High prevalence of hypertension and early vascular aging: a screening program in pharmacies in Upper Austria

Danninger, Kathrin; Hafez, Ahmed; Binder, Ronald K.; Hametner, Bernhard; Wassertheurer, Siegfried; Weber, Thomas

doi:10.1038/s41371-019-0222-y

Cited by 16 publications

(8 citation statements)

References 27 publications

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“…In conclusion, the EVA concept has enriched translational research activities to find new mechanisms of CVD risk (46) and also inspired researchers to find new treatment targets to further lower the CVD risk beyond what can be achieved by conventional risk factor control. Screening of EVA has been tried based on measurements at pharmacies offered to the public (47) and seems to be feasible. The most recent development is focused on the opposite of EVA, namely, Healthy Vascular Aging (HVA) or even Super Normal Vascular Aging (SUPERNOVA) in order to understand vascular protection and find new treatment targets.…”

Section: Discussionmentioning

confidence: 99%

Early Vascular Aging in Hypertension

Nilsson

2020

Front. Cardiovasc. Med.

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With increasing age, the cardiovascular risk increases, as does frailty, with negative health consequences such as coronary disease, stroke, and vascular dementia. However, this aging process seems to take a more rapid course in some individuals, as reflected in the Early Vascular Aging (EVA) syndrome that over the recent 10 years has attracted increased attention. The core of the EVA syndrome is arterial stiffness in the media layer of large elastic arteries, a process that can be measured by pulse wave velocity, for example, along the aorta. Hypertension is a well-known cardiovascular risk factor in its own right, but also linked to the EVA process. However, several studies have shown that non-hemodynamic factors also contribute to arterial stiffness and EVA, such as impaired glucose metabolism, chronic inflammation, and oxidative stress. New perspectives have been introduced for linking early life programming affecting newborn babies and birth weight, with a later risk of hypertension, arterial stiffness and EVA. New drugs are being developed to treat EVA when lifestyle intervention and conventional risk factor controlling drugs are not enough. Finally, the opposite phenotype of EVA is Healthy Vascular Aging (HVA) or even Super Normal Vascular Aging (SUPERNOVA). If protective mechanisms can be found and mapped in these fortunate subjects with a slower than expected aging process, there could exist a potential to find new drug targets for preventive therapy.

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Section: Discussionmentioning

confidence: 99%

Early Vascular Aging in Hypertension

Nilsson

2020

Front. Cardiovasc. Med.

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“…they agree on an association of hypertension and heart attack) [7]. However, only 15% identified themselves as hypertensive [7], whereas studies showed that 38.1% of all subjects in Austria have a blood pressure higher than 140/90 mm Hg [8]. Numbers for the city of Salzburg and the surrounding areas are missing, uncovering a gap in local research on this field.…”

Section: Introductionmentioning

confidence: 98%

Paracelsus 10,000: An Observational Cohort Study About the Health Status of the Population of Salzburg, Austria. Rationale, Objectives and Study Design

2023

PPExMed

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Background/Aims: Paracelsus 10,000 is an observational cohort study with the objective to investigate the health status of the population in and around the city of Salzburg. The focus lies on common non-communicable diseases, mainly cardiovascular, cerebrovascular, and metabolic diseases, and their risk factors. The aim of the study is to establish a large database enabling to study associations between life style, genetic factors and development of common diseases. Extensive phenotyping and biobanking constitute a basis for preventive measures, multi-omics and precision medicine. Methods: Inhabitants of the city of Salzburg and the surrounding areas were randomly selected and underwent a detailed investigation: The program included medical examinations, as well as assessments on mental disorders and life style including nutrition and physical activity. From all study participants biological samples were stored in a biobank at -80°C enabling future investigations of biomarkers and utilization of the whole spectrum of multi-omics. Results: Between the years 2013 and 2020, 10,044 participants, 5,176 women and 4,868 men aged between 40 and 77 years, completed a baseline assessment. Special emphasis was put on participants between 50 and 59 years old, representing an age group especially prone to changes in health status. In this group, 2,606 participants underwent an extended investigation program. Conclusion: The Paracelsus 10,000 study has the potential to gain new insight into the role of associations between genetic predisposition and life style factors for disease development in the Salzburg population. This report describes rationale, objectives and design of the study and provides insight into the main characteristics of the study cohort.

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“…they agree on an association of hypertension and heart attack) [3]. However, only 15% identi ed themselves as hypertensive [3], whereas studies showed that 38,1% of all subjects in Austria have a blood pressure higher than 140/90 mm Hg [4].…”

Section: Introductionmentioning

confidence: 99%

Paracelsus 10,000: A Prospective Cohort Study Based On The Population of Salzburg, Austria. Rationale, Objectives And Study Design

Frey

Langthaler

Raphaelis

et al. 2021

Preprint

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Paracelsus 10,000 is a prospective cohort study with the objective to investigate the health status of the population in and around the city of Salzburg. The focus lies on common non-communicable diseases, mainly cardiovascular and cerebrovascular diseases, and their risk factors in a population-based cohort aged between 40 and 70 years. Between the years 2013 and 2020, 10,062 randomly selected participants (w: 5,187, m: 4,875) were investigated, of whom 2,620 underwent an intensified examination. The program consists not only of medical examinations, but was extended to inventories on mental disorders, lifestyle including nutrition and physical activity. From all study participants biological samples were stored in a biobank at -80°C enabling future investigations of biomarkers and utilization of the whole spectrum of multi-omics. The first follow-up phase of the study has started in late 2020 and will allow us to investigate the development of common non-communicable diseases occurring over time in the cohort of the Paracelsus 10,000 study. This gives the study a unique position within the framework of Austrian epidemiological research with the potential to gain new insight into the role of interaction between genetic predisposition and lifestyle factors for disease development in the Salzburg population. Obtaining high-quality epidemiological data is also of particular relevance for the development of evidence-based prevention strategies. This report describes rationale, objectives and design of the study and provides insight into the main characteristics of the study cohort.

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High prevalence of hypertension and early vascular aging: a screening program in pharmacies in Upper Austria

Cited by 16 publications

References 27 publications

Early Vascular Aging in Hypertension

Early Vascular Aging in Hypertension

Paracelsus 10,000: An Observational Cohort Study About the Health Status of the Population of Salzburg, Austria. Rationale, Objectives and Study Design

Paracelsus 10,000: A Prospective Cohort Study Based On The Population of Salzburg, Austria. Rationale, Objectives And Study Design

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