High‐Performance Liquid Chromatographic Assay for Imipramine, Desipramine, and Their 2‐Hydroxylated Metabolites

Sutfin, T A; Jusko, William J.

doi:10.1002/jps.2600680612

Cited by 64 publications

(11 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Plasma amitriptyline, nortriptyline, desipramine and their hydroxy metabolite concentrations were quantified with a modified liquid chromatographic method according to Sutfin & Jusko (1979 .s0…”

Section: Pharmacokineticsmentioning

confidence: 99%

Effects of antidepressants on skilled performance.

Linnoila¹,

Johnson²,

Dubyoski³

et al. 1984

Brit J Clinical Pharma

View full text Add to dashboard Cite

Section: Pharmacokineticsmentioning

confidence: 99%

Effects of antidepressants on skilled performance.

Linnoila¹,

Johnson²,

Dubyoski³

et al. 1984

Brit J Clinical Pharma

View full text Add to dashboard Cite

“…Therefore, its quantification is necessary in different biological samples and bulk formulations, as well as in different finished product dosages forms such as tablets, capsules, injections, etc. Several analytical methods have been reported as generic methods for most antidepressants or exclusively for the quantitative determination of desipramine hydrochloride (DH) and its metabolites in biological samples using capillary electrophoresis, Gas Chromatography, Liquid Chromatography, UV and mass spec detection [4][5][6][7][8][9][10][11][12][13][14][15]. All of these methods require time-consuming and costly sample pretreatment.…”

Section: Introductionmentioning

confidence: 99%

Drug selective poly(vinyl chloride)-based sensor of desipramine hydrochloride

Gupta¹,

Pal²,

Singh³

2010

Electrochimica Acta

View full text Add to dashboard Cite

show abstract

“…Plasma and urinary concentrations of DMI and 2-OH-DMI were determined by the high-performance liquid chromatographic assay of Sutfin & Jusko (1979), with the modifications described by Kitanaka et al (1982). Briefly, to 0.5 ml of plasma standard or test sample, internal standard solution (imipramine) and 0.2 ml carbonate buffer (pH 10.5) were added in polypropylene test tubes.…”

Section: Methodsmentioning

confidence: 99%

Desipramine pharmacokinetics in Chinese and Caucasian volunteers.

Mv¹,

Ea²,

Chang³

et al. 1984

Brit J Clinical Pharma

View full text Add to dashboard Cite

In order to better define the role of pharmacokinetic variation in reported cross‐ethnic differences in dosing patterns of some psychoactive drugs, single dose kinetics of the tricyclic antidepressant desipramine (DMI) were studied in 14 Chinese and 16 Caucasian healthy volunteers. DMI and 2‐OH‐DMI concentrations were assayed with h.p.l.c. in serial plasma and 24 h urine samples over 5 days following an oral 100 mg dose of DMI. Mean total clearance of DMI (CLDMI) from plasma was significantly (P less than 0.05) higher in the Caucasians (123 +/‐ 57 l/h) than in the Chinese (73.5 +/‐ 38.8 l/h). There was no significant difference in the apparent clearance of DMI by hydroxylation, fraction of dose metabolized to the hydroxy metabolite, DMI t1/2 or plasma protein binding between the two groups. Trimodal distribution of CLDMI was found, with 4/14 (29%) Chinese demonstrating slow CL (less than 33 l/h) and 4/16 (25%) Caucasians rapid CL (greater than 195 l/h). Correcting CL values for the greater mean weight of the Caucasians did not alter the pattern of distribution. CLDMI did not correlate with body weight. Although environmental factors cannot be ruled out, these results are consistent with genetically based differences in hepatic metabolism, probably affecting pathways in addition to hydroxylation, and suggest that 30% of Orientals would be at risk for toxicity from routine doses of tricyclics or similarly metabolized drugs.

show abstract

High‐Performance Liquid Chromatographic Assay for Imipramine, Desipramine, and Their 2‐Hydroxylated Metabolites

Cited by 64 publications

References 17 publications

Effects of antidepressants on skilled performance.

Effects of antidepressants on skilled performance.

Drug selective poly(vinyl chloride)-based sensor of desipramine hydrochloride

Desipramine pharmacokinetics in Chinese and Caucasian volunteers.

Contact Info

Product

Resources

About