High novelty-seeking predicts greater sensitivity to the conditioned rewarding effects of cocaine

Vidal-Infer, Antonio; Arenas, M. Carmen; Daza-Losada, Manuel; Aguilar, M.A.; Miñarro, José; Rodrı́guez-Arias, Marta

doi:10.1016/j.pbb.2012.03.031

Cited by 57 publications

(39 citation statements)

References 71 publications

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“…Individual differences in behaviour have been identified in many vertebrate species [24 – 26] including humans [27]. Activity levels of zebrafish have been investigated in the past and have often been found to exhibit a high degree of variance.…”

Section: Discussionmentioning

confidence: 99%

Individual differences in activity levels in zebrafish (Danio rerio)

Tran

2013

Behavioural Brain Research

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Individual differences and variation in behavioural responses have been identified in many animal species. These differences may be the result of genetic or environmental factors or the interaction between them. Analysis of individual differences in behaviour may be important for many reasons. The zebrafish is a powerful model organism that is rapidly gaining popularity in behavioural brain research. However, individual differences have rarely been explored in zebrafish although significant variation in their performance has been reported. In the current study we identified individual differences in activity levels of zebrafish using a genetically heterogeneous population. Groups of zebrafish classified as high, medium, or low activity performers demonstrated consistent activity levels over a period of 7 days, and also in a subsequent open field task, suggesting stable individual differences as opposed to stochastic variation among subjects. We also uncovered a sex dependent relationship between behavioural measures. Female zebrafish in the high activity group preferred the top portion of the tank, whereas low activity females preferred the lower portion but males did not show such a relationship. The relationship between these two behaviours in females implies the potential existence of a behavioural syndrome persisting between contexts. Furthermore, females demonstrated a higher level of consistency in their behaviour as compared to males, and the behavioural differences were found to be independent of both body size and weight of the tested subjects. The identification of individual differences in activity levels in zebrafish will allow the investigation of underlying genetic and/or environmental underpinnings.

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Section: Discussionmentioning

confidence: 99%

Individual differences in activity levels in zebrafish (Danio rerio)

Tran

2013

Behavioural Brain Research

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“…However, these procognitive effects during initial cocaine exposure may be responsible for the formation of maladaptive drug-context/-cue associations that may facilitate the development of compulsive drug-seeking behavior. In support of this hypothesis, studies have shown that laboratory rodents learn to self-administer cocaine (e.g., Richardson and Roberts 1996;España et al 2010) and associate a specific context with cocaine reward (e.g., Spyraki et al 1982;Vidal-Infer et al 2012) remarkably quickly. The rewarding effects of cocaine are so powerful that a number of studies have shown that an especially addiction-prone subset of laboratory animals trained to selfadminister cocaine prefer cocaine over feeding and mating and compulsively self-administer cocaine at fatal rates (Deneau et al 1969;Lenoir et al 2007;Kerstetter et al 2012;Perry et al 2013).…”

Section: Cocainementioning

confidence: 97%

Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction

2016

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It has long been hypothesized that conditioning mechanisms play major roles in addiction. Specifically, the associations between rewarding properties of drugs of abuse and the drug context can contribute to future use and facilitate the transition from initial drug use into drug dependency. On the other hand, the self-medication hypothesis of drug abuse suggests that negative consequences of drug withdrawal result in relapse to drug use as an attempt to alleviate the negative symptoms. In this review, we explored these hypotheses and the involvement of the hippocampus in the development and maintenance of addiction to widely abused drugs such as cocaine, amphetamine, nicotine, alcohol, opiates, and cannabis. Studies suggest that initial exposure to stimulants (i.e., cocaine, nicotine, and amphetamine) and alcohol may enhance hippocampal function and, therefore, the formation of augmented drug-context associations that contribute to the development of addiction. In line with the self-medication hypothesis, withdrawal from stimulants, ethanol, and cannabis results in hippocampus-dependent learning and memory deficits, which suggest that an attempt to alleviate these deficits may contribute to relapse to drug use and maintenance of addiction. Interestingly, opiate withdrawal leads to enhancement of hippocampus-dependent learning and memory. Given that a conditioned aversion to drug context develops during opiate withdrawal, the cognitive enhancement in this case may result in the formation of an augmented association between withdrawalinduced aversion and withdrawal context. Therefore, individuals with opiate addiction may return to opiate use to avoid aversive symptoms triggered by the withdrawal context. Overall, the systematic examination of the role of the hippocampus in drug addiction may help to formulate a better understanding of addiction and underlying neural substrates.Addiction is a major worldwide health problem that results in maladaptive behavioral changes, some that can last a lifetime. This behavioral plasticity, often times maladaptive, must be associated changes in neural plasticity. In fact, it has been noted multiple times that there is a high degree of overlap between the neurobiology of learning and memory and the neurobiology of addiction

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“…Control groups were injected with physiological saline (NaCl 0.9%), which was also used to dissolve the drugs. The doses of cocaine were selected on the basis of previous studies showing that 1 mg/kg is a threshold dose (Vidal-Infer et al, 2012;Arenas et al, 2014;Montagud-Romero et al, 2014) and that 25 mg/kg induces a strong CPP that is reinstated after priming with 12.5 mg/kg of cocaine ).…”

Section: Drugsmentioning

confidence: 99%