High normal albuminuria is independently associated with aortic stiffness in patients with Type 2 diabetes

Abstract

High normal albuminuria is associated with aortic stiffness in patients with Type 2 diabetes, which may in part explain their increased cardiovascular risk.

High normal albuminuria is associated with arterial stiffness and carotid atherosclerosis in Korean patients with type 2 diabetes

“…In terms of arterial stiffness, previous studies reported positive associations of low-grade albuminuria with baPWV and carotid-femoral PWV in normoalbuminuric patients with T2DM [11,12]. In the present study, the strength of the association between ACR and baPWV was attenuated after adjustment for SBP and DBP both in multivariate logistic and regression models, suggesting that the effect was largely mediated by hemodynamic mechanisms.…”

“…Population-based studies showed that mortality rate increases with increasing urine albumin-to-creatinine ratio (ACR), and this relation starts before ACR reaches the levels considered as microalbuminuria [5]. Several studies found a significant association between high normal albuminuria and increased carotid intima-media thickness (IMT) [6e10] and arterial stiffness [11,12], both of which are surrogate markers of changes in vascular morphology and function. These findings highlight the possibility that lowgrade albuminuria may play a role in the pathogenesis of atherosclerosis.…”

Disability of Hearing Impairment Is Positively Associated With Urine Albumin/Creatinine Ratio in Korean Adults: The 2011–2012 Korea National Health and Nutrition Examination Survey

“…Even though A1 is defined as normal ACR, this study classified category A1 into four subgroups of ≥20 and <30 mg/g, ≥10 and <20 mg/g, ≥5 and <10 mg/g, and <5 mg/g. This is because many reports demonstrated that high ACR within the normal range is associated with other diseases [22-24]. …”

Ethnic disparity in central arterial stiffness and its determinants among Asians with type 2 diabetes

“…The Singapore Study of Macro-angiopathy and Micro-vascular Reactivity in Type 2 Diabetes (SMART2D) is a cross-sectional study conducted between August 2011 and February 2014 including a total of 2057 adults aged 21e90 years with T2DM [21]. The participants were recruited consecutively from a secondary hospital and a neighboring primary-care public outpatient clinic in equal proportion in Singapore.…”