High Prevalence of Apical Periodontitis in Patients With Inflammatory Bowel Disease: An Age- and Gender- matched Case-control Study

Borrego, Manuel Poyato; Segura-Sampedro, Juan José; Martín-González, Jénifer; Torres-Domínguez, Yolanda; Velasco‐Ortega, Eugenio; Segura-Egea, Juan José

doi:10.1093/ibd/izz128

Cited by 36 publications

(43 citation statements)

References 39 publications

(63 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The recruitment method of the patients was similar to that used in previous studies [ 33 , 34 , 35 , 36 ]. Apical periodontitis was diagnosed using the ‘periapical index’ (PAI) scoring system [ 7 ], widely used in epidemiological and clinical studies in which the presence of radiolucent periapical lesions is assessed to determine the prevalence of AP [ 3 , 37 , 38 ]. Although there may be an underestimation of lesions when panoramic radiography was used [ 39 ], the difference with periapical radiography is not statistically significant [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…The possibility of comparisons between studies carried out with calibrated observers makes this system attractive [ 44 ] to better standardize the evaluations and allow comparison with the results of other researchers. Additionally, although the PAI score system was first described for periapical radiographs [ 26 ], it has been used in many epidemiological studies for panoramic radiographs [ 22 , 24 , 27 , 37 , 38 , 45 , 46 ]. The possibility of comparisons among the studies carried out with calibrated observers makes this system attractive [ 41 ], in order to better standardize the evaluations and allow the comparison with the result of other investigators.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between Apical Periodontitis and Metabolic Syndrome and Cardiovascular Events: A Cross-Sectional Study

González-Navarro

Segura-Egea

Estrugo‐Devesa

et al. 2020

JCM

Self Cite

View full text Add to dashboard Cite

Aim: Both apical periodontitis (AP) and metabolic syndrome (MetS) are associated with atherosclerotic cardiovascular disease (ACVD), the main cause of cardiovascular events. The aim of this study was to investigate the prevalence of AP and the oral inflammatory burden in control subjects and patients suffering cardiovascular events, analyzing the possible association between AP and the oral inflammatory burden with MetS. Materials and Methods: Using a cross-sectional design, 83 patients suffering a cardiovascular event were recruited in the study group (SG), and 48 patients without cardiovascular events were included in the control group (CG). Periapical index (PAI) was used to diagnose AP, and total dental index (TDI) was used to assess the total oral inflammatory burden. Diagnosis of MetS was made by meeting three or more American Heart Association Scientific Statement components. Results: In the multivariate logistic regression analysis, the number of teeth with AP (OR = 2.3; 95% C.I. = 1.3–4.3; p = 0.006) and TDI scores (OR = 1.5; 95% C.I. = 1.2–1.9; p = 0.001), significantly correlated with cardiovascular events. MetS was strongly associated (OR = 18.0; 95% C.I. = 6.5–49.7; p = 0000) with cardiovascular events. Higher TDI scores were significantly associated with MetS (OR = 1.3; 95% C.I. = 1.1–1.6; p = 0.003. Neither the number of root-filled teeth (RFT) (OR = 0.9; 95% C.I. = 0.6–1.3; p = 0.61) nor the number of teeth with apical periodontitis (OR = 1.1; 95% C.I. = 0.8–1.7; p = 0.49) were associated with MetS. Conclusions: Apical periodontitis is significantly associated with cardiovascular events. Total oral inflammatory burden assessed by TDI, but not AP alone, is associated with MetS.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Relationship between Apical Periodontitis and Metabolic Syndrome and Cardiovascular Events: A Cross-Sectional Study

González-Navarro

Segura-Egea

Estrugo‐Devesa

et al. 2020

JCM

Self Cite

View full text Add to dashboard Cite

show abstract

“…Seven studies were mistakenly classified by their authors as retrospective studies, when in fact they were cross-sectional (Bołtacz-Rzepkowska & Laszkiewicz 2005, Gumru et al 2011, Ureyen Kaya et al 2013, Willershausen et al 2014, Hussein et al 2016, Jalali et al 2017, Piras et al 2017. Four studies were classified as case-control, but based on their design, they were also cross-sectional studies (Hommez et al 2008, Pasqualini et al 2012, Leal et al 2015, Poyato-Borrego et al 2019. Only one study was a real case-control (Khalighinejad et al 2017a).…”

Section: Study Selection and Study Characteristicsmentioning

confidence: 99%

The global prevalence of apical periodontitis: a systematic review and meta‐analysis

Michelon²,

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The risk for periodontitis among patients with IBD has been reported in recent studies[ 15 , 26 - 28 ]. In a matched-cohort study demonstrating the prevalence and relative risk of periodontitis, patients with CD were at a 1.36-fold increased risk for periodontitis than controls[ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Periodontitis combined with smoking increases risk of the ulcerative colitis: A national cohort study

Kang

Chun

Kim

et al. 2020

WJG

View full text Add to dashboard Cite

BACKGROUND Periodontitis is a chronic inflammation of periodontal tissues. The effect of periodontitis on the development of inflammatory bowel disease (IBD) remains unclear. AIM To assessed the risk of IBD among patients with periodontitis, and the risk factors for IBD related to periodontitis. METHODS A nationwide population-based cohort study was performed using claims data from the Korean National Healthcare Insurance Service. In total, 9950548 individuals aged ≥ 20 years who underwent national health screening in 2009 were included. Newly diagnosed IBD [Crohn’s disease (CD), ulcerative colitis (UC)] using the International Classification of Disease 10 th revision and rare intractable disease codes, was compared between the periodontitis and non-periodontitis groups until 2017. RESULTS A total of 1092825 individuals (11.0%) had periodontitis. Periodontitis was significantly associated with older age, male gender, higher body mass index, quitting smoking, not drinking alcohol, and regular exercise. The mean age was 51.4 ± 12.9 years in the periodontitis group and 46.6 ± 14.2 years in the non-periodontitis group ( P < 0.01), respectively. The mean body mass index was 23.9 ± 3.1 and 23.7 ± 3.2 in the periodontitis and non-periodontitis groups, respectively ( P < 0.01). Men were 604307 (55.3%) and 4844383 (54.7%) in the periodontitis and non-periodontitis groups, respectively. The mean follow-up duration was 7.26 years. Individuals with periodontitis had a significantly higher risk of UC than those without periodontitis [adjusted hazard ratio: 1.091; 95% confidence interval (CI): 1.008-1.182], but not CD (adjusted hazard ratio: 0.879; 95% confidence interval: 0.731-1.057). The risks for UC were significant in the subgroups of age ≥ 65 years, male gender, alcohol drinker, current smoker, and reduced physical activity. Current smokers aged ≥ 65 years with periodontitis were at a 1.9-fold increased risk of UC than non-smokers aged ≥ 65 years without periodontitis. CONCLUSION Periodontitis was significantly associated with the risk of developing UC, but not CD, particularly in current smokers aged ≥ 65 years.

show abstract

High Prevalence of Apical Periodontitis in Patients With Inflammatory Bowel Disease: An Age- and Gender- matched Case-control Study

Abstract: Results of this age- and gender- matched case-control study show that the prevalence of apical periodontitis, diagnosed as radiolucent periapical lesions, is higher in patients with inflammatory bowel disease than in healthy control subjects (OR = 5.71; p = 0.0048).

Cited by 36 publications

References 39 publications

Relationship between Apical Periodontitis and Metabolic Syndrome and Cardiovascular Events: A Cross-Sectional Study

Relationship between Apical Periodontitis and Metabolic Syndrome and Cardiovascular Events: A Cross-Sectional Study

The global prevalence of apical periodontitis: a systematic review and meta‐analysis

Periodontitis combined with smoking increases risk of the ulcerative colitis: A national cohort study

Contact Info

Product

Resources

About