We have measured thermoelectric properties of Ta2PdX6 (X=S, Se) around room temperature using single crystal samples. We find that the power factor of Ta2PdX6 is relatively high from middle-low to room temperatures, and notably Ta2PdSe6 shows the largest power factor among thermoelectric materials with an electrical conductivity of 10 -2 Ωcm at 300 K. Ta2PdS6 will be a possible candidate for a Peltier cooling material if the lattice thermal conductivity is reduced by chemical substitution.Transition-metal chalcogenides have attracted much attention due to their unique physical properties arising from their low-dimensionality. Charge density wave 1) , superconductivity 2) , and topologically nontrivial electronic phases 3) in binary transition-metal dichalcogenides have been one of the central issues of the condensed matter physics. Ternary transition-metal chalcogenides with strong one-dimensionality (1D) also attract keen interests due to their exotic physical properties. For instance, a quasi 1D telluride Ta4SiTe4 and its sister compounds show good thermoelectric properties from middle-low to room temperatures 4)-6) . Another quasi 1D selenide Ta2NiSe5 is a candidate of the excitonic insulator (EI) 7)-9) , which has been pursued for long time from its theoretical prediction in the 1960s.Ta2PdX6 (X=S, Se), which was synthesized in 1985 10) , is yet another 1D ternary transitionmetal chalcogenide. This compound crystallizes in the monoclinic structure with the space