High Prevalence of Polycystic Ovary Syndrome in Type 1 Diabetes Mellitus Adolescents: Is There a Difference Depending on the NIH and Rotterdam Criteria?

Busiah, Kanetee; Colmenares, Ana; Bidet, Maud; Tubiana‐Rufi, N.; Lévy-Marchal, Claire; Delcroix, Christine; Jacquin, Paul; Martin, Delphine; Benadjaoud, Lila; Jacqz-Aigrain, Évelyne; Laborde, Kathleen; Robert, Jean‐Jacques; Samara-Boustani, Dinane; Polak, Michel

doi:10.1159/000471805

Cited by 21 publications

(17 citation statements)

References 42 publications

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“…PCOS incidence is higher in T1DM women than in the general population (Escobar-Morreale & Roldán-Martín 2016). Adolescent girls with T1DM also displayed a greater prevalence of PCOS (Busiah et al 2017). Insulin therapy in T1DM may result in hyperinsulinemia that can aggravate PCOS through hyperandrogenism (Shigiyama et al 2016).…”

Section: Differences Between Tidm and Endo Links With Polycystic Ovarmentioning

confidence: 99%

Co-morbidity of type 1 diabetes and endometriosis: bringing a new paradigm into focus

Simmen

Brown

Quick

et al. 2019

Journal of Endocrinology

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Type 1 diabetes mellitus and endometriosis separately affect millions of women worldwide. Reproductive-age women diagnosed with type 1 diabetes may also suffer from endometriosis, but the asymptomatic pre-clinical period of highly variable duration for each condition can lead to challenges in the timely recognition of co-morbid disease onset and misdiagnosis. While knowledge of the pathogenesis of each condition has grown substantially, co-morbid endometriosis and type 1 diabetes has not been widely considered and much less addressed. This review discusses the molecular rationale for the likelihood of their co-existence, and prospects for improvements in therapeutic strategies and reduced complications, if this paradigm is included as a significant variable in disease management.

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Section: Differences Between Tidm and Endo Links With Polycystic Ovarmentioning

confidence: 99%

Co-morbidity of type 1 diabetes and endometriosis: bringing a new paradigm into focus

Simmen

Brown

Quick

et al. 2019

Journal of Endocrinology

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“…Recently, the French authors have presented results of the study conducted on 53 adolescent girls [41]. These authors found a high incidence of PCOS in adolescent girls with type 1 diabetes mellitus.…”

Section: Insulin Resistance In Pcosmentioning

confidence: 99%

Polycystic ovary syndrome (PCOS) and the accompanying disorders of glucose homeostasis among girls at the time of puberty

Otto-Buczkowska

Grzyb

Jainta

2018

Pediatr Endocrino Diabetes Metab

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Polycystic ovary syndrome (PCOS) usually arises during puberty and is marked by insulin resistance, hyperinsulinemia, and hyperandrogenism. The principle is that the diagnosis of PCOS must be based on the presence of at least two of the following three criteria: chronic anovulation, hyperandrogenism (clinical or biological), and polycystic ovaries. The diagnosis of PCOS in adolescents is particularly difficult due to developmental problems in this group. Many symptoms of PCOS, including acne, menstrual irregularities, and hyperinsulinemia, are common in normal puberty. Adolescents with PCOS are at an increased risk of developing health problems later on in life, such as diabetes, cardiovascular disease, and infertility. One should reckon with the frequent occurrence of the PCOS in type 1 diabetes, when the ovaries and the adrenals are exposed to excessive insulin concentrations. Ovarian hyperandrogenism is common in adolescent girls with type 1 diabetes. Methods of treatment for an adolescent with PCOS include diet and exercise. Metformin is commonly used in young girls and adolescents with PCOS as first-line monotherapy or in combination with anti-androgen medications. StreszczenieZespół policystycznych jajników (PCOS) zwykle pojawia się w okresie dojrzewania i charakteryzuje się występowaniem insulinooporności, hiperinsulinemii i hiperandrogenizmu. Przyjęta jest zasada, że diagnoza PCOS musi opierać się na obecności co najmniej dwóch z trzech następujących kryteriów: przewlekłego braku owulacji, hiperandrogenizmu (klinicznego lub biologicznego) i policystycznych jajników. Rozpoznanie PCOS u nastolatek jest szczególnie trudne. Wiele objawów PCOS, w tym trądzik, zaburzenia miesiączkowania i hiperinsulinemia, są częste w okresie dojrzewania. U nastolatek z PCOS istnieje zwiększone ryzyko wystąpienia problemów zdrowotnych w późniejszym życiu, takich jak cukrzyca, choroby sercowo-naczyniowe i niepłodność. Należy liczyć się z częstym występowaniem PCOS w cukrzycy typu 1, gdy jajniki i nadnercza są narażone na nadmierne stężenia insuliny. Hiperandrogenizm pochodzenia jajnikowego występuje często u nastolatek z cukrzycą typu 1. Leczenie młodzieży z PCOS obejmuje dietę i ćwiczenia fizyczne. Metformina jest powszechnie stosowana u młodych dziewcząt z PCOS w monoterapii pierwszego rzutu lub w połączeniu z lekami przeciwandrogenowymi. Słowa kluczowe hiperandrogenizm, zespół policystycznych jajników, insulinooporność, cukrzyca

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“…Polycystic ovarian syndrome (PCOS) is an endocrine syndrome characterized by persistent anovulation, hyperandrogenemia or insulin resistance, and is the most common cause of infertility in women of childbearing age [1]. In recent years, PCOS has been de ned as a metabolic syndrome because it is often accompanied by metabolic disorders such as obesity, insulin resistance, hyperlipidemia, and long-term risk of type 2 diabetes, hypertension, and other cardiovascular diseases, seriously affecting the physical and mental health of women of childbearing age [2,3]. At present, the treatment for insulin resistance in PCOS patients is mainly to increase insulin sensitivity in peripheral tissues, and the representative drug is metformin.…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology-based Strategy for Predicting Active Ingredients and Potential Targets of Coptis Chinensis Franch in Polycystic Ovary Syndrome

et al. 2020

Preprint

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Background: Polycystic ovary syndrome (PCOS) is a disease that causes low fertility in females. Coptis chinensis (CC) has been used to clear away heat and dampness, purify fire, and detoxify in traditional Chinese medicine (TCM). Although CC has demonstrated efficacy against PCOS in clinical practice, there is no available data regarding the bioactive ingredients, component targets, and confirmed molecular mechanism of this drug combination.Methods: A network pharmacology approach was applied to analyze the bioactive ingredients, component targets, and core signaling pathways of CC. The TCM systems pharmacology database and analysis platform (TCMSP) was used to screen effective active ingredients and targets of CC. The GeneCards, OMIM, and PharmGkb databases was utilized to screen disease targets for PCOS. R language software was used to screen common targets of drugs and diseases. Cytoscape software (version 3.7.1) was utilized to build a drug-active ingredient-disease target interaction network, and the STRING platform was utilized to construct a common target protein-protein interaction network, including 102 nodes and 221 edges. OmicShare tools was used to analysis Gene ontology (GO) biological function analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) path enrichment. Schrodinger software was used to evaluate the interaction between active components and their targets and explore binding modes.Results: 14 effective active ingredients and 218 targets of CC were screened by TCMSP platform. 3517 disease targets for PCOS were obtianed by the disease database and 102 common targets of drugs and diseases were screened through R language software. Key targets of CC for the treatment of PCOS included JUN, MAPK, IL-6, CXCL8, FOS, and IL1B. A total of 123 Gene Ontology (GO) terms and 129 pathways were acquired by analyzing the enrichment of GO and KEGG. It is speculated that the AGEs/RAGE, TNF, IL-17, MAPK and HIF-1 signaling pathways are closely related to PCOS and may be the core pathways involved in PCOS. The molecular docking results showed that quercetin has a higher degree of binding to core targets (eg: IL-6, IL- 1β, MAPK, CXCL8) related to the inflammatory pathway.Conclusions: This preliminary study verified the basic pharmacological effects and mechanisms of CC, a Chinese medicine, in the treatment of PCOS. Particularly, the effect of CC on inflammation and glucose metabolism pathway was noteworthy. This study provides new insights for the systematic exploration of the mechanism of action of Chinese medicine.

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High Prevalence of Polycystic Ovary Syndrome in Type 1 Diabetes Mellitus Adolescents: Is There a Difference Depending on the NIH and Rotterdam Criteria?

Cited by 21 publications

References 42 publications

Co-morbidity of type 1 diabetes and endometriosis: bringing a new paradigm into focus

Co-morbidity of type 1 diabetes and endometriosis: bringing a new paradigm into focus

Polycystic ovary syndrome (PCOS) and the accompanying disorders of glucose homeostasis among girls at the time of puberty

Network Pharmacology-based Strategy for Predicting Active Ingredients and Potential Targets of Coptis Chinensis Franch in Polycystic Ovary Syndrome

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