High-performance interactive analysis of split aptamer and HIV-1 Tat on multiwall carbon nanotube-modified field-effect transistor

Fatin, M. F.; Ruslinda, A. Rahim; Gopinath, Subash C. B.; Arshad, M. K. Md

doi:10.1016/j.ijbiomac.2018.12.066

Cited by 22 publications

(18 citation statements)

References 64 publications

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“…FET are also commonly used to detect HIV [90,92,93]. Fatin et al [92] developed a novel FET based biosensor using MWCNT as a layer for the immobilization of RNA aptamer as a probe to detect HIV Tat protein. Tat antigen is a regulatory protein that increases the viral transcription efficiency of HIV double strand DNA (dsDNA), thus increasing the number of transcripts made.…”

Section: Human Immunodeficiency Virus Biosensorsmentioning

confidence: 99%

Electrochemical Biosensors for the Detection of SARS-CoV-2 and Other Viruses

2021

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The last few decades have been plagued by viral outbreaks that present some of the biggest challenges to public safety. The current coronavirus (COVID-19) disease pandemic has exponentiated these concerns. Increased research on diagnostic tools is currently being implemented in order to assist with rapid identification of the virus, as mass diagnosis and containment is the best way to prevent the outbreak of the virus. Accordingly, there is a growing urgency to establish a point-of-care device for the rapid detection of coronavirus to prevent subsequent spread. This device needs to be sensitive, selective, and exhibit rapid diagnostic capabilities. Electrochemical biosensors have demonstrated these traits and, hence, serve as promising candidates for the detection of viruses. This review summarizes the designs and features of electrochemical biosensors developed for some past and current pandemic or epidemic viruses, including influenza, HIV, Ebola, and Zika. Alongside the design, this review also discusses the detection principles, fabrication techniques, and applications of the biosensors. Finally, research and perspective of biosensors as potential detection tools for the rapid identification of SARS-CoV-2 is discussed.

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Section: Human Immunodeficiency Virus Biosensorsmentioning

confidence: 99%

Electrochemical Biosensors for the Detection of SARS-CoV-2 and Other Viruses

2021

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“…148,149 The use of aptamers has gained popularity in electrochemical sensing due to their high selectivity and ability to overcome the Debye length limitation by undergoing target-specific conformational changes that occur in close proximity to sensing surfaces. 16,150 These conformational changes allow the detection of analytes even in high ionic strength solutions (i.e., solutions with very small k D ), which is a critical challenge when using protein-based bio-recognition elements. Thus, integration of aptamers with optimized binding properties into EG-CNTFETs leads to highly sensitive and selective biosensors.…”

Section: B Bio-recognition Elementsmentioning

confidence: 99%

Electrolyte-gated carbon nanotube field-effect transistor-based biosensors: Principles and applications

Shkodra

Petrelli

Angeli

et al. 2021

Applied Physics Reviews

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Nowadays, there is a high demand for sensitive and selective real-time analytical methods suitable for a wide range of applications, from personalized telemedicine, drug discovery, food safety, and quality control, to defense, security, as well as environmental monitoring. Biosensors are analytical devices able to detect bio-chemical analytes (e.g., neurotransmitters, cancer biomarkers, bio-molecules, and ions), through the combination of a bio-recognition element and a bio-transduction device. The use of customized bio-recognition elements such as enzymes, antibodies, aptamers, and ion-selective membranes facilitates achieving high selectivity. Among the different bio-transduction devices currently available, electrolyte-gated field-effect transistors, in which the dielectric is represented by an ionic liquid buffer solution containing the targeted analyte, are gaining increasing attention. Indeed, these biotransduction devices are characterized by superior electronic properties and intrinsic signal amplification that allow the detection of a wide rangeofbiomolecules with high sensitivity (down to pM concentration). A promising semiconducting material for bio-transduction devices is represented by carbon nanotubes, due to their unique electrical properties, nanosize, bio-compatibility, and their simple low-cost processability. This work provides acomprehensive and critical review of electrolyte-gated carbon nanotube field-effect transistor-based biosensors. First, an introduction to these bio-sensing devices is given. Next, the device configurations and operating principles are presented, and the most used materials and processes are reviewed with a particular focus on carbon nanotubes as the active material. Subsequently, different functionalization strategies reported in the literature, based on enzymes, antibodies, aptamers, and ion-selective membranes, are analyzed critically. Finally, present issues and challenges faced in the area are investigated,theconclusions are drawn, and a perspective outlook over the field of bio-sensing technologies, in general, is provided.

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“…As the ion concentration changes, the transfer curve of the CNTFET changes. This sensor has a detection limit of 1 pM within a linear detection range from 1 pM to 10 nM and also shows superior responsiveness in less than one minute, the response time is shown in Figure 8 d. Fatin [ 94 ] demonstrates a MWCNT-based sensor for HIV-1 virus which utilized a split RNA aptamer as the detection probe. The sensor has a detection limit of 600 pM.…”

Section: Cntfet-based Biological Sensorsmentioning

confidence: 99%

Carbon Nanotube Field-Effect Transistor-Based Chemical and Biological Sensors

Yao

Zhang

Jin

et al. 2021

Sensors

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Chemical and biological sensors have attracted great interest due to their importance in applications of healthcare, food quality monitoring, environmental monitoring, etc. Carbon nanotube (CNT)-based field-effect transistors (FETs) are novel sensing device configurations and are very promising for their potential to drive many technological advancements in this field due to the extraordinary electrical properties of CNTs. This review focuses on the implementation of CNT-based FETs (CNTFETs) in chemical and biological sensors. It begins with the introduction of properties, and surface functionalization of CNTs for sensing. Then, configurations and sensing mechanisms for CNT FETs are introduced. Next, recent progresses of CNTFET-based chemical sensors, and biological sensors are summarized. Finally, we end the review with an overview about the current application status and the remaining challenges for the CNTFET-based chemical and biological sensors.

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High-performance interactive analysis of split aptamer and HIV-1 Tat on multiwall carbon nanotube-modified field-effect transistor

Cited by 22 publications

References 64 publications

Electrochemical Biosensors for the Detection of SARS-CoV-2 and Other Viruses

Electrochemical Biosensors for the Detection of SARS-CoV-2 and Other Viruses

Electrolyte-gated carbon nanotube field-effect transistor-based biosensors: Principles and applications

Carbon Nanotube Field-Effect Transistor-Based Chemical and Biological Sensors

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