High osteoporotic fracture risk and CVD risk co-exist in postmenopausal women

Abstract

32 Results: Women with higher 10 year risk of major osteoporotic had significantly higher cardiovascular risk 33 (4.634% vs 8.36%, p =0.001). In multiple regression analysis, 5-year CVD risk was significantly associated with 34 the 10-year risk of having major osteoporotic (β=0.095, p=0.001) and hip (β =0.055, p=0.001) fracture.35 Women with the highest CVD risk were 5.4 times more likely to have higher risk of major osteoporotic fracture. 36 Conclusions: Fracture risk, determined by using a multiple risk factor algorithm such as FRAX, was positively 37 associated with higher cardiovascular risk determined by using the Framingham Risk Tool. Awareness regarding 38 these concurrent risk factors needs to be raised so that appropriate risk reduction can be implemented. 51Although BMD has shown a strong association with fracture risk, 52 most fractures occur in subjects with T-scores above −2.5, the 53 threshold typically used to define osteoporosis, which means that 54 relying solely on BMD will miss many patients at risk of fracture. Clin-55 ical risk factors are also associated with an increased probability of 64In the present study, we investigated the relationship between 65 bone and cardiovascular pathways by calculating fracture risk using 66 the FRAX [15][16][17][18] tool and comparing it to cardiovascular risk assessed 67 by the Framingham Heart Risk tool [9,10] in a large population of peri 68 and postmenopausal women. 69 Methods 70 Subjects 71Study subjects were female twins over 45 years, recruited as part of 72

Correlations between 10-year risk of death from cardiovascular diseases

“…What is more, the 10-year risk of fatal CVD risk, observed in that group of patients, significantly correlated with the 10-year risk of major fractures and hip fractures. We also found similar results in the literature: women with the highest risk of CVD have a higher risk of major osteoporotic fractures [10], which may be associated with the pathophysiological disorders common in both processes. A common pathogenesis of the two medical conditions may, for example, indicate mutual correlations of medicinal agents, exerted on particular disease entities.…”

“…It is an important fact that both osteoporosis and cardiovascular disorders are associated with a significant risk of disability and mortality, while only a few studies have attempted to analyse both diseases as related conditions [9][10][11][12].…”

Increasing Risk of Osteoporotic Fracture Is Associated With Vascular Dysfunction and Abnormal Vascular Structure in Both Men and Women

“…28 Makovey et al reported that risk of osteoporotic fracture was significantly correlated with Framingham risk score. 17 In the present study, vascular function assessed on FMD and NID and vascular structure assessed using brachial artery IMT were impaired as FRAX risk of osteoporotic fracture increased. This suggests that risk of osteoporotic fracture is associated with vascular function and vascular structure.…”

“…6, 10 Clinical and epidemiological studies have shown a link between osteoporosis and cardiovascular disease. [15][16][17] Although osteoporosis and cardiovascular disease share many common risk factors, growing evidence also indicates that there are common pathophysiological mechanisms underlying these diseases. 18 Both vascular calcification and bone mineralization are regulated by several shared boneassociated proteins, such as osteocalcin, osteopontin, bone morphogenetic proteins (BMP), and osteoprotegerin.…”

Associations of absolute risk of osteoporotic fractures (FRAX®) and total cardiovascular risk (SCORE) in urban population of the Russian Federation

“…Полученные результаты были сходны с единичными исследованиями в этой области. Работа по изучению взаимосвязи ССР и риска ОПП была проведена австралийскими учеными с применением Фремингемской шкалы для оценки риска ССЗ и австралийской модели FRAX ® без включения МПК для оценки риска ОПП у 358 женщин в возрасте 45-74 лет [26]. Авторы продемонстрировали, что женщины с высоким 10-летним риском основных ОПП имели более высокий ССР 4,63% vs 8,36%, (р=0,001).…”