High Prevalence of Silent Gallstone Disease in Dialysis Patients

Badalamenti, Salvatore; Defazio, Cristina; Castelnovo, Claudia; Sangiovanni, A.; Como, Giovanna; Vecchi, A. De; Graziani, G.; Colombo, Massimo; Ponticelli, Claudio

doi:10.1159/000187805

Cited by 35 publications

(30 citation statements)

References 6 publications

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“…Table 1 shows the relevant data of our study in comparison to those of Gladziwa et al [5] and Badalementi et al [6]. Of note, the former included only HD patients.…”

Section: Resultsmentioning

confidence: 96%

“…Diabetic nephropathy as the cause of their end-stage renal disease was present in 6.9 and 1.7% of the patients studied by Gladziwa et al [5] and Badalementi et al [6], respectively, whilst they were excluded from our study. The prevalence of CL in comparison to a local healthy population in the study performed by Gladziwa et al [5] was 20.9 versus 29.3% (p = NS) and in the study by Badalementi et al [6] 27.8 versus 8–11% (p < 0.01).…”

Section: Resultsmentioning

confidence: 99%

“…Whether this increased biliary lithogenicity is clinically translated into an increased prevalence of GS in dialyzed patients remains an open question. Only two previous studies [5, 6] have addressed this subject with, however, contradictory results. Whereas Gladziwa et al [5] found a similar prevalence of GS in HD patients as compared with a local general population, Badalementi et al [6], studying both HD and continuous ambulatory peritoneal dialysis (CAPD) patients, reported a higher prevalence.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Cholelithiasis in Non-Diabetic Haemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

Korzets

Golan

Ben-Chitrit

et al. 1997

Nephron

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Haemodialyzed (HD) patients have been found to have an increased bile cholesterol level and an increased saturation index in bile. These changes were markedly enhanced in the presence of a low-protein diet. To evaluate whether such changes influence the prevalence of cholelithiasis in patients with end-stage renal failure, real-time sonography was performed to detect the presence of gallstones (GS) in 54 HD (28 males, 26 females, mean age 52.4 ± 15.4 years) and 39 continuous ambulatory peritoneal dialysis (CAPD; 22 males, 17 females, mean age 59.1 ± 14.9 years) patients. No patient had diabetes. The patients’ charts were reviewed for the following data: age, sex, primary renal disease, obesity (20% above ideal weight), history suggestive of gallbladder disease or previous cholecystectomy, duration of dialysis, and serum cholesterol levels. Overall, cholelithiasis was documented in 12 of 93 (12.9%) patients, 7 HD and 5 CAPD. When comparing the factors outlined above, no significant difference was found between HD and CAPD patient groups, either with or without cholelithiasis. Gallbladder disease was asymptomatic in all except 1 patient who required cholecystectomy. Using a healthy control group consisting of local age- and sex-matched inhabitants, GS were found in 8 of 134 (6%) of them (p > 0.05). We conclude that the prevalence rate of GS in our dialysis population (HD and CAPD) is similar to that of a local general population following a western-style diet, irrespective of dialysis mode.

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“…Table 1 shows the relevant data of our study in comparison to those of Gladziwa et al [5] and Badalementi et al [6]. Of note, the former included only HD patients.…”

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Cholelithiasis in Non-Diabetic Haemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

Korzets

Golan

Ben-Chitrit

et al. 1997

Nephron

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“…69 Interestingly, the risk of gallstone formation is higher in patients before dialysis but not those undergoing chronic hemodialysis therapy, and in patients with renal transplant than those without transplant. 18,19 However, Badalamenti et al 70 reported the presence of gallstone in 28% of 119 patients on regular dialysis treatment and no relationships were found between gallstones and age or modes of dialysis. Therefore, screening for renal stone and gallstone disease during renal disease may allow early diagnosis and management.…”

Section: Relevance Of Renal and Gallstones In Renal Failurementioning

confidence: 99%

The association between renal stone disease and cholesterol gallstones: the easy to believe and not hard to retrieve theory of the metabolic syndrome

2014

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(2014) The association between renal stone disease and cholesterol gallstones: the easy to believe and not hard to retrieve theory of the metabolic syndrome, Renal Failure, 36:6,[957][958][959][960][961][962] AbstractRenal stone disease and gallstone disease are widely prevalent and costly disease across the globe. Both renal stone disease and gallstone disease are associated with a variety of diseases including obesity, metabolic syndrome, dyslipidemia, hypertension, insulin resistance diabetes and gout. Importantly, the presence of either renal stone disease or gallstone disease is associated with an increased risk of cardiovascular disease. In a recent study of the Atherosclerosis Risk in Communities (ARIC), individuals with a history of gallstones were 54% more likely to report a history of nephrolithiasis after adjusting for age, gender, body size and other factors. Furthermore, in three large cohorts including over 240,000 subjects: the Nurses' Health Studies (NHS) I and II and the Health Professionals Follow-up Study (HPFS), showed that gallstone disease is independently associated with nephrolithiasis. The mechanisms linking gallstone disease and renal stone disease are complex and not yet established. Insulin resistance, lithogenic diets, alterations of transporters in gallbladder and urinary system, and pH are possible potential mechanisms for future exploration. How the liver communicates with kidney in individuals with renal stone disease and gallstone disease is not well known and whether this communication is similar as in hepto-renal syndrome is subject for future research. Further research is needed to determine: (i) the underlying mechanisms of renal stone disease and gallstone disease; (ii) the potential treatment of renal stone disease and gallstone disease.

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“…Dear Sir, We read with great interest the short com munication by Badalamcnti et al [1], who found a higher prevalence o f gallstone dis ease in patients on regular dialysis treatment (33 of 119; 28%) than in the general Italian population (8-11%). Twenty-nine had gall stones and 4 had had previous cholecystecto mies for colicky gallstones.…”

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confidence: 99%

Gallstone Disease in Dialysis Patients

Gladziwa¹

1995

Nephron

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High Prevalence of Silent Gallstone Disease in Dialysis Patients

Cited by 35 publications

References 6 publications

Prevalence of Cholelithiasis in Non-Diabetic Haemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

Prevalence of Cholelithiasis in Non-Diabetic Haemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

The association between renal stone disease and cholesterol gallstones: the easy to believe and not hard to retrieve theory of the metabolic syndrome

Gallstone Disease in Dialysis Patients

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