High-performance microfluidic rectifier based on sudden expansion channel with embedded block structure

Tsai, Chien‐Hsiung; Lin, Che-Hsin; Fu, Lung-Ming; Chen, Hui‐Chun

doi:10.1063/1.4704504

Cited by 27 publications

(12 citation statements)

References 50 publications

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“…Tsai et al 31 proposed a high-performance microfluidic rectifier incorporating a sudden expansion channel in a microchannel. Here a block structure embedded in the expansion channel is used to induce two vortex structures at the end of the microchannel under reverse flow conditions.…”

Section: E Comparison With Other Hydrodynamic Mechanismsmentioning

confidence: 99%

Optimization of microfluidic microsphere-trap arrays

Sarder

et al. 2013

Biomicrofluidics

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Microarray devices are powerful for detecting and analyzing biological targets. However, the potential of these devices may not be fully realized due to the lack of optimization of their design and implementation. In this work, we consider a microsphere-trap array device by employing microfluidic techniques and a hydrodynamic trapping mechanism. We design a novel geometric structure of the trap array in the device, and develop a comprehensive and robust framework to optimize the values of the geometric parameters to maximize the microsphere arrays' packing density. We also simultaneously optimize multiple criteria, such as efficiently immobilizing a single microsphere in each trap, effectively eliminating fluidic errors such as channel clogging and multiple microspheres in a single trap, minimizing errors in subsequent imaging experiments, and easily recovering targets. We use finite element simulations to validate the trapping mechanism of the device, and to study the effects of the optimization geometric parameters. We further perform microsphere-trapping experiments using the optimized device and a device with randomly selected geometric parameters, which we denote as the un-optimized device. These experiments demonstrate easy control of the transportation and manipulation of the microspheres in the optimized device. They also show that the optimized device greatly outperforms the un-optimized device by increasing the packing density by a factor of two, improving the microsphere trapping efficiency from 58% to 99%, and reducing fluidic errors from 48% to a negligible level (less than 1%). The optimization framework lays the foundation for the future goal of developing a modular, reliable, efficient, and inexpensive lab-on-a-chip system.

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Section: E Comparison With Other Hydrodynamic Mechanismsmentioning

confidence: 99%

Optimization of microfluidic microsphere-trap arrays

Sarder

et al. 2013

Biomicrofluidics

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“…The velocity distribution and streamlines were obtained through the experiments and commercial software FLUENT. Tsai et al [13][14][15] focused on the formation of recirculation zones in a sudden expansion microchannel. They found that Reynolds number and aspect ratio are both influential factors for flow patterns in microchannels.…”

Section: Introductionmentioning

confidence: 99%

Lattice Boltzmann numerical simulation and experimental research of dynamic flow in an expansion-contraction microchannel

et al. 2013

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This paper applies the lattice Boltzmann method (LBM) to a 3D simulation of micro flows in an expansion-contraction microchannel. We investigate the flow field under various inlet flow rates and cavity structures, and then systematically study the flow features of the vortex and Dean flow in this channel. Vortex formation analysis demonstrates that there is no observable vortex generated when the inlet flow rate is low enough. As the inlet flow rate increases, a small vortex first appears near the inlet, and then this vortex region will keep expanding until it fully occupies the cavity. A smaller cavity width may result in a larger vortex but the vortex is less influenced by cavity length. The Dean flow features at the outlet become more apparent with increasing inlet flow rate and more recirculation regions can be observed in the cross-section under over high inlet flow rate. In order to support the simulation results, some experimental processes are conducted successfully. It validates that the applied model can accurately characterize the flow in the microchannel. Results of simulations and experiments in this paper provide insights into the design and operation of microfluidic systems for particle/cell manipulation.

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“…[20][21][22][23] Typically, these systems comprise several functional devices designed to carry out specific tasks such as sample pretreatment and injection, species mixing, polymerase chain reaction, and cell/particle separation and counting. [24][25][26][27][28][29][30][31][32][33][34] Compared to their large-scale counterparts, microfluidic devices have numerous advantages, including a reduced sample and reagent consumption, an enhanced efficiency, an improved sensitivity, a shorter processing time, a lower power consumption, a greater portability, and a lower fabrication and operating cost.…”

Section: Introductionmentioning

confidence: 99%

Convenient quantification of methanol concentration detection utilizing an integrated microfluidic chip

Wang

Yang

et al. 2012

Biomicrofluidics

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A rapid and simple technique is proposed for methanol concentration detection using a PMMA (Polymethyl-Methacrylate) microfluidic chip patterned using a commercially available CO 2 laser scriber. In the proposed device, methanol and methanol oxidase (MOX) are injected into a three-dimensional circular chamber and are mixed via a vortex stirring effect. The mixture is heated to prompt the formation of formaldehyde and is flowed into a rectangular chamber, to which fuchsin-sulphurous acid is then added. Finally, the microchip is transferred to a UV spectrophotometer for methanol detection purposes. The experimental results show that a correlation coefficient of R 2 ¼ 0.9940 is obtained when plotting the optical density against the methanol concentration for samples and an accuracy as high as 93.1% are compared with the determined by the high quality gas chromatography with concentrations in the range of 2 $ 100 ppm. The methanol concentrations of four commercial red wines are successfully detected using the developed device. Overall, the results show that the proposed device provides a rapid and accurate means of detecting the methanol concentration for a variety of applications in the alcoholic beverage inspection and control field. V C 2012 American Institute of Physics. [http://dx

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High-performance microfluidic rectifier based on sudden expansion channel with embedded block structure

Cited by 27 publications

References 50 publications

Optimization of microfluidic microsphere-trap arrays

Optimization of microfluidic microsphere-trap arrays

Lattice Boltzmann numerical simulation and experimental research of dynamic flow in an expansion-contraction microchannel

Convenient quantification of methanol concentration detection utilizing an integrated microfluidic chip

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