemic Inflammation and Skin Diseases: A Cross-sectional Survey in the Northern Finland Birth Cohort 1966

Sinikumpu¹,

Huilaja²,

Auvinen³

et al. 2018

Acta Derm Venerol

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Low grade inflammation is associated with many noncommunicable diseases. The association between skin diseases in general and systemic inflammation has not previously been studied at the population level. A whole-body investigation on 1,930 adults belonging to Northern Finland Birth Cohort 1966 was performed and high sensitive C-reactive protein (CRP) level was measured as a marker of low grade inflammation in order to determine the association between low grade inflammation and skin diseases in an unselected adult population. After adjustment for confounding factors the following skin disorders were associated with low grade inflammation in multinomial logistic regression analysis: atopic eczema (OR 2.2, 95% CI 1.2-3.9), onychomycosis (OR 2.0, 1.2-3.2) and rosacea (OR 1.7, 1.1-2.5). After additionally adjusting for body mass index and systemic diseases, the risks for atopic eczema (OR 2.4, 1.3-4.6) and onychomycosis (OR 1.9, 1.1-3.1) remained statistically significant. In conclusion, low grade inflammation is present in several skin diseases.

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Assessment of Frequency of Rosacea Subtypes in Patients With Rosacea

et al. 2022

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IMPORTANCEFour distinct rosacea subtypes have traditionally been recognized, but the frequency of these subtypes among patients with rosacea remains unknown.OBJECTIVE To assess the frequency of 4 rosacea subtypes.DATA SOURCES This systemic review and meta-analysis included a search of 2 databases, PubMed and Embase, from inception of the databases to November 2, 2021. The search was filtered to include only studies of human participants published in English, French, and German.STUDY SELECTION Studies were screened independently by 2 of the authors and were included if they were original with a sample size of 25 or more patients and reported absolute numbers or frequency of patients affected by rosacea subtypes. Studies that did not report sufficient data to calculate the proportions of subtypes were excluded. DATA EXTRACTION AND SYNTHESISData extraction was performed independently and in duplicate by 2 of the authors, using the search term rosacea, according to the Preferred Reporting items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The search term, objectives, and study protocol methods were defined before the study was initiated. A total of 292 studies were included for full-text assessment. Owing to the heterogeneity of the included studies, a random-effects model was used. MAIN OUTCOME AND MEASURESThe main outcome was the proportion of patients with rosacea in each of the 4 major subtype groups defined by the 2002 National Rosacea Society classification system. Measures were absolute numbers or frequency of patients affected by each of the 4 rosacea subtypes.RESULTS A total of 39 studies examining 9190 patients with rosacea were included. The pooled proportion of erythematotelangiectatic rosacea was 56.7% (95% CI, 51.4%-62.0%), of papulopustular rosacea was 43.2% (95% CI, 38.8%-47.6%), of phymatous rosacea was 7.4% (95% CI, 6.1%-8.9%), and of ocular rosacea was 11.1% (95% CI, 6.7%-16.3%). Subtype distribution occurred equally among men and women except for phymatous rosacea, which was more prevalent in men. Studies from Africa showed the lowest proportion of erythematotelangiectatic rosacea. Differences in frequency of subtypes were observed when stratification by publication year was performed. CONCLUSION AND RELEVANCEIn this systematic review and meta-analysis, differences were found in rosacea subtypes by patient sex and by continent of origin and publication year of included studies. Erythematotelangiectatic and papulopustular rosacea were the most prevalent subtypes, but data should be interpreted with caution. Future studies should use the phenotype-based rosacea approach.

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High Prevalence of Skin Diseases and Need for Treatment in a Middle-Aged Population. A Northern Finland Birth Cohort 1966 Study

Cited by 35 publications

References 53 publications

Skin disorders are prominent features in primary immunodeficiency diseases: A systematic overview of current data

Skin disorders are prominent features in primary immunodeficiency diseases: A systematic overview of current data

The Association Between Low Grade Systemic Inflammation and Skin Diseases: A Cross-sectional Survey in the Northern Finland Birth Cohort 1966

Assessment of Frequency of Rosacea Subtypes in Patients With Rosacea

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