FABP 2 gene polymorphism and metabolic syndrome in elderly people of Croatian descent

Abstract

Introduction:Metabolic syndrome (MetS) is a multifactorial disorder in which dyslipidemia plays an important role. Fatty acid-binding protein 2 (FABP 2) is responsible for transport of free fatty acids in the intestinal endothelium cells. FABP2-genetic variants might affect plasma lipid concentrations and intracellular lipid transport. The aim of this study was to investigate the association between FABP2 Ala54Thr genetic polymorphism and metabolic syndrome and some biochemical and anthropological parameters in elderly subjects.Materials and methods:This cross-sectional study included 140 men and 176 women older than 70 years. Fasting serum concentration of glucose, lipid parameters, total proteins and C-reactive protein were determined by standardized methods. Presence (MetS(+)) or absence (MetS(−)) of MetS was determined according to criteria of the International Diabetes Federation. FABP2 genetic polymorphism Ala54Thr (rs1799883) was genotyped with PCR-RFPL.Results:The genotype frequencies for Ala/Ala, Ala/Thr and Thr/Thr genotype were 60, 36 and 6 in MetS(−), and 131, 70 and 13 in MetS(+), respectively, without statistical significance (P = 0.567). Ala/Ala genotype was a subgroup of non-carriers, while Ala/Thr and Thr/Thr genotypes were Thr54-carriers. Median triglyceride concentration was significantly lower in carriers then in non-carriers for whole MetS(+) group (P = 0.050); there were no significant difference between men with MetS (P = 0.144), but there was a difference between women with MetS (P = 0.020). T-test showed that mean HDL cholesterol concentrations in MetS(+) group for Thr54-carriers was significantly higher in whole group (P = 0.001), and for both genders (men P = 0.039; women P = 0.004) as compared to non-carriers.Conclusions:FABP2 genetic polymorphism is associated with lower triglyceride and higher HDL-cholesterol concentrations in elderly subjects with MetS. This genetic variation might be a useful marker for understanding dyslipidemia in MetS.

Association of the FABP2 Ala54Thr polymorphism with type 2 diabetes, obesity, and metabolic syndrome: a population-based case-control study and a systematic meta-analysis

“…The between-study heterogeneity may have arisen for one of the following reasons. First, different diagnostic criteria for MetS: IDF (Csép et al, 2007;Turkovic et al, 2012), American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) (Yamada et al, 2008;Oguri et al, 2009); and Adult Treatment Panel III guidelines (ATPIII) (Vimaleswaran et al, 2006;Miller et al, 2007). Second, ethnicity differences; the T allele frequencies of controlsubject Croatians, Indians, Romanians, Han Chinese, and Japanese were 0.224, 0.269, 0.281, 0.297, and 0.329, respectively.…”

“…Third, selection bias; the differences in age and gender distributions among the studies included and the difference in sample content might also contribute to the heterogeneity. The age of the control subjects ranged from our 52.1 to 78.8 (Turkovic et al, 2012), and sample sizes ranged from 73 (Yamada et al, 2008) to 1114 (Oguri et al, 2009).…”

“…Five studies showed a trend of elevated OR for the allele T (Vimaleswaran et al, 2006;Miller et al, 2007;Csép et al, 2007;Yamada et al, 2008;Oguri et al, 2009). Only one study showed a trend in the opposite direction (Turkovic et al, 2012). A significant association was found for the T allele (OR = 1.18, 95%CI = 1.02-1.36, P = 0.031, heterogeneity, P = 0.011, I 2 = 64.0%) ( Figure 2B).…”

The fatty acid binding protein 2 (FABP2) polymorphism Ala54Thr and obesity in Pakistan: A population based study and a systematic meta-analysis

“…The protein is encoded by FABP2 gene located on chromosomal region 4q28-q31, the gene is approximately 3.4Kb long and contains four exons interrupted by three introns [12]. A number of polymorphisms have been described in the gene to affect various metabolic phenotypes but the most extensively studied polymorphism Ala54Thr (rs1799883) has been reported to be associated particularly with type 2 diabetes, dyslipidemia, stroke, cardiovascular disorders, atherosclerosis, metabolic syndrome, and obesity [13][14][15][16][17][18][19]. It…”

Genotype and allele frequencies of the intestinal fatty acid binding protein-2 gene in two Arab populations

“…In contrast, other studies report no association with the same parameters [20,28,39]. The contradictory results among the different studies may come from the different dietary habits of the analyzed populations [32,41]. Thr-containing protein has been shown to have 2-fold greater affinity for long-chain fatty acids than does Ala-containing protein which may lead to increase absorption and processing of fatty acids [7].…”