High prevalence of diabetic neuropathy in population-based patients diagnosed with type 2 diabetes in the Shanghai downtown

Lü, Bin; Yang, Zhihong; Wang, Mei; Yang, Zhen; Gong, Wei; Yang, Yehong; Wen, Jie; Zhang, Zhaoyun; Zhao, Na; Zhu, Xiangjia; Hu, Renming

doi:10.1016/j.diabres.2010.02.002

Cited by 63 publications

(64 citation statements)

References 24 publications

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“…Diabetes patients, especially those with KDM, had the highest prevalence of DPN (13.1%) among all groups. Many previous studies on DPN report a wide range of prevalence estimates, from 7.8%–61.8% in different populations with type 2 DM [2], [29], [34]–[35]. The marked variation in the prevalence of neuropathy in the present study might be due to the diagnostic criteria of neuropathy, study design, sample selection, ethnicity, year when the study was conducted, and the age and sex structure of the study population itself.…”

Section: Discussionmentioning

confidence: 57%

“…Our previous study revealed that up to 61.8% of patients diagnosed with type 2 diabetes in downtown Shanghai have peripheral neuropathy (PN) according to the evaluation of vibration perception threshold and 10-g Semmes–Weinstein monofilament [2]. However, there are limited data concerning the prevalence of neuropathies in the pre-diabetes population, especially in Han Chinese.…”

Section: Introductionmentioning

confidence: 99%

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Determination of Peripheral Neuropathy Prevalence and Associated Factors in Chinese Subjects with Diabetes and Pre-Diabetes – ShangHai Diabetic neuRopathy Epidemiology and Molecular Genetics Study (SH-DREAMS)

Lü

Wen

et al. 2013

PLoS ONE

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ObjectiveThis study determined the prevalence and factors associated with peripheral neuropathy (PN) in subjects with diabetes mellitus, impaired glucose regulation (IGR), and normal glucose tolerance (NGT) in a community-based Chinese population.Research Design and MethodsA total of 2035 subjects in Shanghai were classified as having NGT, IGR, or diabetes. All subjects underwent complete foot examination. PN was assessed according to the neuropathy symptom and neuropathy disability scores. Binary logistic regression was performed to analyze the contributions of factors to PN.ResultsThe prevalence of PN was 8.4%, 2.8%, and 1.5% in diabetes mellitus, IGR, and NGT subjects, respectively (P<0.05 for diabetes vs. NGT, and IGR). The subjects with known diabetes had the highest frequency of PN (13.1%). Among the subjects without diabetes, those with PN were older, had a higher waist circumference and 2-h postprandial plasma glucose levels, and were more likely to be hypertensive. Among the IGR subjects, other than age, the 2-h postprandial plasma glucose level was an independent factor significantly associated with PN. Meanwhile, among the subjects with diabetes, PN was associated with fasting plasma glucose, duration of diabetes, and decreased estimated glomerular filtration rate.ConclusionsThe prevalence of PN is slightly higher in individuals with IGR than that in individuals with NGT, but small fibre damage in IGR as the earliest nerve fibre deficit may be underestimated in our study. As an independent risk factor, postprandial plasma glucose level may be an important target for strategies to prevent or improve PN in IGR subjects.

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Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Determination of Peripheral Neuropathy Prevalence and Associated Factors in Chinese Subjects with Diabetes and Pre-Diabetes – ShangHai Diabetic neuRopathy Epidemiology and Molecular Genetics Study (SH-DREAMS)

Lü

Wen

et al. 2013

PLoS ONE

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“…The prevalence of DPN in Korea varies from 13.1% to 61.8%, depending on the population being studied [4,14,15]. This inconsistency may be attributed to the various types of diabetes, differences in study design, sample selection, and diagnostic criteria, and variation in race, age, sex, and duration of diabetes in the populations studied.…”

Section: Prevalence Of Dpn In Koreamentioning

confidence: 99%

Current Status of Diabetic Peripheral Neuropathy in Korea: Report of a Hospital-Based Study of Type 2 Diabetic Patients in Korea by the Diabetic Neuropathy Study Group of the Korean Diabetes Association

Won

Kim

et al. 2014

Diabetes Metab J

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Diabetic peripheral neuropathy (DPN) is the most common complication associated with diabetes. DPN can present as a loss of sensation, may lead to neuropathic ulcers, and is a leading cause of amputation. Reported estimates of the prevalence of DPN vary due to differences in study populations and diagnostic criteria. Furthermore, the epidemiology and clinical characteristics of DPN in Korean patients with type 2 diabetes mellitus (T2DM) are not as well understood as those of other complications of diabetes such as retinal and renal disease. Recently, the Diabetic Neuropathy Study Group of the Korean Diabetes Association (KDA) conducted a study investigating the impact of DPN on disease burden and quality of life in patients with T2DM and has published some data that are representative of the nation. This review investigated the prevalence and associated clinical implications of DPN in Korean patients with diabetes based on the KDA study.

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“…The treatment options are limited, which may explain why up to 50% have not requested or received treatment for the condition [8]. The prevalence of DPN observed in the Chinese population with type 2 diabetes who were older than 30 years of age in Shangai reached up to 61.8% [9]. In Puerto Rico, the prevalence of diabetes is much higher than in the mainland USA and other countries, achieving levels of 12.9% during 2009.…”

Section: Prevalence Of Dpnmentioning

confidence: 99%

Metabolic Correction in the Management of Diabetic Peripheral Neuropathy: Improving Clinical Results Beyond Symptom Control

Miranda-Massari

González²,

Jiménez³

et al. 2011

CCP

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Current Clinical Management Guidelines of Diabetic Peripheral Neuropathy (DPN) are based on adequate glucose control and symptomatic pain relief. However, meticulous glycemic control could delay the onset or slow the progression of diabetic neuropathy in patients with DM type 2, but it does not completely prevent the progression of the disease. Complications of DPN as it continues its natural course, produce increasing pain and discomfort, loss of sensation, ulcers, infections, amputations and even death. In addition to the increased suffering, disability and loss of productivity, there is a very significant economic impact related to the treatment of DPN and its complications. In USA alone, it has been estimated that there are more than 5,000,000 patients suffering from DPN and the total annual cost of treating the disease and its complications is over $10,000 million dollars. In order to be able to reduce complications of DPN, it is crucial to improve or correct the metabolic conditions that lead to the pathology present in this condition. Pathophysiologic mechanisms implicated in diabetic neuropathy include: increased polyol pathway with accumulation of sorbitol and reduced Na + /K + -ATPase activity, microvascular damage and hypoxia due to nitric oxide deficit and increased oxygen free radical activity. Moreover, there is a decrease in glutathione and increase in homocysteine. Clinical trials in the last two decades have demonstrated that the use of specific nutrients can correct some of these metabolic derangements, improving symptom control and providing further benefits such as improved sensorium, blood flow and nerve regeneration. We will discuss the evidence on lipoic acid, acetyi-L-carnitine, benfotiamine and the combination of active B vitamins L-methylfolate, methylcobalamin and piridoxal-6-phosphate. In addition, we discuss the role of metforrnin, an © 2011 Bentham Science Publishers * Address correspondence to this author at the Room 420, School of Pharmacy Medical Sciences Campus-University of Puerto Rico, PO Box 365067, San Juan, Puerto Rico; Tel: (787) important drug in the management of diabetes, and the presence of specific polymorphic genes, in the risk of developing DPN and how metabolic correction can reduce these risks.

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High prevalence of diabetic neuropathy in population-based patients diagnosed with type 2 diabetes in the Shanghai downtown

Cited by 63 publications

References 24 publications

Determination of Peripheral Neuropathy Prevalence and Associated Factors in Chinese Subjects with Diabetes and Pre-Diabetes – ShangHai Diabetic neuRopathy Epidemiology and Molecular Genetics Study (SH-DREAMS)

Determination of Peripheral Neuropathy Prevalence and Associated Factors in Chinese Subjects with Diabetes and Pre-Diabetes – ShangHai Diabetic neuRopathy Epidemiology and Molecular Genetics Study (SH-DREAMS)

Current Status of Diabetic Peripheral Neuropathy in Korea: Report of a Hospital-Based Study of Type 2 Diabetic Patients in Korea by the Diabetic Neuropathy Study Group of the Korean Diabetes Association

Metabolic Correction in the Management of Diabetic Peripheral Neuropathy: Improving Clinical Results Beyond Symptom Control

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