Antibacterial and antiviral high-performance nanosystems to mitigate new SARS-CoV-2 variants of concern

Tiwari, Shivani; Juneja, Subhavna; Ghosal, Anujit; Bandara, Nandika; Khan, Raju; Wallen, Scott L.; Ramakrishna, Seeram

doi:10.1016/j.cobme.2021.100363

Cited by 47 publications

(39 citation statements)

References 51 publications

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“…In this direction, such engineered vaccines can be delivered at a target site using nanomedicine approaches. 23 , 25 , 26 , 27 Nanomedicine can also be engineered to manage Omicron along with postinfection consequences with the help of another therapeutic agent, and a nutraceutical can be a good choice in these circumstances. A nanomedicine formulated by an engineered vaccine (to tackle virus) and nutraceuticals (to support postinfection via supporting immune systems) can be optimized as precision medicine.…”

Section: Omicron‐sars‐cov‐2 Managementmentioning

confidence: 99%

SARS‐CoV‐2 Omicron variant: A next phase of the COVID‐19 pandemic and a call to arms for system sciences and precision medicine

Mostafavi

Dubey²,

Teodori

et al. 2022

MedComm

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Since early 2020, coronavirus diseases 2019 (COVID‐19) infection pandemic/endemic is constantly surprising health experts because of continuous variations in the structures of severe acute respiratory coronavirus 2 (SARS‐CoV‐2) in the form of newly emerged variants. Such mutations have exhibited high mortality and severity due to the newly emerged more infectious sites of SARS‐CoV‐2, making viral infection more transmissible, infectious, and severe. Recently, SARS‐CoV‐2 mutated to another variant, namely, Omicron (B.1.1.529), which is many times more transmissible and infectious than existed deadly Delta variants of the virus. This severity is closely correlated to a larger number of mutations observed in the receptor‐binding domain of the spike protein of the Omicron‐SARS‐CoV‐2. Considering severity, Omicron has been declared as variant of concerns by the World Health Organization and within days from its emergence, Omicron infection has spread globally, increased hospitalization, exhibited more severity for the young generation, invaded defense mechanism of natural immunity, not responsive to the available vaccines. Such circumstances resonated with the efficiency of available strategies established to manage COVID‐19 intelligently and successfully. To explore these aspects, this perspective article carefully and critically summarizes the Omicron's origin, structure, pathogenesis, impact health along with health systems, and experts’ recommendations to manage it successfully.

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Section: Omicron‐sars‐cov‐2 Managementmentioning

confidence: 99%

SARS‐CoV‐2 Omicron variant: A next phase of the COVID‐19 pandemic and a call to arms for system sciences and precision medicine

Mostafavi

Dubey²,

Teodori

et al. 2022

MedComm

Self Cite

View full text Add to dashboard Cite

show abstract

“…Regarding the aspects of personalized health wellness based on novel materials for diagnostic, treatment, and antibacterial performance [ 18 , [36] , [37] , [38] , [39] ], everyone should pay special attention to indoor air quality as we do for water and food quality. The health consequences in case of contaminated air are noticeably serious and now are well-explored.…”

Section: Conclusion and Viewpointmentioning

confidence: 99%

“…The coating of surfaces using antiviral or antibacterial materials (Cu, Ag, TiO 2 , etc.) is an excellent approach to prevent fomite transmission [18] .…”

Section: Introductionmentioning

confidence: 99%

“…The COVID-19 infection via aerosol is one of the critical and most widely investigated modes of transmission. These virus-containing aerosol droplets of respiratory fluids are smaller in size (< 5 µm) and can travel in the air up to 6 feet [ 17 , 18 ]. Aerosols are generated during expiratory events such as coughing and sneezing.…”

Section: Introductionmentioning

confidence: 99%

“…Under certain conditions, aerosols can travel up to 30 feet in distance. In addition, environmental temperature and humidity can enhance the viability of the aerosolized virus and make them survive for a longer duration of time [ 17 , 18 ]. A regular mask may not be sufficient to trap all the virus-containing aerosol.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Photoelectrochemical oxidation assisted air purifiers; perspective as potential tools to control indoor SARS-CoV-2 Exposure

Kaushik

Dhau²

2022

Applied Surface Science Advances

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Ginkgo biloba in the management of the COVID‐19 severity

Al-Kuraishy

Al-Gareeb

Kaushik

et al. 2022

Archiv der Pharmazie

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The severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection is linked with inflammatory disorders and the development of oxidative stress in extreme cases. Therefore, anti‐inflammatory and antioxidant drugs may alleviate these complications. Ginkgo biloba L. folium extract (EGb) is a herbal medicine containing various active constituents. This review aims to provide a critical discussion on the potential role of EGb in the management of coronavirus disease 2019 (COVID‐19). The antiviral effect of EGb is mediated by different mechanisms, including blocking SARS‐CoV‐2 3‐chymotrypsin‐like protease that provides trans‐variant effectiveness. Moreover, EGb impedes the development of pulmonary inflammatory disorders through the diminution of neutrophil elastase activity, the release of proinflammatory cytokines, platelet aggregation, and thrombosis. Thus, EGb can attenuate the acute lung injury and acute respiratory distress syndrome in COVID‐19. In conclusion, EGb offers the potential of being used as adjuvant antiviral and symptomatic therapy. Nanosystems enabling targeted delivery, personalization, and booster of effects provide the opportunity for the use of EGb in modern phytotherapy.

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Antibacterial and antiviral high-performance nanosystems to mitigate new SARS-CoV-2 variants of concern

Cited by 47 publications

References 51 publications

SARS‐CoV‐2 Omicron variant: A next phase of the COVID‐19 pandemic and a call to arms for system sciences and precision medicine

SARS‐CoV‐2 Omicron variant: A next phase of the COVID‐19 pandemic and a call to arms for system sciences and precision medicine

Photoelectrochemical oxidation assisted air purifiers; perspective as potential tools to control indoor SARS-CoV-2 Exposure

Ginkgo biloba in the management of the COVID‐19 severity

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