High-performance antiviral nano-systems as a shield to inhibit viral infections: SARS-CoV-2 as a model case study

Sadique, Mohd Abubakar; Yadav, Shalu; Ranjan, Pushpesh; Verma, Sarika; Salammal, Shabi Thankaraj; Khan, Mohd. Akram; Kaushik, Ajeet; Khan, Raju

doi:10.1039/d1tb00472g

Cited by 61 publications

(55 citation statements)

References 81 publications

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“…The use of titanium dioxide (TiO 2 ) nanoparticle-based photocatalysts are able to neutralize the virus. The photocatalyst features of TiO 2 have been observed to perform better in antiviral/antimicrobial settings with a higher surface area (Sadique et al, 2021). As such, multiple methods of forming and using these devices have been documented.…”

Section: Efficient Trapping and Eradication Of Newer Severe Acute Respiratory Syndrome Coronavirus 2 Variantsmentioning

confidence: 99%

“…One of the most effective and simple solutions to reduce the spread of COVID-19 is face masks/shields that reduce the transmission of virus caused aerofluid dyanamix i.e., droplets, aerosols, airborne, and particulates containing SARS-CoV-2. Masks, however, vary significantly in design according to dimensions, materials (antiviral/antibacterial/oxidant or a combination of these), and effectiveness (capability of trapping and eradication) (Sadique et al, 2021). In this direction, the N95 masks have been demonstrated to be the most effective at reducing the spread of COVID-19, as they can reduce escaping particles (size 0.3 micron) by 95% and incoming particles by 70%.…”

Section: Efficient Trapping and Eradication Of Newer Severe Acute Respiratory Syndrome Coronavirus 2 Variantsmentioning

confidence: 99%

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Perspectives of Manipulative and High-Performance Nanosystems to Manage Consequences of Emerging New Severe Acute Respiratory Syndrome Coronavirus 2 Variants

Gage

Brunson

Morris

et al. 2021

Front. Nanotechnol.

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The emergence of new SARS-CoV-2 variants made the COVID-19 infection pandemic and/or endemic more severe and life-threatening due to ease of transmission, rapid infection, high mortality, and capacity to neutralize the therapeutic ability of developed vaccines. These consequences raise questions on established COVID-19 infection management strategies based on nano-assisted approaches, including rapid diagnostics, therapeutics, and efficient trapping and virus eradication through stimuli-assisted masks and filters composed of nanosystems. Considering these concerns as motivation, this perspective article highlights the role and aspects of nano-enabled approaches to manage the consequences of the COVID-19 infection pandemic associated with newer SARS-CoV-2 variants of concern and significance generated due to mutations. The controlled high-performance of a nanosystem seems capable of effectively detecting new variables for rapid diagnostics, performing site-specific delivery of a therapeutic agent needed for effective treatment, and developing technologies to purify the air and sanitizing premises. The outcomes of this report project manipulative, multifunctional nanosystems for developing high-performance technologies needed to manage consequences of newer SARS-CoV-2 variants efficiently and effectively through an overall targeted, smart approach.

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Section: Efficient Trapping and Eradication Of Newer Severe Acute Respiratory Syndrome Coronavirus 2 Variantsmentioning

confidence: 99%

Section: Efficient Trapping and Eradication Of Newer Severe Acute Respiratory Syndrome Coronavirus 2 Variantsmentioning

confidence: 99%

Perspectives of Manipulative and High-Performance Nanosystems to Manage Consequences of Emerging New Severe Acute Respiratory Syndrome Coronavirus 2 Variants

Gage

Brunson

Morris

et al. 2021

Front. Nanotechnol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Metallic, silica, polymeric or carbon-based nanomaterials (nanoparticles or nanotubes) functionalised with biomolecules such as DNA, RNA, peptides, aptamers, antibodies or antigens are used on a large scale for virus detection through colourimetric or antigen-binding assays [162][163][164][165] due to their optical, magnetic, electric or catalytic properties [166][167][168]. The main advantage of the nanomaterials is the high surface-tovolume ratio that can accelerate the sensor-analyte interaction for faster and effective detection of the virus [169].…”

Section: Nanotechnological Approachesmentioning

confidence: 99%

Point-of-Care Testing—The Key in the Battle against SARS-CoV-2 Pandemic

et al. 2021

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The deleterious effects of the coronavirus disease 2019 (COVID-19) pandemic urged the development of diagnostic tools to manage the spread of disease. Currently, the “gold standard” involves the use of quantitative real-time polymerase chain reaction (qRT-PCR) for SARS-CoV-2 detection. Even though it is sensitive, specific and applicable for large batches of samples, qRT-PCR is labour-intensive, time-consuming, requires trained personnel and is not available in remote settings. This review summarizes and compares the available strategies for COVID-19: serological testing, Point-of-Care Testing, nanotechnology-based approaches and biosensors. Last but not least, we address the advantages and limitations of these methods as well as perspectives in COVID-19 diagnostics. The effort is constantly focused on understanding the quickly changing landscape of available diagnostic testing of COVID-19 at the clinical levels and introducing reliable and rapid screening point of care testing. The last approach is key to aid the clinical decision-making process for infection control, enhancing an appropriate treatment strategy and prompt isolation of asymptomatic/mild cases. As a viable alternative, Point-of-Care Testing (POCT) is typically low-cost and user-friendly, hence harbouring tremendous potential for rapid COVID-19 diagnosis.

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“…In this direction, this opinion article explores nano-technology based alternate medicinal platforms, mediated through nanomaterials to address or mitigate such viral outbreaks. In this report, our focus is on the potential routes of NSs-assisted strategies such as antibacterial/viral coating and membranes, lipid encapsulated drug formulations of improved efficacy, immune capture assisted sensors amongst others to combat COVID-19 infection, and a way forward to assess the limitations of nanotechnology [ [17] , [18] , [19] ].…”

Section: Introduction: Emergence To Manage Cov-19 Pandemicmentioning

confidence: 99%

Antibacterial and antiviral high-performance nanosystems to mitigate new SARS-CoV-2 variants of concern

Tiwari

Juneja

Ghosal

et al. 2022

Current Opinion in Biomedical Engineering

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High-performance antiviral nano-systems as a shield to inhibit viral infections: SARS-CoV-2 as a model case study

Abstract: The recent COVID-19 pandemic is uncontrollable since the SARS-CoV-2 virus has a contagious transmission and causes fatal illness. Thus, it is vital to avoid this spread using high-performance antiviral nanomaterials to eradicate viral infections.

Cited by 61 publications

References 81 publications

Perspectives of Manipulative and High-Performance Nanosystems to Manage Consequences of Emerging New Severe Acute Respiratory Syndrome Coronavirus 2 Variants

Perspectives of Manipulative and High-Performance Nanosystems to Manage Consequences of Emerging New Severe Acute Respiratory Syndrome Coronavirus 2 Variants

Point-of-Care Testing—The Key in the Battle against SARS-CoV-2 Pandemic

Antibacterial and antiviral high-performance nanosystems to mitigate new SARS-CoV-2 variants of concern

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