High prevalence of metabolic syndrome in an elderly Croatian population – a multicentre study

Introduction:Metabolic syndrome (MetS) is a multifactorial disorder in which dyslipidemia plays an important role. Fatty acid-binding protein 2 (FABP 2) is responsible for transport of free fatty acids in the intestinal endothelium cells. FABP2-genetic variants might affect plasma lipid concentrations and intracellular lipid transport. The aim of this study was to investigate the association between FABP2 Ala54Thr genetic polymorphism and metabolic syndrome and some biochemical and anthropological parameters in elderly subjects.Materials and methods:This cross-sectional study included 140 men and 176 women older than 70 years. Fasting serum concentration of glucose, lipid parameters, total proteins and C-reactive protein were determined by standardized methods. Presence (MetS(+)) or absence (MetS(−)) of MetS was determined according to criteria of the International Diabetes Federation. FABP2 genetic polymorphism Ala54Thr (rs1799883) was genotyped with PCR-RFPL.Results:The genotype frequencies for Ala/Ala, Ala/Thr and Thr/Thr genotype were 60, 36 and 6 in MetS(−), and 131, 70 and 13 in MetS(+), respectively, without statistical significance (P = 0.567). Ala/Ala genotype was a subgroup of non-carriers, while Ala/Thr and Thr/Thr genotypes were Thr54-carriers. Median triglyceride concentration was significantly lower in carriers then in non-carriers for whole MetS(+) group (P = 0.050); there were no significant difference between men with MetS (P = 0.144), but there was a difference between women with MetS (P = 0.020). T-test showed that mean HDL cholesterol concentrations in MetS(+) group for Thr54-carriers was significantly higher in whole group (P = 0.001), and for both genders (men P = 0.039; women P = 0.004) as compared to non-carriers.Conclusions:FABP2 genetic polymorphism is associated with lower triglyceride and higher HDL-cholesterol concentrations in elderly subjects with MetS. This genetic variation might be a useful marker for understanding dyslipidemia in MetS.

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“…Study design was already described in details elsewhere (22,23). In short, the cohort was established in 1969, with 3 follow-ups.…”

Section: Methodsmentioning

confidence: 99%

FABP 2 gene polymorphism and metabolic syndrome in elderly people of Croatian descent

et al. 2012

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“…Lifestyle interventions are the primary strategy in MetS therapy today, and fish consumption could be useful in dietary strategies to improve MetS components. To our knowledge, few studies have investigated associations between fish consumption and MetS [16] and the published results are not conclusive [17,18,19,20,21,22,23,24,25]. …”

Section: Introductionmentioning

confidence: 99%

Lean Fish Consumption Is Associated with Beneficial Changes in the Metabolic Syndrome Components: A 13-Year Follow-Up Study from the Norwegian Tromsø Study

2017

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Background: Fish consumption may have beneficial effects on metabolic syndrome (MetS); however, limited information of such associations exists. This study investigated possible associations between fish consumption and changes in MetS components during a 13-year follow-up period. Methods: The sample included participants (26–69 years) from the Tromsø Study 4 (1994–1995, n = 23,907) and Tromsø Study 6 (2007–2008, n = 12,981). Data were collected using questionnaires including food frequency questions, non-fasting blood samples, and physical examinations. MetS was defined using the Joint Interim Societies (JIS) definition, in which one point was given for each MetS criteria fulfilled (metabolic score). Longitudinal analyses were performed using Linear mixed models. Results: For both genders, lean fish consumption once a week or more was significantly associated with decreased future metabolic score, decreased triglycerides, and increased high-density lipoprotein (HDL)-cholesterol, whereas decreased waist circumference and blood pressure was identified only for men (age adjusted models). Fatty fish consumption was significantly associated with increased waist circumference for both genders and increased HDL-cholesterol levels in men. Conclusion: The results suggest that fatty and lean fish consumption may influence MetS differently and that lean fish consumption in particular seems to be associated with beneficial changes in the MetS components.

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“…The criteria for diagnosing MetS for the included studies are shown in Table 1, and study characteristics are provided in Table 2. The included studies comprise of one intervention study from Iceland [10], one follow-up study from Korea [11], and five cross-sectional studies [12][13][14][15][16]-three conducted in Europe (Finland [12], Croatia [14], France [15]), one in USA [13], and one in Iran [16].…”

Section: Resultsmentioning

confidence: 99%

Prevalence of metabolic syndrome in Qazvin Metabolic Diseases Study (QMDS), Iran: A comparative analysis of six definitions

Esmailzadehha¹,

Ziaee²,

Kazemifar³

et al. 2013

endo

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High prevalence of metabolic syndrome in an elderly Croatian population – a multicentre study

Cited by 13 publications

References 45 publications

FABP 2 gene polymorphism and metabolic syndrome in elderly people of Croatian descent

FABP 2 gene polymorphism and metabolic syndrome in elderly people of Croatian descent

Lean Fish Consumption Is Associated with Beneficial Changes in the Metabolic Syndrome Components: A 13-Year Follow-Up Study from the Norwegian Tromsø Study

Prevalence of metabolic syndrome in Qazvin Metabolic Diseases Study (QMDS), Iran: A comparative analysis of six definitions

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