High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners

Meuleman, Christel; Vandenabeele, Birgit; Fieuws, Steffen; Spiessens, Carl; Timmerman, Dirk; D’Hooghe, Thomas

doi:10.1016/j.fertnstert.2008.04.056

Cited by 499 publications

(362 citation statements)

References 23 publications

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“…The disease prevalence increases to 30-40% among infertile women (2,3). The development and persistence of endometriosis is associated with alterations in the immune and endocrine systems (3,4).…”

Section: Introductionmentioning

confidence: 99%

Polymorphic variants in vitamin D signaling pathway genes and the risk of endometriosis-associated infertility

Szczepańska

Mostowska

Wirstlein

et al. 2015

Molecular Medicine Reports

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Abstract. It has recently been reported that vitamin D blood plasma levels are associated with reduced risk of endometriosis. The present study aimed to investigate whether the vitamin D binding protein (GC), vitamin D receptor (VDR), and retinoid X receptor (RXR) gene variants may be genetic risk factors for endometriosis-associated infertility. The subjects consisted of 154 women with endometriosis-associated infertility and 347 controls. Using polymerase chain reaction restriction fragment length polymorphism and high resolution melt techniques, the GC rs1155563, rs2298849 and rs7041; RXRA rs10881578, rs10776909 and rs749759; VDR BsmI rs1544410; and FokI rs2228570 single nucleotide polymorphisms (SNPs) were investigated in the patients with endometriosis and the healthy controls. The results indicated that no significant differences were observed between the genotype and allele frequencies of all experimental SNPs in the vitamin D signaling pathway genes in women with endometriosis-associated infertility and controls. However, a significant association was present between the A-T haplotype, consisting of VDR rs1544410 and rs222857 minor alleles, and endometriosis-associated infertility [OR=1.659 (1.122-2.453), P=0.011]. The results of the present study suggested that VDR gene variants act as genetic risk factors for endometriosis-associated infertility.

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Section: Introductionmentioning

confidence: 99%

Polymorphic variants in vitamin D signaling pathway genes and the risk of endometriosis-associated infertility

Szczepańska

Mostowska

Wirstlein

et al. 2015

Molecular Medicine Reports

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show abstract

“…[10][11][12] In one of the studies, it has been shown that approximately 47% of women with infertility have endometriosis. 13 In a study done by Tsuzi et al, the prevalence was 63%. In our study it is 73.33%.…”

Section: Discussionmentioning

confidence: 95%

Study of endometriosis in women of reproductive age, laparoscopic management and its outcome

Valson

Kulkarni

Teli

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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“…The prevalence of endometriosis was 47% (104/221), including stage I (39%, 41/104), stage II (24%, 25/104), stage III (14%, 15/104), and stage IV (23%, 23/104) disease. 11 Multiple other studies, the majority of which were retrospective, also indicated that the monthly fecundity of patients with endometriosis may be decreased by half compared to women without the disease. The precise cause-effect relationship between endometriosis and infertility remains controversial.…”

Section: Discussionmentioning

confidence: 99%

Endometriosis: Correlation of Severity of Pain with Stages of Disease

Chowdhury

Mahmud

Chowdhury

2017

J. Bangladesh Coll. Phys.

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Objective: To assess the prevalence and severity of pain in patients with endometriosis and to evaluate the relationship between the severity of pelvic pain with different stages of endometriosis.Methods: A prospective observational study conducted among 65 patients diagnosed with endometriosis during surgery in Infertility Management Center Dhaka, a specialized center for treatment of infertility and assisted reproductive technologies from January 2008 to January 2009.Result: Majority of the patients were between 26-30 years. Pelvic pain was the predominant symptom in 78.5% patients and the rest were asymptomatic. Among the symptomatic patients, most common symptom was dysmenorrhoea (n=47, 92.1%).When severity of pain was graded; it was observed that most (37%) presented with moderate pain. Infertility was present in 85% patients, mostly (n- 47 =74%) in primary sub fertility group. The commonest site of endometriosis was uterosacral ligament (n-58=89%) and ovarian endometriosis is noted in (63%) cases. Most of the lesions (35%) were black, haemosiderin deposits. When r-ASRM staging system was applied, majority (58.4%) of the patients was in stage IV disease and most of the patients (31%) with endometrioma were in stage IV disease. The study revealed a strong positive correlation between severe pain and stage IV disease (Correlation co efficient 0.711). Moderate forms of pain and severity of disease did not show any positive correlation in this study (Correlation co efficient 0.390). There was negative correlation between milder forms of pain with severity of disease.Conclusion: There was no relationship between frequency and severity of pain symptoms and disease stage of endometriosis.J Bangladesh Coll Phys Surg 2016; 34(3): 135-139

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High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners

Cited by 499 publications

References 23 publications

Polymorphic variants in vitamin D signaling pathway genes and the risk of endometriosis-associated infertility

Polymorphic variants in vitamin D signaling pathway genes and the risk of endometriosis-associated infertility

Study of endometriosis in women of reproductive age, laparoscopic management and its outcome

Endometriosis: Correlation of Severity of Pain with Stages of Disease

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