High overexpression of fatty acid synthase is associated with poor survival in Chinese patients with gastric carcinoma

Abstract

Fatty acid synthase (FAS) is the key enzyme regulating de novo biosynthesis of fatty acids. FAS overexpression has been found in many types of tumors and is associated with poor survival. However, the expression of FAS and its relationship with prognosis in Chinese patients with gastric carcinoma are still unknown. Therefore, in this study, we examined the expression of FAS using tissue microarrays and determined its correlation with clinicopathological characteristics and prognosis of gastric carcinoma in Chinese patients. FAS overexpression was graded as S (T/A) <1, ≥1 to <2, ≥2 to <3 or ≥3 in 35 (38.9%), 20 (22.2%), 9 (10%) and 26 (28.9%) patients, respectively. High FAS overexpression [S (T/A) ≥3] was significantly correlated with poor prognosis (log-rank test, P= 0.0078) and with decreased 3-year survival rate (χ2 test, P=0.0023). FAS overexpression was not significantly associated with other clinicopathological characteristics. In conclusion, our results suggest that FAS expression might be a potential prognostic marker for gastric carcinoma in Chinese patients.

Small interfering RNA‑mediated knockdown of fatty acid synthase attenuates the proliferation and metastasis of human gastric cancer cells via the mTOR/Gli1 signaling pathway

“…The present study demonstrated that the expression of FASN in GC tissues was increased compared with that in adjacent normal tissues, as indicated by other previous studies (15,16). To the best of our knowledge, the present study also provided the first evidence that the knockdown of FASN via siRNA inhibited the proliferation and migration of GC cells.…”

“…FASN is overexpressed in human GC. Previous studies (15)(16)(17) have provided evidence that FASN is overexpressed in GC tissues and that its overexpression is closely associated with GC metastasis and patient survival. To further investigate the potential role of FASN in the development of GC, western blotting was used in the present study to examine FASN expression in human GC tissues and paired adjacent normal tissues.…”

“…However, studies focusing upon FASN in GC are limited. Previous studies (15)(16)(17) have provided evidence that FASN is overexpressed in GC tissues, and that its overexpression is closely associated with GC metastasis and survival, indicating that FASN contributes to the development and progression of GC. However, the functional role of FASN expression in GC cells remains unclear, and the concrete molecular mechanisms of the regulation of cell proliferation and metastasis by FASN are not well understood.…”

“…Fatty acid synthase (FASN), the main enzyme involved in de novo lipogenesis, is overexpressed in several types of tumor tissues including breast cancer, colorectal cancer and gastric cancer, and its overexpression is significantly associated with tumor cell proliferation, metastasis, epithelial-mesenchymal transition (EMT) and a poor prognosis (12)(13)(14)(15). However, there are only a few studies focusing on FASN in GC (15)(16)(17), and these indicate that FASN is overexpressed in the GC tissues and blood serum of patients with GC, and that its overexpression is connected with poor survival rate. These data suggest that FASN serves a critical role in the development and progression of GC, but the precise functions and internal mechanisms of FASN in GC cell proliferation and metastasis remain elusive.…”

Ferns and Lycopods—A Potential Treasury of Anticancer Agents but Also a Carcinogenic Hazard

“…Another promising effect of amentoflavone is that it inhibits fatty acid synthase (FAS) (Lee et al ., ), an enzyme which is overexpressed in solid tumours and associated with their poor prognosis (Hou et al ., ). Lee et al .…”