High prevalence of hyperuricaemia and its impact on non-valvular atrial fibrillation: the cross-sectional Guangzhou (China) Heart Study

Lin, Weidong; Deng, Hai; Guo, Pi; Liu, Fang‐Zhou; Chen, Ru-yin; Fang, Xianhong; Zhan, Xianzhang; Liao, Hongtao; Huang, Wenxiang; Liu, Yang; Wang, Feng; Zheng, Murui; Liu, Huazhang; Huang, Jun; Wei, Wei; Xue, Yan; Wu, Shu‐Lin

doi:10.1136/bmjopen-2018-028007

“…Coronary heart disease was associated with compound obesity but not central obesity alone, while stroke was associated with neither compound obesity nor central obesity alone. Studies report that the prevalence of central obesity (central obesity alone + compound obesity in our study) varies from 39.0 to 57.4% in other regions of China (6,(22)(23)(24)(25)(26)(27)(28). This variability may be primarily attributed to lifestyle difference throughout China.…”

Section: Discussionmentioning

confidence: 56%

Association Between Obesity Type and Common Vascular and Metabolic Diseases: A Cross-Sectional Study

Zhang

¹

,

Sun

²

,

Jin

³

et al. 2020

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Background: The association between different types of obesity and some chronic diseases in Dehui, Jilin province, China, is still unclear. The aim of our study was to clarify the association between different types of obesity and chronic diseases. Methods: Residents aged 40 years or older were randomly selected using a multistage stratified cluster sampling method. Data were collected by means of face-to-face interview, physical examination, and laboratory examination. Descriptive data analyses were performed, and multiple logistic regression analyses were used to explore the adjusted association between different types of obesity and common vascular and metabolic diseases. Results: The prevalence of general obesity alone, central obesity alone and compound obesity were 0.15, 54.29, and 14.36%, respectively. The prevalence of coronary heart disease, stroke, hypertension, dyslipidemia, and diabetes mellitus was highest in the compound obesity group, and lowest in the non-obesity group. Hypertension, dyslipidemia, and diabetes mellitus were associated with compound obesity and central obesity alone [compound obesity (OR = 4.703, 95% CI: 3.714-5.956 for hypertension; OR = 4.244, 95% CI: 3.357-5.365 for dyslipidemia; OR = 4.575, 95% CI: 3.194-6.552 for diabetes mellitus); central obesity alone (OR = 2.210, 95% CI: 1.901-2.570 for hypertension; OR = 2.598, 95% CI: 2.241-3.012 for dyslipidemia; OR = 2.519, 95% CI: 1.834-3.459 for diabetes mellitus)]. Coronary heart disease was associated with compound obesity (OR = 1.761, 95% CI: 1.141-2.719) but not central obesity alone (OR = 1.409, 95% CI: 0.986-2.013). Stroke was associated with neither compound obesity (OR = 1.222, 95% CI: 0.815-1.833) nor associated with central obesity alone (OR = 1.080, 95% CI: 0.786-1.485). Conclusions: Central obesity alone and compound obesity are associated with the risk of hypertension, hyperlipidemia, and diabetes mellitus. Compound obesity but not central obesity alone is associated with the risk of coronary heart disease, but further research is needed to confirm it. There are no significant relationship between stroke and central obesity alone or compound obesity.

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“…AF is the most common heart rhythm disorder, and its major risk factors include advanced age, hypertension, obesity, diabetes, HF, valvular heart disease, and MI. In recent years, numerous clinical studies have confirmed that hyperuricemia is associated with AF after adjusting for various cardiovascular risk factors, and the correlation is stronger in women than in men (Liang et al, 2016;Zhang et al, 2016;Chen et al, 2017;Kuwabara et al, 2017c;Mantovani et al, 2018;Pak et al, 2018;Black-Maier and Daubert, 2019;Lin et al, 2019). The bases for sex-related differences in high UA and AF or CHD remains unknown.…”

Section: Ua and Afmentioning

confidence: 99%

“…The bases for sex-related differences in high UA and AF or CHD remains unknown. High UA has been associated with endothelial dysfunction in postmenopausal women, suggesting that high UA could be an independent risk factor for cardiovascular disease, including AF and CHD, particularly among postmenopausal women ( Maruhashi et al, 2013 ; Lin et al, 2019 ).…”

Section: Ua and Its Related Molecular Mechanismmentioning

confidence: 99%

Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective

Yu

¹

,

Cheng

²

2020

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Uric acid (UA) is the end product of purine nucleotide metabolism in the human body. Hyperuricemia is an abnormally high level of UA in the blood and may result in arthritis and gout. The prevalence of hyperuricemia has been increasing globally. Epidemiological studies have shown that UA levels are positively correlated with cardiovascular diseases, including hypertension, atherosclerosis, atrial fibrillation (AF), and heart failure (HF). Hyperuricemia promotes the occurrence and development of cardiovascular diseases by regulating molecular signals, such as inflammatory response, oxidative stress, insulin resistance/diabetes, endoplasmic reticulum stress, and endothelial dysfunction. Despite extensive research, the underlying molecular mechanisms are still unclear. Allopurinol, a xanthine oxidase (XO) inhibitor, has been shown to improve cardiovascular outcomes in patients with HF, coronary heart disease (CHD), type 2 diabetes (T2D), and left ventricular hypertrophy (LVH). Whether febuxostat, another XO inhibitor, can improve cardiovascular outcomes as well as allopurinol remains controversial. Furthermore, it is also not clear whether UA-lowering treatment (ULT) can benefit patients with asymptomatic hyperuricemia. In this review, we focus on the latest cellular and molecular findings of cardiovascular disease associated with hyperuricemia and clinical data about the efficacy of ULT in patients with cardiovascular disease.

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“…We started the Guangzhou (China) Heart Study in 2015 (G1 Study). A 5-stage, stratified multistage random sampling method was used to recruit subjects [ 7 ]. Initially, all the 11 districts were divided into an urban group and a rural group, from which one urban district and one rural district were selected by a simple random sampling method.…”

Section: Methodsmentioning

confidence: 99%

The Evolving Epidemiology of Elderly with Degenerative Valvular Heart Disease: The Guangzhou (China) Heart Study

He

¹

,

Deng

²

,

Jiang

³

et al. 2021

BioMed Research International

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Aim. The present study was aimed at investigating the prevalence, incidence, progression, and prognosis of degenerative valvular heart disease (DVHD) in permanent residents aged ≥65 years from Guangzhou, China. Methods. This was a prospective study based on community population. Over a 3-year span, we conducted repeated questionnaires, blood tests, and echocardiographic and electrocardiogram examinations (2018) of a random sample of initially 3538 subjects. Results. The prevalence of DVHD increased with age, average values being 30.6%, 49.2%, and 62.9% in 65-74, 75-84, and ≥85 years of age, respectively. The incidence rate was 1.7%/year. Aortic stenosis was the result of DVHD, and the mean transvalvular pressure gradient increased by 5.6 mmHg/year. The increase of mild aortic stenosis was lower than that of more severe disease, showing a nonlinear development of gradient, but with great individual variations. Mortality was significantly increased in the DVHD group ( HR = 2.49 ). Risk factors for higher mortality included age ( χ 2 = 1.9 , P < 0.05 ), renal insufficiency ( χ 2 = 12.5 , P < 0.01 ), atrial fibrillation ( χ 2 = 12.2 , P < 0.01 ), mitral regurgitation ( χ 2 = 1.8 , P < 0.05 ), and tricuspid regurgitation ( χ 2 = 6.7 , P < 0.05 ) in a DVHD population. Conclusions. DVHD was highly prevalent among residents in southern China. With the progression of the disease, the mean transvalvular pressure gradient accelerated. DVHD was an independent predictor of death, and the mortality was higher in those with older age, renal insufficiency, atrial fibrillation, mitral regurgitation, and tricuspid regurgitation.

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High prevalence of hyperuricaemia and its impact on non-valvular atrial fibrillation: the cross-sectional Guangzhou (China) Heart Study

Cited by 14 publications

References 35 publications

Association Between Obesity Type and Common Vascular and Metabolic Diseases: A Cross-Sectional Study

Association Between Obesity Type and Common Vascular and Metabolic Diseases: A Cross-Sectional Study

Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective

The Evolving Epidemiology of Elderly with Degenerative Valvular Heart Disease: The Guangzhou (China) Heart Study

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