High-performance compact SPR sensor for multi-analyte sensing

Vala, Milan; Chadt, Karel; Piliarik, Marek; Homola, Jiřı́

doi:10.1016/j.snb.2010.05.067

Cited by 65 publications

(32 citation statements)

References 13 publications

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“…Similar compact SPR sensors based on a gold-coated grating coupled system with a much greater number of channels have been developed. [7][8][9] The sensitivity resolutions of these SPR sensors were almost at the same level as the SPR sensor reported by Piliarik et al Dostálek et al reported a method to prepare an array of gratings for an SPR sensor chip with multi-sensing points. 10 In their reports, an interference pattern generated from two coherent lights was used to prepare a master grating; its pattern was replicated to an elastomer stamp.…”

Section: Introductionsupporting

confidence: 58%

“…In the case of (1), an SPR sensor chip with an Au layer, which was prepared by depositing Au on a substrate with a grating structure, was assembled into a flow cell having multi-channels, and the reflected light was monitored by a 2-dimension CCD or CMOS sensor. [6][7][8][9] For example, Piliarik et al 6 developed a compact SPR sensor based on a gold-coated grating having 4 channels, and reported that its sensitivity resolution was ca. 3 × 10 -7 RIU.…”

Section: Introductionmentioning

confidence: 99%

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Development of a Portable Surface Plasmon Resonance Sensor with Multi-Sensing Points Based on the Linear CCD Sensor

et al. 2016

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A portable-type surface plasmon resonance (SPR) sensor, composed from a new optical system for multi-sensing, has been developed to apply to environment analysis, clinical diagnosis etc., where many samples are desired to be analyzed at high throughput. The optical system of the sensor consists of a light-emitting diode, a pair of cylindrical lenses, a pair of collimator lenses, a correction lens, a prism, a polarizer and a linear CCD sensor with 2048 pixels. Reflected light from a sensor chip of the width of 6 mm at a certain incident angle was detected by ca. 618 pixels of the linear CCD sensor as an SPR sensor signal. An SPR sensor signal at a specified incident angle is controllable for optimization by adjusting the position of the CCD sensor. A sensor chip having a 30-stripe linear pattern (100 μm width/stripe) was prepared. The spatial resolution as well as the performance of the sensor were evaluated by using sucrose solutions. As a result, the acquisition of SPR sensor signals from 30 sensing points was successfully achieved with a spatial resolution of 100 μm (distance between 2 sensing points). A lower detection limit of ca. 3.2 -5.5 × 10 -5 RIU with a standard deviation of ±4.5% was obtained by averaging the signals from 6 -7 pixels of the CCD sensor per one sensing stripe.

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Section: Introductionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Development of a Portable Surface Plasmon Resonance Sensor with Multi-Sensing Points Based on the Linear CCD Sensor

et al. 2016

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“…Homola’s group has presented simple and compact prism-based SPR sensors with high performance. 87,88 However, performing transmission-mode spectroscopy (e.g. using nanohole arrays) in collinear setup offers some practical advantages, since it is more forgiving to a sample misalignment or tilt compared with the Kretschmann setup.…”

Section: Plasmon Spectroscopy For High-resolution Biosensingmentioning

confidence: 99%

Promises and challenges of nanoplasmonic devices for refractometric biosensing

et al. 2013

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Optical biosensors based on surface plasmon resonance (SPR) in metallic thin films are currently standard tools for measuring molecular binding kinetics and affinities – an important task for biophysical studies and pharmaceutical development. Motivated by recent progress in the design and fabrication of metallic nanostructures, such as nanoparticles or nanoholes of various shapes, researchers have been pursuing a new generation of biosensors harnessing tailored plasmonic effects in these engineered nanostructures. Nanoplasmonic devices, while demanding nanofabrication, offer tunability with respect to sensor dimension and physical properties, thereby enabling novel biological interfacing opportunities and extreme miniaturization. Here we provide an integrated overview of refractometric biosensing with nanoplasmonic devices and highlight some recent examples of nanoplasmonic sensors capable of unique functions that are difficult to accomplish with conventional SPR. For example, since the local field strength and spatial distribution can be readily tuned by varying the shape and arrangement of nanostructures, biomolecular interactions can be controlled to occur in regions of high field strength. This may improve signal-to-noise and also enable sensing a small number of molecules. Furthermore, the nanoscale plasmonic sensor elements may, in combination with nanofabrication and materials-selective surface-modifications, make it possible to merge affinity biosensing with nanofluidic liquid handling.

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“…The parallel and precise sample delivery capability in microfluidics enables the multiplexed detection . For example, Vala et al have demonstrated a compact SPR sensor that is capable of simultaneous detection of up to ten types of analytes based on angular interrogation of SPR on an Au‐coated diffraction grating contained in a disposable sensor cartridge with ten independent fluidic channels ( Figure ) . The sensor prototype has a detection limit of below 1 nM for short oligonucleotides.…”

Section: Microfluidics‐enhanced Plasmonic Devicesmentioning

confidence: 99%

Plasmofluidics: Merging Light and Fluids at the Micro-/Nanoscale

Wang

Zhao

Miao

et al. 2015

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Plasmofluidics is the synergistic integration of plasmonics and micro/nano fluidics in devices and applications in order to enhance performance. There has been significant progress in the emerging field of plasmofluidics in recent years. By utilizing the capability of plasmonics to manipulate light at the nanoscale, combined with the unique optical properties of fluids, and precise manipulation via micro/nano fluidics, plasmofluidic technologies enable innovations in lab-on-a-chip systems, reconfigurable photonic devices, optical sensing, imaging, and spectroscopy. In this review article, we examine and categorize the most recent advances in plasmofluidics into plasmon-enhanced functionalities in microfluidics and microfluidics-enhanced plasmonic devices. The former focuses on plasmonic manipulations of fluids, bubbles, particles, biological cells, and molecules at the micro-/nano-scale. The latter includes technological advances that apply microfluidic principles to enable reconfigurable plasmonic devices and performance-enhanced plasmonic sensors. We conclude with our perspectives on the upcoming challenges, opportunities, and the possible future directions of the emerging field of plasmofluidics.

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High-performance compact SPR sensor for multi-analyte sensing

Cited by 65 publications

References 13 publications

Development of a Portable Surface Plasmon Resonance Sensor with Multi-Sensing Points Based on the Linear CCD Sensor

Development of a Portable Surface Plasmon Resonance Sensor with Multi-Sensing Points Based on the Linear CCD Sensor

Promises and challenges of nanoplasmonic devices for refractometric biosensing

Plasmofluidics: Merging Light and Fluids at the Micro-/Nanoscale

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