High plasma levels of soluble ST2 but not its ligand IL-33 is associated with severe forms of pediatric dengue

Guerrero, Christian D.; Arrieta, Andres F.; Ramirez, N.; Rodríguez, Luz-Stella; Vega, Rocío; Bosch, Irene; Rodríguez, Jairo; Narváez, Carlos F.; Salgado, Doris M.

doi:10.1016/j.cyto.2012.12.024

Cited by 35 publications

(46 citation statements)

References 46 publications

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“…Among them, one reported elevation in IL-10 (Malavige et al, 2013a), congruent with the seven WHO (1997) guideline-utilizing studies that reported elevations in IL-10 in DHF patients (Table 3), and one study reported elevated IL-10 levels in DwoWS, DwWS and SD patients compared to controls (Guerrero et al, 2013). Two studies reported elevations in sST2 (IL-1RL1) (Arias et al, 2014;Guerrero et al, 2013) in SD patients in levels above those of DwoWS and DwWS (Arias et al, 2014;Guerrero et al, 2013). The same studies reported increased IL-6 levels in SD and DwWS relative to patients with DwoWS.…”

Section: Prognostication Marker Candidates: Who (2009) Sdsupporting

confidence: 68%

“…A total of 19 out of 24 studies were case-control studies (Arias et al, 2014;Bozza et al, 2008;Brasier et al, 2012;Butthep et al, 2012;Chen et al, 2005;Furuta et al, 2012;Green et al, 1999a, b;Guerrero et al, 2013;Houghton-Triviño et al, 2010;De La Cruz Hern andez et al, 2014;Laur et al, 1998;Levy et al, 2010;Malavige et al, 2013a;Nguyen et al, 2004;Del Moral-Hern andez et al, 2014;P erez et al, 2004;Soundravally et al, 2014;Wang et al, 2007), and the remaining 5 studies were prospective cohort studies (de-Oliveira-Pinto et al, 2012;Kurane et al, 1991Kurane et al, , 1993Suharti et al, 2003). Comparison groups were healthy controls, patients with other febrile illness (OFI) or non-severe disease patients (DF or non-SD); however, comparisons made between SD and non-SD cases were considered most ideal for the purpose of this review.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The remaining studies had wider blood sampling windows, ranging from 1 to 10 days from symptom onset (Arias et al, 2014;Bozza et al, 2008;Chen et al, 2005;de-Oliveira-Pinto et al, 2012;Guerrero et al, 2013;Houghton-Triviño et al, 2010;Kurane et al, 1991Kurane et al, , 1993Laur et al, 1998;Levy et al, 2010;Del Moral-Hern andez et al, 2014;Nguyen et al, 2004;Suharti et al, 2003). A majority of studies (21/24, 87.5 %) employed ELISAs for quantification of single cytokine/chemokine, or multiplexed suspension bead immunoassays for broader profiling.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…A majority of studies (21/24, 87.5 %) employed ELISAs for quantification of single cytokine/chemokine, or multiplexed suspension bead immunoassays for broader profiling. Three studies (12.5 %) used cytometric bead arrays (Guerrero et al, 2013;Houghton-Triviño et al, 2010;De La Cruz Hern andez et al, 2014).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Of the selected 24 studies, 4 studies (16.7 %) employed the WHO (2009) case definition (Arias et al, 2014;de-OliveiraPinto et al, 2012;Guerrero et al, 2013;Malavige et al, 2013a). Among them, one reported elevation in IL-10 (Malavige et al, 2013a), congruent with the seven WHO (1997) guideline-utilizing studies that reported elevations in IL-10 in DHF patients (Table 3), and one study reported elevated IL-10 levels in DwoWS, DwWS and SD patients compared to controls (Guerrero et al, 2013).…”

Section: Prognostication Marker Candidates: Who (2009) Sdmentioning

confidence: 99%

See 4 more Smart Citations

Markers of dengue severity: a systematic review of cytokines and chemokines

Lee

Leong

Wilder‐Smith

2016

Journal of General Virology

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The prognosis of dengue remains a challenge in the early, objective triage of patients with dengue fever of differing severity. Circulating immuno-modulating proteins have brought new possibilities as prognostic markers of severe dengue (SD). This systematic review is devoted to understanding the potential utility of blood-based cytokines and chemokines as prognostication markers of SD based on the current literature. PubMed and Embase were searched. Of 794 candidate articles, 685 abstracts were screened against our exclusion/inclusion criteria and 25 (3.6 %) studies met the quality assessments. A total of 18 studies were retrospective observational and 2 were prospective cohort studies. Elevated IL-10, up to day 7 of fever onset, stood out as a candidate prognostic marker for SD using the 1997 and 2009 World Health Organization (WHO) case definitions. IFNg was another potential prognostic marker of SD (1997 WHO case definition), but its levels varied between studies. Significant heterogeneity in methodologies and patient cohorts prevent ready application of IL-10 and IFNg as prognostic markers to other dengue populations. Our results suggest that the current non-randomized studies are delivering inconsistent messages and higher-quality studies, with consistent methodologies and validation in independent patient cohorts, are needed to delineate confounding variables. Major gaps identified were full accounting and transparency of sampling days, dengue virus type, infection status and age group.

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Section: Prognostication Marker Candidates: Who (2009) Sdsupporting

confidence: 68%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Prognostication Marker Candidates: Who (2009) Sdmentioning

confidence: 99%

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Markers of dengue severity: a systematic review of cytokines and chemokines

Lee

Leong

Wilder‐Smith

2016

Journal of General Virology

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Sequential MAVS and MyD88/TRIF signaling triggers anti‐viral responses of tick‐borne encephalitis virus‐infected murine astrocytes

Ghita

Breitkopf

Mulenge

et al. 2021

J of Neuroscience Research

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Definitions for warning signs and signs of severe dengue according to the WHO 2009 classification: Systematic review of literature

Morra

Altibi

Iqtadar

et al. 2018

Reviews in Medical Virology

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Since warning signs and signs of severe dengue are defined differently between studies, we conducted a systematic review on how researchers defined these signs. We conducted an electronic search in Scopus to identify relevant articles, using key words including dengue, "warning signs," "severe dengue," and "classification." A total of 491 articles were identified through this search strategy and were subsequently screened by 2 independent reviewers for definitions of any of the warning or severe signs in the 2009 WHO dengue classification. We included all original articles published in English after 2009, classifying dengue by the 2009 WHO classification or providing the additional definition or criterion of warning signs and severity (besides the information of 2009 WHO). Analysis of the extracted data from 44 articles showed wide variations among definitions and cutoff values used by physicians to classify patients diagnosed with dengue infection. The establishment of clear definitions for warning signs and severity is essential to prevent unnecessary hospitalization and harmonizing the interpretation and comparability of epidemiological studies dedicated to dengue infection.

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High plasma levels of soluble ST2 but not its ligand IL-33 is associated with severe forms of pediatric dengue

Cited by 35 publications

References 46 publications

Markers of dengue severity: a systematic review of cytokines and chemokines

Markers of dengue severity: a systematic review of cytokines and chemokines

Sequential MAVS and MyD88/TRIF signaling triggers anti‐viral responses of tick‐borne encephalitis virus‐infected murine astrocytes

Definitions for warning signs and signs of severe dengue according to the WHO 2009 classification: Systematic review of literature

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