High Prevalence of Carbapenem-Resistant
 Acinetobacter baumannii
 Carrying the
 bla
 OXA-143
 Gene in Brazilian Hospitals

Antonio, Charline Santos; Neves, Patrícia; Medeiros, Michelle; Mamizuka, Elsa M.; Araújo, Maria; Lincopán, Nilton

doi:10.1128/aac.01102-10

Cited by 50 publications

(48 citation statements)

References 12 publications

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“…A study conducted in the United Kingdom by Turton et al (27) showed that carbapenem hydrolysis by isolates carrying the bla OXA-51-like gene only occurred in bacteria in which ISAba1 was upstream of the gene, suggesting that this IS acted as a promoter for the expression of this gene. Antonio et al (26) reported that, in their study performed in hospitals of the Southeast and South regions of Brazil from 2004 to 2008, ISAba1 was not observed upstream of the bla OXA-51-like gene; furthermore, none of the isolates analyzed showed the carbapenem-resistant phenotype. The results in our study were similar because only 9% (7/78) of the isolates exclusively amplifi ed bla OXA-51-like , and none amplifi ed ISAba1 concomitantly; moreover, all these isolates were susceptible to carbapenems.…”

Section: Discussionmentioning

confidence: 99%

The role of the genetic elements bla oxa and IS Aba 1 in the Acinetobacter calcoaceticus-Acinetobacter baumannii complex in carbapenem resistance in the hospital setting

Kobs¹,

Ferreira

Bobrowicz

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction: Members of the Acinetobacter genus are key pathogens that cause healthcare-associated infections, and they tend to spread and develop new antibiotic resistance mechanisms. Oxacillinases are primarily responsible for resistance to carbapenem antibiotics. Higher rates of carbapenem hydrolysis might be ascribed to insertion sequences, such as the ISAba1 sequence, near bla OXA genes. The present study examined the occurrence of the genetic elements bla OXA and ISAba1 and their relationship with susceptibility to carbapenems in clinical isolates of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex. Methods: Isolates identifi ed over 6 consecutive years in a general hospital in Joinville, Southern Brazil, were evaluated. The investigation of 5 families of genes encoding oxacillinases and the ISAba1 sequence location relative to bla OXA genes was conducted using polymerase chain reaction. Results: All isolates presented the bla OXA-51-like gene (n = 78), and 91% tested positive for the bla OXA-23-like gene (n = 71). The presence of ISAba1 was exclusively detected in isolates carrying the bla OXA-23-like gene. All isolates in which ISAba1 was found upstream of the bla OXA-23-like gene (n = 69) showed resistance to carbapenems, whereas the only isolate in which ISAba1 was not located near the bla OXA-23-like gene was susceptible to carbapenems. The ISAba1 sequence position of another bla OXA-23-like -positive isolate was inconclusive. The isolates exclusively carrying the bla OXA-51-like gene (n = 7) showed susceptibility to carbapenems. Conclusions: The presence of the ISAba1 sequence upstream of the bla OXA-23-like gene was strongly associated with carbapenem resistance in isolates of the A. calcoaceticus-A. baumannii complex in the hospital center studied.

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Section: Discussionmentioning

confidence: 99%

The role of the genetic elements bla oxa and IS Aba 1 in the Acinetobacter calcoaceticus-Acinetobacter baumannii complex in carbapenem resistance in the hospital setting

Kobs¹,

Ferreira

Bobrowicz

et al. 2016

Rev. Soc. Bras. Med. Trop.

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show abstract

“…Similar findig for the same period of time, were refered from the investigation in some other countries such as Brazil or Taiwan [17,18].…”

Section: Discussionmentioning

confidence: 94%

“…All isolated strains belonged to European clone II lineage. [14], although there are data for A.baumanii isolates positive for bla (OXA-23-like) on american continent [17], This clone dispersed very fast in 2012 and achieved the rate of 61,9% (N=84).…”

Section: Discussionmentioning

confidence: 99%

“…Clonal outbreaks of carbapenem-resistant and OXA-23-producing A. baumannii have been reported in many countries, such as Bulgaria, People's Republic of China, Brazil, Iraq, Afghanistan, Spain [9,10,11].…”

Section: Introductionmentioning

confidence: 99%

“…[9,10] Three international A. baumannii clones associated with multidrug resistance (European clones I, II, and III) have been reported).…”

Section: Introductionmentioning

confidence: 99%

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Carbapenem Resistant Acinetobacter Baumanii Versus MRSA Isolates in ICU in Clinical Center Skopje

Popovska¹

2014

EJPM

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Abstract:Backgorund: Acinetobacter baumannii is often referred to as the "Gram-negative methicillin-resistant Staphylococcus aureus", because it is frequently resistant to antibiotics. Clonal outbreaks of carbapenem-resistant and OXA-23-producing A. baumannii have been reported worldwide. Aim: The goal of this study was to promote the phenomenon of disbalance in endemic hospital ECO system which included increase of carbapenemase-resistant Acinetobacter baumanii on account of reduction of MRSA rate in surgical ICU and it's clonal relatedness as well as the specific precautions. Material nad Methods: Computer database from 1994 -2012 from surgical ICU patients in the Clinical Center Skopje was used as basic material for this study. Comparative study indicated 2007/8 as a break point period in which almost a twofold decrease of MRSA rates (from over 80% to 45%) versus increased rates of Acinetobacter baumanii (from 29% to 40%) was observed. In 2011 the very first eight strains of carbapenem resistant (resistant to imipenem and meropenem) A. baumannii, were observed. Disc diffusion and VITEK were used for antibiotic susceptibility testing. Resultes: Three distinct strains were detected by PFEGE and were designated as UKIM01AC-1 (5 strains), UKIM01AC-2 (two strains) and 642/2 (one strain). UKIM01AC-1 representatives were PCR positive for bla , in addition to the bla (OXA-51-like) gene which is intrinsic in Acinetobacter baumannii. All isolated strains belonged to European clone II lineage. Conclusion: This clone dispersed very fast in 2012 and achieved the rate of 61.9%. This implicated changes in infection control precautions.

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Detection of blaOXA-23 in Acinetobacter spp. isolated from patients of a university hospital

Corrêa

Botelho

Barbosa

et al. 2012

The Brazilian Journal of Infectious Diseases

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High Prevalence of Carbapenem-Resistant Acinetobacter baumannii Carrying the bla _OXA-143 Gene in Brazilian Hospitals

Cited by 50 publications

References 12 publications

The role of the genetic elements bla oxa and IS Aba 1 in the Acinetobacter calcoaceticus-Acinetobacter baumannii complex in carbapenem resistance in the hospital setting

The role of the genetic elements bla oxa and IS Aba 1 in the Acinetobacter calcoaceticus-Acinetobacter baumannii complex in carbapenem resistance in the hospital setting

Carbapenem Resistant Acinetobacter Baumanii Versus MRSA Isolates in ICU in Clinical Center Skopje

Detection of blaOXA-23 in Acinetobacter spp. isolated from patients of a university hospital

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High Prevalence of Carbapenem-Resistant Acinetobacter baumannii Carrying the bla OXA-143 Gene in Brazilian Hospitals

Cited by 50 publications

References 12 publications

The role of the genetic elements bla oxa and IS Aba 1 in the Acinetobacter calcoaceticus-Acinetobacter baumannii complex in carbapenem resistance in the hospital setting

The role of the genetic elements bla oxa and IS Aba 1 in the Acinetobacter calcoaceticus-Acinetobacter baumannii complex in carbapenem resistance in the hospital setting

Carbapenem Resistant Acinetobacter Baumanii Versus MRSA Isolates in ICU in Clinical Center Skopje

Detection of blaOXA-23 in Acinetobacter spp. isolated from patients of a university hospital

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High Prevalence of Carbapenem-Resistant Acinetobacter baumannii Carrying the bla _OXA-143 Gene in Brazilian Hospitals