High performance thin layer chromatographic analysis of hydrolyzed tinidazole solutions II. Hydrolysis kinetics of tinidazole

Biotransformations of drugs belonging to nitrogen heterocycles

“…Thus, at pH 11 and 80 °C, the rate constant of hydrolysis of Metronidazole is 150 times lower than that of Tinidazole. 73 Nevertheless, the polarograms obtained both in alkaline solutions of Metronidazole and in alka line solutions of Tinidazole after heating at 80 °C for 30 min confirm the degradation of both drugs. It should be noted that in the case of Metronidazole, no electrochemically active compounds were found in solution.…”

Simultaneous Determination of Clarithromycin, Tinidazole and Omeprazole in Helicure Tablets Using Reflectance Near-Infrared Spectroscopy with the Aid of Chemometry

“…These methods included titrimetry [3][4][5], spectrophotometry [6][7][8],spectrofluorimetry [9], electrochemical [10,11], polarography [12], high performance liquid chromatography (HPLC) with several detection techniques [13][14][15][16][17], thin layer chromatography (TLC) and high performance thin layer chromatography (HPTLC) [18][19][20].…”

In vivo and real time determination of ornidazole and tinidazole and pharmacokinetic study by capillary electrophoresis with microdialysis

“…E-mail address: zzj18@hotmail.com (Z. Zhang). [5,6], high performance liquid chromatography [7,8], and a UV spectrophotometric method [9,10]. However, nearly all of these methods reported could not monitor drug concentration in blood on-line, real time and in vivo.…”