The Association Between Low Grade Systemic Inflammation and Skin Diseases: A Cross-sectional Survey in the Northern Finland Birth Cohort 1966

Sinikumpu, Suvi‐Päivikki; Huilaja, Laura; Auvinen, Juha; Jokelainen, Jari; Puukka, Katri; Ruokonen, Aimo; Timonen, Markku; Tasanen, Kaisa

doi:10.2340/00015555-2795

Cited by 30 publications

(28 citation statements)

References 27 publications

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“…Both clinical and experimental studies have confirmed the important role of inflammation in the pathogenesis of rosacea [ 31 ]. A cross-sectional study found that hs-CRP was higher in patients with rosacea than in those with no skin disease ( p = 0.001) [ 32 ]. All these indicate that, in analogy to psoriasis [ 33 ], the low-grade inflammation in rosacea might be systemic.…”

Section: Discussionmentioning

confidence: 99%

[Retracted] Association between Rosacea and Cardiovascular Diseases and Related Risk Factors: A Systematic Review and Meta‐Analysis

Guo

Hao

et al. 2020

BioMed Research International

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Background. Rosacea is a common inflammatory skin disorder. Several studies, but not all, have suggested a high prevalence of cardiovascular diseases (CVDs) in rosacea patients. This study is aimed at investigating the association between rosacea and CVDs and related risk factors. Methods. We performed a literature search through PubMed, Embase, and Web of Science databases, from their respective inception to December 21, 2019. Two reviewers independently screened the articles, extracted data, and performed analysis, following the PRISMA guidelines. Odds ratios (OR) or standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated for outcomes. The included studies’ quality was evaluated using the Newcastle Ottawa Scale (NOS). Results. The final meta-analysis included ten studies. The pooled analysis found no association between rosacea prevalence and the incidence of CVDs (OR 0.97; 95% CI 0.86-1.10). Rosacea was found to be significantly associated with several risk factors for CVDs (OR 1.17; 95% CI 1.05-1.31), including hypertension (OR 1.17; 95% CI 1.02-1.35), dyslipidemia (OR 1.34; 95% CI 1.00-1.79), and metabolic syndrome (OR 1.72; 95% CI 1.09-2.72). However, no association was found between rosacea and diabetes mellitus (OR 0.98; 95% CI 0.82-1.16). Among the biological parameters, a significant association was found between rosacea and total cholesterol (SMD=0.40; 95% CI=−0.00, 0.81; p<0.05), low-density lipoprotein cholesterol (SMD=0.28; 95% CI=0.01, 0.56; p<0.05), and C-reactive protein (CRP) (SMD=0.25; 95% CI=0.10, 0.41; p<0.05). We found no association between rosacea and high-density lipoprotein cholesterol (SMD=0.00; 95% CI=−0.18, 0.18; p=0.968) or triglycerides (SMD=0.10; 95% CI=−0.04, 0.24; p=0.171). Conclusions. Although no significant association was found between rosacea and CVDs, rosacea was found to be associated with several of related risk factors. Patients with rosacea should pay more attention to identifiable CVD risk factors, especially those related to inflammatory and metabolic disorders.

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Section: Discussionmentioning

confidence: 99%

[Retracted] Association between Rosacea and Cardiovascular Diseases and Related Risk Factors: A Systematic Review and Meta‐Analysis

Guo

Hao

et al. 2020

BioMed Research International

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“…Some cases of onychomycosis are associated with paronychia, a periungual inflammation [15,16]. Moreover, some studies suggested that low grade systemic inflammation may be associated with onychomycosis as well [17]. The inflammatory response involves an oxidative stress as an injury mechanism [18].…”

Section: Introductionmentioning

confidence: 99%

Allium sativum Extract Chemical Composition, Antioxidant Activity and Antifungal Effect against Meyerozyma guilliermondii and Rhodotorula mucilaginosa Causing Onychomycosis

et al. 2019

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Onychomycosis is a major health problem due to its chronicity and resistance to therapy. Because some cases associate paronychia, any therapy must target the fungus and the inflammation. Medicinal plants represent an alternative for onychomycosis control. In the present work the antifungal and antioxidant activities of Alium sativum extract against Meyerozyma guilliermondii (Wick.) Kurtzman & M. Suzuki and Rhodotorula mucilaginosa (A. Jörg.) F.C. Harrison, isolated for the first time from a toenail onychomycosis case, were investigated. The fungal species were confirmed by DNA molecular analysis. A. sativum minimum inhibitory concentration (MIC) and ultrastructural effects were examined. At the MIC concentration (120 mg/mL) the micrographs indicated severe structural alterations with cell death. The antioxidant properties of the A. sativum extract were evaluated is a rat turpentine oil induced inflammation, and compared to an anti-inflammatory drug, diclofenac, and the main compound from the extract, allicin. A. sativum reduced serum total oxidative status, malondialdehyde and nitric oxide production, and increased total thiols. The effects were comparable to those of allicin and diclofenac. In conclusion, the garlic extract had antifungal effects against M. guilliermondii and R. mucilaginosa, and antioxidant effect in turpentine-induced inflammation. Together, the antifungal and antioxidant activities support that A. sativum is a potential alternative treatment in onychomycosis.

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“…factors, 3,8 gluco-metabolic disturbances including insulin resistance related to systemic low-grade inflammation in patients with AD, 9,10 and possibly use of topical and systemic corticosteroids. 11 Systemic low-grade inflammation (determined by circulating inflammatory markers), as observed in some patients with AD, is a risk factor for insulin resistance and the development of type 2 diabetes.…”

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confidence: 99%

Normal insulin sensitivity, glucose tolerance, gut incretin and pancreatic hormone responses in adults with atopic dermatitis

Gether

Thyssen

Gyldenløve

et al. 2020

Diabetes Obesity Metabolism

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Aim: To examine whether adults with mild to moderate atopic dermatitis (AD) had reduced insulin sensitivity and/or exhibited other gluco-metabolic disturbances compared with carefully matched healthy controls. Materials and methods: Sixteen adult, non-obese, non-diabetic patients with mild to moderate AD and 16 gender-, age-and body mass index (BMI)-matched healthy controls underwent a hyperinsulinaemic euglycaemic clamp (insulin infusion rate: 40 mU/m 2 /minute) and an oral glucose tolerance test (OGTT) with frequent blood sampling for gut and pancreatic hormones. Results: The two groups were similar in age (33 ± 3 vs. 33 ± 3 years, mean ± standard error of the mean [SEM]), gender (56% women), BMI (24.5 ± 0.7 vs. 24.4 ± 0.7 kg/m 2), physical activity level, fasting plasma glucose and HbA1c. Patients with AD had a mean Eczema Area and Severity Index score of 8.5 ± 1.0 (moderate disease) and a mean AD duration of 28 ± 3 years. During the OGTT, circulating glucose, insulin, C-peptide, glucagon and glucose-dependent insulinotropic polypeptide, respectively, were similar in the two groups, except glucagon-like peptide-1, which was higher in patients with AD. The clamp showed no differences in insulin sensitivity between groups (M-value 9.2 ± 0.6 vs. 9.8 ± 0.8, P = .541, 95% CI −1.51; 2.60), or circulating insulin, C-peptide and glucagon levels. Conclusions: Using OGTT and the hyperinsulinaemic euglycaemic clamp technique, we found no difference in insulin sensitivity or other gluco-metabolic characteristics between patients with mild to moderate AD and matched healthy controls, suggesting that the inflammatory skin disease AD has little or no influence on glucose metabolism. K E Y W O R D S clinical physiology, clinical trial, insulin resistance 1 | INTRODUCTION Atopic dermatitis (AD) is a common chronic and recurrent itchy inflammatory skin condition characterized by dry skin and eczema typically located at flexural sites (e.g. elbows and knees). 1,2 Epidemiological studies have shown an increased occurrence of type 2 diabetes in adults with AD. 3,4 This association may be explained by overweight and obesity, 5,6 reduced physical activity, 7 shared genetic risk

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The Association Between Low Grade Systemic Inflammation and Skin Diseases: A Cross-sectional Survey in the Northern Finland Birth Cohort 1966

Cited by 30 publications

References 27 publications

[Retracted] Association between Rosacea and Cardiovascular Diseases and Related Risk Factors: A Systematic Review and Meta‐Analysis

[Retracted] Association between Rosacea and Cardiovascular Diseases and Related Risk Factors: A Systematic Review and Meta‐Analysis

Allium sativum Extract Chemical Composition, Antioxidant Activity and Antifungal Effect against Meyerozyma guilliermondii and Rhodotorula mucilaginosa Causing Onychomycosis

Normal insulin sensitivity, glucose tolerance, gut incretin and pancreatic hormone responses in adults with atopic dermatitis

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