Current Status of Diabetic Peripheral Neuropathy in Korea: Report of a Hospital-Based Study of Type 2 Diabetic Patients in Korea by the Diabetic Neuropathy Study Group of the Korean Diabetes Association

Abstract

Diabetic peripheral neuropathy (DPN) is the most common complication associated with diabetes. DPN can present as a loss of sensation, may lead to neuropathic ulcers, and is a leading cause of amputation. Reported estimates of the prevalence of DPN vary due to differences in study populations and diagnostic criteria. Furthermore, the epidemiology and clinical characteristics of DPN in Korean patients with type 2 diabetes mellitus (T2DM) are not as well understood as those of other complications of diabetes such as retinal and renal disease. Recently, the Diabetic Neuropathy Study Group of the Korean Diabetes Association (KDA) conducted a study investigating the impact of DPN on disease burden and quality of life in patients with T2DM and has published some data that are representative of the nation. This review investigated the prevalence and associated clinical implications of DPN in Korean patients with diabetes based on the KDA study.

Associations of serum anti-ganglioside antibodies and inflammatory markers in diabetic peripheral neuropathy

“…As the initial finding in our study, DPN was notably correlated with parameters such as smoking, drinking, and hypertensive populations, and HbA1c, FPG, TC, TG, and LDL-C and HDL-C. To the best of our knowledge, the development and progression of DPN was independent of risk factors including cigarette smoking, hypertension, and alcohol consumption [18]. Also, previous studies found that elevated levels of HbA1c, FPG, TG, and LDL-C, but declined levels of HDL-C have been implicated in the progression of DPN [19][20][21].…”

Effect of Socio-Economic Status on the Prevalence of Diabetes

“…1 Diabetes causes secondary pathophysiological changes, damage, and failure in multiple organ systems, for example retinopathy with potential blindness, nephropathy with potential end-stage renal disease, neuropathy, cardiovascular diseases, and/or peripheral vascular disease. 2 , 3 According to Statistics Korea, diabetes is the fifth leading cause of death in South Korea. 3 , 4 As Korean society has become more industrialized and westernized, the prevalence of diabetes has increased rapidly.…”

Study of Peripheral Neuropathy in Children With Type 1 Diabetes Mellitus at Zagazig University Hospitals

“…In the current research, the sensory manifestations are the most common presentation of neuropathy in diabetic patients. Sensory nerve damage occurs earlier than motor nerve damage, perhaps due to thinner and longer nerves in sensory nerves, which could be more vulnerable to metabolic insults [30,31] .…”